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20 breakthroughs of 2025
Masoud Akbarzadeh holding up one of the fabricated materials.

The Polyhedral Structures Laboratory is housed at the Pennovation Center and brings together designers, engineers, and computer scientists to reimagine the built world. Using graphic statics, a method where forces are mapped as lines, they design forms that balance compression and tension. These result in structures that use far fewer materials while remaining strong and efficient.

(Image: Eric Sucar)

20 breakthroughs of 2025

From ancient tombs and tiny robots to personalized gene editing and AI weather models, Penn’s 2025 research portfolio showed how curiosity—paired with collaboration—moves knowledge into impact and stretches across disciplines and continents.

5 min. read

How one molecule keeps plants youthful
flowering acacia plant.

Image: Courtesy of Omnia.

How one molecule keeps plants youthful

In a career-defining paper, Scott Poethig, a biologist at the School of Arts & Sciences, has discovered that a single molecular switch can freeze plants in their juvenile state.

Marilyn Perkins

2 min. read

Evolution at a molecular level

Biologist Mia Levine and colleagues have demonstrated how a pair of essential protein partners undergo rapid evolutionary change to counter fast-evolving parasitic DNA while maintaining core cellular functions. The work presents novel insight into how evolution works at the molecular level.

(Image: Getty images/Joao Paulo Burini)

Evolution at a molecular level

Research led by Mia Levine shows how a vital DNA protection protein complex adapts to new threats without compromising essential functions.

3 min. read

Four from Penn receive Kaufman Foundation grants

Four from Penn receive Kaufman Foundation grants

Penn researchers will receive two of four grants awarded this year by the Charles E. Kaufman Foundation in support of interdisciplinary collaboration aimed at developing novel approaches to fundamental scientific questions.

2 min. read

A serendipitous find leads to lifesaving discoveries
Fluorescent imaging of glioblastoma under a microscope.

Image: Kyosuke Shishikura

A serendipitous find leads to lifesaving discoveries

A Penn-led team has revealed a how hydralazine, one of the world’s oldest blood pressure drugs and a mainstay treatment for preeclampsia, works at the molecular level. In doing so, they made a surprising discovery—it can also halt the growth of aggressive brain tumors.

3 min. read

Can tiny ocean organisms offer the key to better climate modeling?
Researcher Xin Sun injects substance into glass vials.

Xin Sun prepares samples collected from the Eastern Tropical North Pacific aboard a research vessel. By adding stable isotope tracers to these vials, Sun and her team can track how different microbial groups convert nitrogen compounds into nitrous oxide, revealing how subtle shifts in oxygen and organic matter change the ocean’s chemistry.

 
 

(Image: Courtesy of Xin Sun)

Can tiny ocean organisms offer the key to better climate modeling?

In the shadowy layers of the Pacific, microbes decide how much nitrous oxide—a potent greenhouse gas—rises skyward. New research from Penn’s Xin Sun offers an improved understanding of microbial ecology and geochemistry—key to forecasting global emissions in response to natural and man-made climate change.

3 min. read

Does early-life cellular activity influence cancer and aging?
Artist rendering of chromosome structure with telomeres highlighted at the ends.

Mia Levine and Michael Lampson’s research examines how telomere length is inherited, and how this can inform future genetic research in how cancer develops.

(Image: Courtesy of Getty/nopparit)

Does early-life cellular activity influence cancer and aging?

New research from Michael Lampson and Mia T. Levine in the School of Arts & Sciences offers insight into how telomeres—protective chromosomal caps linked to aging and cancer in mammals—are inherited. Their finding that telomeres become longer or shorter during early embryonic development opens new avenues for research.

3 min. read

A summer in the tick trenches
A person in PPE holding blue painters tape covered in several ticks.

nocred

A summer in the tick trenches

With the help of five Penn undergrads, biology professor Dustin Brisson’s research group collected 9,000 tick specimens this summer to understand how seasonal activity patterns of these arachnids affects human pathogens and what role a changing climate might play.

Kristina Linnea García

2 min. read