Cancer Research | Penn Today

Why CAR T cell therapy is the cancer killer the world needs now

Research from Michael Mitchell of the School of Engineering and Applied Science has developed a new method to stop cytokine release during CAR T cell therapy, preventing some of its more dangerous side effects.

Stroma-targeting CAR T cells (green) in the stroma surrounding a solid tumor.

Removing the barrier surrounding solid tumors clears path for T cells

Penn researchers uncover a new way to target solid tumors. Using CAR T cells to remove cancer-associated fibroblasts surrounding pancreatic tumors allows T cells to infiltrate and attack the tumor cells.

Penn’s cell therapy pioneer Dr. Carl June shares $3M Breakthrough Prize in Life Sciences

Carl June of the Perelman School of Medicine has been awarded a $3 million Breakthrough Prize in life sciences for developing CAR-T therapy to treat cancer, with remarks from President Liz Magill.

Penn’s Carl June splits a $3 million Breakthrough Prize for pioneering the cancer treatment CAR-T

Carl June of the Perelman School of Medicine has been honored with the $3 million Breakthrough Prize for discovering how to attack cancer by harnessing a patient’s immune system through CAR-T therapy.

Cancer treatment has come far, fast: Better prevention, early detection, new treatment

Carl June of the Perelman School of Medicine was awarded a $3 million Breakthrough Prize in life sciences for developing CAR-T therapy to treat cancer.

Fluorescent microscopy of colon cancer cells..

Genetic switch turns tumor suppressor into oncogene in colorectal cancer

Researchers from the School of Veterinary Medicine have shown that an enzyme that suppresses early-stage colorectal cancer switches to become an oncogene as the cancer progresses.

Microscopic rendering of a white blood cell amongst red blood cells.

An immunotherapy strategy against all blood cancers

Researchers at Penn Medicine have demonstrated a new potential treatment using CAR T cell therapy using a CRISPR base-editing to develop a method called “epitope editing.”

Carl June with a microphone in the Penn Medicine atrium with the celebratory flash mob.

Carl June on the boundless potential of CAR T cell therapy

In a Q & A, June, the Richard W. Vague Professor in Immunotherapy, and Daniel Baker, a fourth-year doctoral student in Penn’s Cell and Molecular Biology department, discuss how the treatment can extend to treating diseases beyond cancer.

After years of research, Pitt professor poised to test breast cancer vaccine

A Penn study testing a breast cancer vaccine in those who carry the breast cancer gene has vaccinated its first patient.

Philly gene therapy companies tap into city’s workforce training program for lab techs

Penn Medicine is noted for spearheading gene therapy for cancer treatment, being the first in the nation to use a gene editing tool to combat cancer in 2019.

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