Novel gene therapy platform speeds search for ways to cure blindness Novel gene therapy platform speeds search for ways to cure blindness A newly developed single-cell RNA sequencing technique enables researchers to quickly identify an optimal vector for delivering therapeutic genetic material to treat vision disorders, and perhaps other genetic conditions.
Four success stories in gene therapy Penn In the News Scientific American Four success stories in gene therapy Jean Bennett and Albert Maguire of the Perelman School of Medicine developed a gene therapy to treat blindness in patients with retinal dystrophy caused by mutations in the RPE65 gene. “These people can now do things they never could have dreamed of doing, and they’re more independent and enjoying life,” said Bennett. National Academy of Medicine welcomes two new members from Penn Marylyn D. Ritchie and Sarah A. Tishkoff are Penn’s newest elected members of the National Academy of Medicine. National Academy of Medicine welcomes two new members from Penn The Perelman School of Medicine’s Marylyn D. Ritchie and PIK Professor Sarah A. Tishkoff are among 100 new members to be elected this year to the Academy, one of the highest honors in health and medicine. A two-pronged approach to keep rheumatoid arthritis in check Painful inflammation characterizes rheumatoid arthritis, but a new study points to a possibly strategy to alleviate it: boosting levels of the protein DEL-1. A two-pronged approach to keep rheumatoid arthritis in check A new study led by George Hajishengallis of the School of Dental Medicine shows that the protein DEL-1 could reduce the painful inflammation of RA in an animal model. Imaging technology maps cells tied to inflammatory bowel disease Multicolor image of a colon from a patient with ulcerative colitis stained by imaging mass cytometry. (Image: Courtesy of Ayano Kondo from the Kaestner Lab) Imaging technology maps cells tied to inflammatory bowel disease “Imaging mass cytometry” shows how cells tied to inflammatory bowel disease affect intestinal tissue, generating new theories for the progression of Crohn’s disease and ulcerative colitis. Test predicts which patients with rare blood disease will respond to treatment David Fajgenbaum is an assistant professor of medicine at the Perelman School of Medicine at the University of Pennsylvania and associate director of patient impact in the Penn Orphan Disease Center. He also leads the Castleman Disease Research Program.(Image: Courtesy of Penn Medicine) Test predicts which patients with rare blood disease will respond to treatment A Penn Medicine study identifies blood proteins that indicate which patients with idiopathic multicentric Castleman disease are most likely to benefit from the only FDA approved treatment for the disease, and uncovers an alternative. Signaling dynamics fine-tune gene expressiong Penn In the News The Scientist Signaling dynamics fine-tune gene expressiong Lukasz Bugaj of the School of Engineering & Applied Science comments on a systematic and quantitative look at how gene information is transmitted and what can influence the amount of expression. The census has revealed a more multiracial U.S. One reason? Cheaper DNA tests Penn In the News WHYY (Philadelphia) The census has revealed a more multiracial U.S. One reason? Cheaper DNA tests Wendy Roth of the School of Arts & Sciences comments on the potential implications of genetic ancestry test results shaping how some people report their race for the census. Penn researchers unlock genetic ‘treasure map’ for chronic kidney disease Penn researchers unlock genetic ‘treasure map’ for chronic kidney disease The genome-wide association study pinpoints new target genes, cell types, and mechanisms for treating the disease that affects 850 people million worldwide. Protein’s ‘silent code’ affects how cells move Protein’s ‘silent code’ affects how cells move A School of Veterinary Medicine-led study shows how, despite having nearly identical amino acid sequences, two forms of the protein actin differ in function due their distinct nucleotide sequences. Load More
National Academy of Medicine welcomes two new members from Penn Marylyn D. Ritchie and Sarah A. Tishkoff are Penn’s newest elected members of the National Academy of Medicine. National Academy of Medicine welcomes two new members from Penn The Perelman School of Medicine’s Marylyn D. Ritchie and PIK Professor Sarah A. Tishkoff are among 100 new members to be elected this year to the Academy, one of the highest honors in health and medicine.
A two-pronged approach to keep rheumatoid arthritis in check Painful inflammation characterizes rheumatoid arthritis, but a new study points to a possibly strategy to alleviate it: boosting levels of the protein DEL-1. A two-pronged approach to keep rheumatoid arthritis in check A new study led by George Hajishengallis of the School of Dental Medicine shows that the protein DEL-1 could reduce the painful inflammation of RA in an animal model.
Imaging technology maps cells tied to inflammatory bowel disease Multicolor image of a colon from a patient with ulcerative colitis stained by imaging mass cytometry. (Image: Courtesy of Ayano Kondo from the Kaestner Lab) Imaging technology maps cells tied to inflammatory bowel disease “Imaging mass cytometry” shows how cells tied to inflammatory bowel disease affect intestinal tissue, generating new theories for the progression of Crohn’s disease and ulcerative colitis.
Test predicts which patients with rare blood disease will respond to treatment David Fajgenbaum is an assistant professor of medicine at the Perelman School of Medicine at the University of Pennsylvania and associate director of patient impact in the Penn Orphan Disease Center. He also leads the Castleman Disease Research Program.(Image: Courtesy of Penn Medicine) Test predicts which patients with rare blood disease will respond to treatment A Penn Medicine study identifies blood proteins that indicate which patients with idiopathic multicentric Castleman disease are most likely to benefit from the only FDA approved treatment for the disease, and uncovers an alternative.
Signaling dynamics fine-tune gene expressiong Penn In the News The Scientist Signaling dynamics fine-tune gene expressiong Lukasz Bugaj of the School of Engineering & Applied Science comments on a systematic and quantitative look at how gene information is transmitted and what can influence the amount of expression. The census has revealed a more multiracial U.S. One reason? Cheaper DNA tests Penn In the News WHYY (Philadelphia) The census has revealed a more multiracial U.S. One reason? Cheaper DNA tests Wendy Roth of the School of Arts & Sciences comments on the potential implications of genetic ancestry test results shaping how some people report their race for the census. Penn researchers unlock genetic ‘treasure map’ for chronic kidney disease Penn researchers unlock genetic ‘treasure map’ for chronic kidney disease The genome-wide association study pinpoints new target genes, cell types, and mechanisms for treating the disease that affects 850 people million worldwide. Protein’s ‘silent code’ affects how cells move Protein’s ‘silent code’ affects how cells move A School of Veterinary Medicine-led study shows how, despite having nearly identical amino acid sequences, two forms of the protein actin differ in function due their distinct nucleotide sequences. Load More
The census has revealed a more multiracial U.S. One reason? Cheaper DNA tests Penn In the News WHYY (Philadelphia) The census has revealed a more multiracial U.S. One reason? Cheaper DNA tests Wendy Roth of the School of Arts & Sciences comments on the potential implications of genetic ancestry test results shaping how some people report their race for the census. Penn researchers unlock genetic ‘treasure map’ for chronic kidney disease Penn researchers unlock genetic ‘treasure map’ for chronic kidney disease The genome-wide association study pinpoints new target genes, cell types, and mechanisms for treating the disease that affects 850 people million worldwide. Protein’s ‘silent code’ affects how cells move Protein’s ‘silent code’ affects how cells move A School of Veterinary Medicine-led study shows how, despite having nearly identical amino acid sequences, two forms of the protein actin differ in function due their distinct nucleotide sequences.
Penn researchers unlock genetic ‘treasure map’ for chronic kidney disease Penn researchers unlock genetic ‘treasure map’ for chronic kidney disease The genome-wide association study pinpoints new target genes, cell types, and mechanisms for treating the disease that affects 850 people million worldwide.
Protein’s ‘silent code’ affects how cells move Protein’s ‘silent code’ affects how cells move A School of Veterinary Medicine-led study shows how, despite having nearly identical amino acid sequences, two forms of the protein actin differ in function due their distinct nucleotide sequences.