Genes play a role in dog breed differences in behavior
Border collies are highly trainable, greyhounds love to chase, and German shepherds make good guard dogs. While the environment plays a role, traits like these are highly heritable. A new study identifies 131 genetic variants associated with breed differences in behavior.
Fruit flies’ microbiomes shape their evolution
In just five generations, an altered microbiome can lead to genome-wide evolution in fruit flies, according to new research led by Paul Schmidt and postdoc Seth Rudman of the School of Arts and Sciences.
Is treatment forever? Success of gene therapy for inherited blindness depends on timing
An FDA-approved gene therapy for Leber congenital amaurosis, an inherited vision disorder with a childhood onset and progressive nature, has improved patients’ sight. But new research underscores the importance of further investigation to halt the progression of the disorder.
A molecular ‘atlas’ of animal development
Scientists have studied the nematode worm Caenorhabditis elegans for decades, making essential contributions to basic science. In the latest milestone, a team uses cutting-edge technology to individually profile the genes expressed in more than 80,000 cells in a developing C. elegans embryo.
Cardiac genetic mutation may not always predict heart disease
Researchers at Penn Medicine and Geisinger find only 5% of patients with a mutation of the TTN gene have dilated cardiomyopathy, despite changes in heart function.
Finding clues to a genetic link to treatment for BRCA1/2 breast cancer patients
New research could shape treatment strategies and clinical trial design for patients with BRCA1 and BRCA2-related breast cancers.
New spinal muscle atrophy treatment gains approval
Zolgensma is based on a delivery system discovered by a Penn gene therapy pioneer, marking a new milestone in treating the rare disease.
Researchers use gene editing with CRISPR to treat lethal lung diseases before birth
Using CRISPR gene editing, a team from Penn Medicine and Children’s Hospital of Philadelphia have thwarted a lethal lung disease, in which a harmful mutation causes death within hours after birth.
Three from Penn elected to the American Academy of Arts and Sciences
Vice Provost for Faculty Anita Allen of the Law School and the School of Arts and Sciences, Daniel Rader of the Perelman School of Medicine, and Zeid Ra’ad Al Hussein of Perry World House join a group recognized for their world-class leadership and expertise.
Study reveals overlapping and distinct genes associated with heavy drinking and alcoholism
In the largest-ever genome-wide association study of both traits in the same population, a team of researchers found 18 genetic variants of significance associated with either heavy alcohol consumption, AUD, or both.
In the News
Scientists break the rules of reproduction by breeding mice from single-sex parents
The Perelman School of Medicine’s Marisa Bartolomei offered commentary on same-sex reproductive experiments, which have proven easier in bimaternal than bipaternal pairings.
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Elizabeth Warren’s DNA test: How reliable is it? A Penn prof explains
Theodore Schurr of the School of Arts and Sciences said U.S. Sen. Elizabeth Warren’s genetic analysis, which used indigenous DNA samples from Peru, Mexico, and Colombia as reference points, was legitimate due to historical migration patterns.
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