Identifying genes that keep cancer from spreading Histopathology tissue sections of the normal colon (left) showing highly organized cell-cell junctions (red) and proliferative zones (green) in colonic crypts. In contrast, a colon adenocarcinoma (right) is highly disorganized, with inconsistent cell junctions that can ultimately contribute to metastatic dissemination.(Image: Maggie Robertson) Identifying genes that keep cancer from spreading Using a novel approach, Penn Vet’s Chris Lengner and M. Andrés Blanco and colleagues have identified two genes that suppress colorectal cancer metastasis. 3 min. read
Thankful for breakthroughs in gene therapy Penn In the News The Washington Post Thankful for breakthroughs in gene therapy In an editorial, Penn Medicine and CHOP are lauded for the successful treatment of a baby born with a genetic liver deficiency. Penn and CHOP will test gene therapy for rare diseases with a new FDA trial protocol Penn In the News Philadelphia Inquirer Penn and CHOP will test gene therapy for rare diseases with a new FDA trial protocol A team led by Kiran Musunuru and Rebecca Ahrens-Nicklas of the Perelman School of Medicine and Children’s Hospital of Philadelphia will test the CRISPR framework for treating customized gene therapies for urea cycle disorders related to any one of seven genes. Wild birds are driving the current U.S. bird flu outbreak Image: wellsie82 via Getty Images Wild birds are driving the current U.S. bird flu outbreak Penn Vet’s Louise Moncla has tracked H5N1 viruses in North America to better understand the role wild birds play in the current bird flu outbreak. 4 min. read CRISPR gene-editing works to reduce high cholesterol in a new study Penn In the News NPR CRISPR gene-editing works to reduce high cholesterol in a new study Kiran Musunuru of the Perelman School of Medicine comments on CRISPR gene-editing as a way to reduce cholesterol. How a ‘one and done’ gene-editing treatment could lower cholesterol Penn In the News The Washington Post How a ‘one and done’ gene-editing treatment could lower cholesterol Kiran Musunuru of the Perelman School of Medicine comments on a study that proved a single CRISPR gene-editing treatment at the highest dose could lower cholesterol. Gene editing helped one baby—could it help thousands? Penn In the News Scientific American Gene editing helped one baby—could it help thousands? Kiran Musunuru and Rebecca Ahrens-Nicklas of the Perelman School of Medicine are attempting to shorten the length of a cutting-edge gene-editing therapy, previously produced in a record-breaking six months. Kiran Musunuru: Editing genes to save lives Kiran Musunuru: Editing genes to save lives Kiran Musunuru develops gene-based therapies to improve the health of patients with heart disease and correct genetic changes in people affected by ultra-rare conditions. Genetic testing isn’t common in adults. A new Penn study shows it should be Penn In the News Philadelphia Inquirer Genetic testing isn’t common in adults. A new Penn study shows it should be A study from the Perelman School of Medicine points to the advantages of universal genetic testing in intensive-care units. Theodore Drivas is quoted. Penn-developed AI tools and datasets help tailor treatments for kidney patients Image: Natali_Mis via Getty Images Penn-developed AI tools and datasets help tailor treatments for kidney patients Penn Medicine and Wharton researchers have partnered to create CellSpectra and SISKA, offering clues to better treatments for kidney disease and beyond. 2 min. read Load More
Penn and CHOP will test gene therapy for rare diseases with a new FDA trial protocol Penn In the News Philadelphia Inquirer Penn and CHOP will test gene therapy for rare diseases with a new FDA trial protocol A team led by Kiran Musunuru and Rebecca Ahrens-Nicklas of the Perelman School of Medicine and Children’s Hospital of Philadelphia will test the CRISPR framework for treating customized gene therapies for urea cycle disorders related to any one of seven genes. Wild birds are driving the current U.S. bird flu outbreak Image: wellsie82 via Getty Images Wild birds are driving the current U.S. bird flu outbreak Penn Vet’s Louise Moncla has tracked H5N1 viruses in North America to better understand the role wild birds play in the current bird flu outbreak. 4 min. read CRISPR gene-editing works to reduce high cholesterol in a new study Penn In the News NPR CRISPR gene-editing works to reduce high cholesterol in a new study Kiran Musunuru of the Perelman School of Medicine comments on CRISPR gene-editing as a way to reduce cholesterol. How a ‘one and done’ gene-editing treatment could lower cholesterol Penn In the News The Washington Post How a ‘one and done’ gene-editing treatment could lower cholesterol Kiran Musunuru of the Perelman School of Medicine comments on a study that proved a single CRISPR gene-editing treatment at the highest dose could lower cholesterol. Gene editing helped one baby—could it help thousands? Penn In the News Scientific American Gene editing helped one baby—could it help thousands? Kiran Musunuru and Rebecca Ahrens-Nicklas of the Perelman School of Medicine are attempting to shorten the length of a cutting-edge gene-editing therapy, previously produced in a record-breaking six months. Kiran Musunuru: Editing genes to save lives Kiran Musunuru: Editing genes to save lives Kiran Musunuru develops gene-based therapies to improve the health of patients with heart disease and correct genetic changes in people affected by ultra-rare conditions. Genetic testing isn’t common in adults. A new Penn study shows it should be Penn In the News Philadelphia Inquirer Genetic testing isn’t common in adults. A new Penn study shows it should be A study from the Perelman School of Medicine points to the advantages of universal genetic testing in intensive-care units. Theodore Drivas is quoted. Penn-developed AI tools and datasets help tailor treatments for kidney patients Image: Natali_Mis via Getty Images Penn-developed AI tools and datasets help tailor treatments for kidney patients Penn Medicine and Wharton researchers have partnered to create CellSpectra and SISKA, offering clues to better treatments for kidney disease and beyond. 2 min. read Load More
Wild birds are driving the current U.S. bird flu outbreak Image: wellsie82 via Getty Images Wild birds are driving the current U.S. bird flu outbreak Penn Vet’s Louise Moncla has tracked H5N1 viruses in North America to better understand the role wild birds play in the current bird flu outbreak. 4 min. read
CRISPR gene-editing works to reduce high cholesterol in a new study Penn In the News NPR CRISPR gene-editing works to reduce high cholesterol in a new study Kiran Musunuru of the Perelman School of Medicine comments on CRISPR gene-editing as a way to reduce cholesterol. How a ‘one and done’ gene-editing treatment could lower cholesterol Penn In the News The Washington Post How a ‘one and done’ gene-editing treatment could lower cholesterol Kiran Musunuru of the Perelman School of Medicine comments on a study that proved a single CRISPR gene-editing treatment at the highest dose could lower cholesterol. Gene editing helped one baby—could it help thousands? Penn In the News Scientific American Gene editing helped one baby—could it help thousands? Kiran Musunuru and Rebecca Ahrens-Nicklas of the Perelman School of Medicine are attempting to shorten the length of a cutting-edge gene-editing therapy, previously produced in a record-breaking six months. Kiran Musunuru: Editing genes to save lives Kiran Musunuru: Editing genes to save lives Kiran Musunuru develops gene-based therapies to improve the health of patients with heart disease and correct genetic changes in people affected by ultra-rare conditions. Genetic testing isn’t common in adults. A new Penn study shows it should be Penn In the News Philadelphia Inquirer Genetic testing isn’t common in adults. A new Penn study shows it should be A study from the Perelman School of Medicine points to the advantages of universal genetic testing in intensive-care units. Theodore Drivas is quoted. Penn-developed AI tools and datasets help tailor treatments for kidney patients Image: Natali_Mis via Getty Images Penn-developed AI tools and datasets help tailor treatments for kidney patients Penn Medicine and Wharton researchers have partnered to create CellSpectra and SISKA, offering clues to better treatments for kidney disease and beyond. 2 min. read Load More
How a ‘one and done’ gene-editing treatment could lower cholesterol Penn In the News The Washington Post How a ‘one and done’ gene-editing treatment could lower cholesterol Kiran Musunuru of the Perelman School of Medicine comments on a study that proved a single CRISPR gene-editing treatment at the highest dose could lower cholesterol. Gene editing helped one baby—could it help thousands? Penn In the News Scientific American Gene editing helped one baby—could it help thousands? Kiran Musunuru and Rebecca Ahrens-Nicklas of the Perelman School of Medicine are attempting to shorten the length of a cutting-edge gene-editing therapy, previously produced in a record-breaking six months. Kiran Musunuru: Editing genes to save lives Kiran Musunuru: Editing genes to save lives Kiran Musunuru develops gene-based therapies to improve the health of patients with heart disease and correct genetic changes in people affected by ultra-rare conditions. Genetic testing isn’t common in adults. A new Penn study shows it should be Penn In the News Philadelphia Inquirer Genetic testing isn’t common in adults. A new Penn study shows it should be A study from the Perelman School of Medicine points to the advantages of universal genetic testing in intensive-care units. Theodore Drivas is quoted. Penn-developed AI tools and datasets help tailor treatments for kidney patients Image: Natali_Mis via Getty Images Penn-developed AI tools and datasets help tailor treatments for kidney patients Penn Medicine and Wharton researchers have partnered to create CellSpectra and SISKA, offering clues to better treatments for kidney disease and beyond. 2 min. read Load More
Gene editing helped one baby—could it help thousands? Penn In the News Scientific American Gene editing helped one baby—could it help thousands? Kiran Musunuru and Rebecca Ahrens-Nicklas of the Perelman School of Medicine are attempting to shorten the length of a cutting-edge gene-editing therapy, previously produced in a record-breaking six months. Kiran Musunuru: Editing genes to save lives Kiran Musunuru: Editing genes to save lives Kiran Musunuru develops gene-based therapies to improve the health of patients with heart disease and correct genetic changes in people affected by ultra-rare conditions. Genetic testing isn’t common in adults. A new Penn study shows it should be Penn In the News Philadelphia Inquirer Genetic testing isn’t common in adults. A new Penn study shows it should be A study from the Perelman School of Medicine points to the advantages of universal genetic testing in intensive-care units. Theodore Drivas is quoted. Penn-developed AI tools and datasets help tailor treatments for kidney patients Image: Natali_Mis via Getty Images Penn-developed AI tools and datasets help tailor treatments for kidney patients Penn Medicine and Wharton researchers have partnered to create CellSpectra and SISKA, offering clues to better treatments for kidney disease and beyond. 2 min. read Load More
Kiran Musunuru: Editing genes to save lives Kiran Musunuru: Editing genes to save lives Kiran Musunuru develops gene-based therapies to improve the health of patients with heart disease and correct genetic changes in people affected by ultra-rare conditions.
Genetic testing isn’t common in adults. A new Penn study shows it should be Penn In the News Philadelphia Inquirer Genetic testing isn’t common in adults. A new Penn study shows it should be A study from the Perelman School of Medicine points to the advantages of universal genetic testing in intensive-care units. Theodore Drivas is quoted. Penn-developed AI tools and datasets help tailor treatments for kidney patients Image: Natali_Mis via Getty Images Penn-developed AI tools and datasets help tailor treatments for kidney patients Penn Medicine and Wharton researchers have partnered to create CellSpectra and SISKA, offering clues to better treatments for kidney disease and beyond. 2 min. read
Penn-developed AI tools and datasets help tailor treatments for kidney patients Image: Natali_Mis via Getty Images Penn-developed AI tools and datasets help tailor treatments for kidney patients Penn Medicine and Wharton researchers have partnered to create CellSpectra and SISKA, offering clues to better treatments for kidney disease and beyond. 2 min. read