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Linking genomics to evolution to ecology, the work takes an unusual approach to reveal broad implications of how species adapt to their local environment.
In the largest study of its kind, researchers led by PIK Professor Sarah Tishkoff, Matthew Hansen, and Meagan Rubel investigated the gut microbiomes of people from Botswana and Tanzania, and illuminate the impact of lifestyle, geography, and genetics in shaping the microbiome.
In a new study, a team of researchers have demonstrated—using fat cells derived from human stem cells—that individual genetic variation can be used to predict whether the TZD rosiglitazone will produce the unwanted side effect of increasing cholesterol levels in certain individuals.
A new stem cell-based test aims to decrease the uncertainty of gene variants and their affect on a patient’s health.
A new study answers a fundamental question in human evolution about how and where hair grows on the body, and reveals the existence of a naturally-occurring inhibitor to hair growth.
Gene therapies have had success in treating blindness but can’t save areas of the retina where cells have already died. In a new effort, School of Veterinary Medicine scientists John Wolfe and William Beltran will attempt to develop a stem-cell-based approach that restores vision.
A Penn Medicine and CHOP team shows the first example of using base-editing tools to treat a disease in animal models in utero.
The Molecular Integration in Neurological Diagnosis (MIND) Initiative is working to understand the nature of Parkinson's disease with molecular-level accuracy, so doctors can treat the root cause.
More than 150 different mutations in the light-sensing molecule rhodopsin can cause retinitis pigmentosa, characterized by a progressive loss of night and peripheral vision, and a team of researchers have developed a treatment for the condition. Successful results in dogs set the stage for testing in humans.
Researchers at Penn and the Ludwig Institute for Cancer Research discovered that a mutation in the epidermal growth receptor gene indicates a severe glioblastoma, and targeting this particular gene may further treatment.
The Perelman School of Medicine’s Marisa Bartolomei offered commentary on same-sex reproductive experiments, which have proven easier in bimaternal than bipaternal pairings.
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Theodore Schurr of the School of Arts and Sciences said U.S. Sen. Elizabeth Warren’s genetic analysis, which used indigenous DNA samples from Peru, Mexico, and Colombia as reference points, was legitimate due to historical migration patterns.
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