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Using CRISPR gene editing, a team from Penn Medicine and Children’s Hospital of Philadelphia have thwarted a lethal lung disease, in which a harmful mutation causes death within hours after birth.
Vice Provost for Faculty Anita Allen of the Law School and the School of Arts and Sciences, Daniel Rader of the Perelman School of Medicine, and Zeid Ra’ad Al Hussein of Perry World House join a group recognized for their world-class leadership and expertise.
In the largest-ever genome-wide association study of both traits in the same population, a team of researchers found 18 genetic variants of significance associated with either heavy alcohol consumption, AUD, or both.
The majority of lupus patients are female, and new findings from Montserrat Anguera of the School of Veterinary Medicine and colleagues shed light on why. The research suggests that female lupus patients don’t fully silence their second X chromosome in T cells, leading to an immune response gone awry.
In a commentary in the journal Cell, PIK Professor Sarah Tishkoff and Giorgio Sirugo shine a light on the lack of ethnic diversity represented in genomic studies, and the consequences for health and medicine.
The International Genomic Alzheimer’s Project analyzed information from more than 94,000 individuals and found new information on the underlying causes of Alzheimer disease, including five new genes that increase risk for the disease.
Whether you’re a night owl or a morning lark could affect your risk of developing a psychiatric disorder.
PIK Professor Sarah Tishkoff, Laura Scheinfeldt, and Sameer Soi use data from 50 populations to study African genetic diversity. Their analysis suggests that geographically far-flung hunter-gatherer groups share a common ancestry.
Linking genomics to evolution to ecology, the work takes an unusual approach to reveal broad implications of how species adapt to their local environment.
In the largest study of its kind, researchers led by PIK Professor Sarah Tishkoff, Matthew Hansen, and Meagan Rubel investigated the gut microbiomes of people from Botswana and Tanzania, and illuminate the impact of lifestyle, geography, and genetics in shaping the microbiome.
The Perelman School of Medicine’s Marisa Bartolomei offered commentary on same-sex reproductive experiments, which have proven easier in bimaternal than bipaternal pairings.
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Theodore Schurr of the School of Arts and Sciences said U.S. Sen. Elizabeth Warren’s genetic analysis, which used indigenous DNA samples from Peru, Mexico, and Colombia as reference points, was legitimate due to historical migration patterns.
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