Genetics

Correcting night blindness in dogs

Researchers in the School of Veterinary Medicine and colleagues have developed a gene therapy that restores dim-light vision in dogs with a congenital form of night blindness, offering hope for treating a similar condition in people.

Katherine Unger Baillie

Moving past conflation of race and genetics

Race is not genetic. Race is a social and political construct. However, the conflation of race and genetics is one way that racism persists in medicine and research.

From Penn Nursing News



In the News


Science Daily

Genomic differences selected through evolution may offer clues as to why COVID-19 outcomes vary widely

PIK Professor Sarah Tishkoff explains how her team’s studies use what happens in nature and signatures of natural selection to identify functionally important variants

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Neuroscience

Both nature and nurture contribute to signatures of socioeconomic status in the brain

Gideon Nave of the Wharton School and Martha Farah of the School of Arts & Sciences are quoted on their work that found evidence that both genetics and environmental influences contribute to the impact of socioeconomic status in a complex interplay with effects that span a variety of brain regions.

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Science

First gene-editing treatment injected into the blood reduces toxic protein for up to 1 year

Kiran Musunuru of the Perelman School of Medicine commented on an experimental gene-editing treatment for a condition that has already responded well to approved drugs. “I think people are generally assuming that the clinical outcomes [from the gene-editing treatment] will follow,” he said.

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Philadelphia Inquirer

Home DNA tests can lead to shock and trauma, but mental health resources are scarce

Dana Farengo Clark of the Abramson Cancer Center said many people come into the Center looking for support after taking a home DNA test that revealed their risk, as well as family members’ risk, for cancer. “A piece of the psychology of this is not only getting the result for yourself but then being the gatekeeper of that information,” she said.

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Scientific American

Four success stories in gene therapy

Jean Bennett and Albert Maguire of the Perelman School of Medicine developed a gene therapy to treat blindness in patients with retinal dystrophy caused by mutations in the RPE65 gene. “These people can now do things they never could have dreamed of doing, and they’re more independent and enjoying life,” said Bennett.

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The Scientist

Signaling dynamics fine-tune gene expressiong

Lukasz Bugaj of the School of Engineering & Applied Science comments on a systematic and quantitative look at how gene information is transmitted and what can influence the amount of expression.

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