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Genetics

Understanding diabetes and oral health
Two students in lab coats surround a professor in a suit.

From left: Su Ah Kim, professor of periodontics Dana Graves, and Sanan Gueyikian.

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Understanding diabetes and oral health

Two undergraduates, supported by PURM, worked on research projects this summer with the Graves Lab to contribute to the knowledge of diabetes’ impact on oral wound healing and periodontal disease.
Study of gender-affirming care reveals immune system sex differences
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Study of gender-affirming care reveals immune system sex differences

Montserrat Anguera of the Perelman School of Medicine and the School of Veterinary Medicine comments on the work to comprehensively examine the impact of gender-affirming care on the immune system.

Uncovering new antibiotics inside the human gut
Microscopic rendering of bacterial in the small intestines.

Image: iStock/ChrisChrisW

Uncovering new antibiotics inside the human gut

Researchers from Penn Engineering, led by César de la Fuente, have leveraged AI to discover dozens of potential new antibiotics in the human gut microbiome.

Ian Scheffler

How deadly parasites choose to be male
Transcription atlas of Cryptosporidium life cycle.

Penn Vet researchers developed the Cryptosporidium single-cell atlas, revealing which genes are expressed at which points across the parasite’s life cycle. On the left, the atlas shows parasites replicating asexually in green, with males in blue and females in pink. On the right, micrographs of the stages are shown, with their nuclei highlighted in green.

(Image: Boris Striepen)

How deadly parasites choose to be male

Penn Vet researchers reveal the gene expression across the life cycle of Cryptosporidium and identify the determinant of maleness.
Scientists discover a key quality-control mechanism in DNA replication
Illustration of the 55LCC complex.

Illustration of the 55LCC complex.

(Image: Courtesy of Cameron Baines/Phospho Biomedical Animation)

Scientists discover a key quality-control mechanism in DNA replication

New research from Penn Medicine advances the understanding of DNA replication and could have relevance for neurologic diseases and other conditions.

Meagan Raeke

A novel technique to form human artificial chromosomes
Microscopic view of DNA.

Image: iStock/Mohammed Haneefa Nizamudeen

A novel technique to form human artificial chromosomes

Penn researchers say the new technique for making human artificial chromosomes from single, long constructs of designer DNA will allow for more efficient laboratory research.

Alex Gardner