How deadly parasites choose to be male Penn Vet researchers developed the Cryptosporidium single-cell atlas, revealing which genes are expressed at which points across the parasite’s life cycle. On the left, the atlas shows parasites replicating asexually in green, with males in blue and females in pink. On the right, micrographs of the stages are shown, with their nuclei highlighted in green.(Image: Boris Striepen) How deadly parasites choose to be male Penn Vet researchers reveal the gene expression across the life cycle of Cryptosporidium and identify the determinant of maleness.
Scientists discover a key quality-control mechanism in DNA replication Illustration of the 55LCC complex. (Image: Courtesy of Cameron Baines/Phospho Biomedical Animation) Scientists discover a key quality-control mechanism in DNA replication New research from Penn Medicine advances the understanding of DNA replication and could have relevance for neurologic diseases and other conditions.
A novel technique to form human artificial chromosomes Image: iStock/Mohammed Haneefa Nizamudeen A novel technique to form human artificial chromosomes Penn researchers say the new technique for making human artificial chromosomes from single, long constructs of designer DNA will allow for more efficient laboratory research.
Mega-analysis identifies gene variants associated with glaucoma in people of African ancestry Image: iStock/DragonImages Mega-analysis identifies gene variants associated with glaucoma in people of African ancestry A Penn Medicine analysis aims to fill knowledge gaps and help guide clinical decisions for a group particularly vulnerable to developing glaucoma.
Two-and-a-half decades of research in Malawi Collaborators on the Malawi Longitudinal Study of Families and Health visited the University of Pennsylvania in October for a project meeting. Pictured are Lauren Schmitz (University of Wisconsin-Madison), Namrata Ray (Penn), Hans-Peter Kohler (Penn), Kondwani Katundu (Kamuzu University of Health Sciences in Malawi), Kazione Kulisewa (Kamuzu University), Iliana V. Kohler (Penn), and Victor Mwapasa (Kamuzu University).(Image: Eric Sucar) Two-and-a-half decades of research in Malawi As the country’s life expectancy has risen, the Malawi Longitudinal Study of Families and Health has shifted its current and future research to aging.
More than skin deep: A molecular and mechanistic look at pigmentation variation PIK Professor Sarah Tishkoff led a collaborative team of researchers who have discovered key insights into the molecular basis of skin color differences among Africans. “There’s so much genetic diversity in African populations, but they’ve also been historically underrepresented in studies,” Tishkoff says. “Our findings offer more information on these populations and paint a clearer picture of human evolution.” (Image: Courtesy of Sarah Tishkoff and Alessia Ranciaro) More than skin deep: A molecular and mechanistic look at pigmentation variation A new collaborative study offers a better understanding of genes and variants responsible for skin color, providing insights into human evolution and local adaptation.
FDA approves two sickle cell therapies, including first CRISPR medicine Penn In the News The Washington Post FDA approves two sickle cell therapies, including first CRISPR medicine Kiran Musunuru of the Perelman School of Medicine says that gene editing will be the biggest story of the century. More than 260,000 Penn Medicine patients have agreed to share their DNA for research, and the discoveries are just getting started Penn In the News Philadelphia Inquirer More than 260,000 Penn Medicine patients have agreed to share their DNA for research, and the discoveries are just getting started More than 260,000 people have signed up to participate in Penn Medicine BioBank, co-directed by Marilyn Ritchie and Dan Rader, which cross-references DNA with electronic health records to discover genetic variants of medical conditions. Jim Wilson has two new promising gene therapy studies, but says investment in the cutting-edge field has ‘gotten worse’ Penn In the News Philadelphia Inquirer Jim Wilson has two new promising gene therapy studies, but says investment in the cutting-edge field has ‘gotten worse’ Jim Wilson of the Perelman School of Medicine has published two new studies supporting the promise of cutting-edge gene therapy, finding evidence that the genetic treatments can be beneficial for years without raising the risk of cancer. Neanderthals carried genes acquired from ancient interactions with ‘cousins’ of modern humans Members of Tishkoff's research team collecting ethnograpgic information from participants in Ethiopia. (Image: Courtesy of Sarah Tishkoff) Neanderthals carried genes acquired from ancient interactions with ‘cousins’ of modern humans A new collaborative study led by Sarah Tishkoff shows that Neanderthals inherited at least 6% of their genome from a now-extinct lineage of early modern humans. Load More
More than 260,000 Penn Medicine patients have agreed to share their DNA for research, and the discoveries are just getting started Penn In the News Philadelphia Inquirer More than 260,000 Penn Medicine patients have agreed to share their DNA for research, and the discoveries are just getting started More than 260,000 people have signed up to participate in Penn Medicine BioBank, co-directed by Marilyn Ritchie and Dan Rader, which cross-references DNA with electronic health records to discover genetic variants of medical conditions. Jim Wilson has two new promising gene therapy studies, but says investment in the cutting-edge field has ‘gotten worse’ Penn In the News Philadelphia Inquirer Jim Wilson has two new promising gene therapy studies, but says investment in the cutting-edge field has ‘gotten worse’ Jim Wilson of the Perelman School of Medicine has published two new studies supporting the promise of cutting-edge gene therapy, finding evidence that the genetic treatments can be beneficial for years without raising the risk of cancer. Neanderthals carried genes acquired from ancient interactions with ‘cousins’ of modern humans Members of Tishkoff's research team collecting ethnograpgic information from participants in Ethiopia. (Image: Courtesy of Sarah Tishkoff) Neanderthals carried genes acquired from ancient interactions with ‘cousins’ of modern humans A new collaborative study led by Sarah Tishkoff shows that Neanderthals inherited at least 6% of their genome from a now-extinct lineage of early modern humans. Load More
Jim Wilson has two new promising gene therapy studies, but says investment in the cutting-edge field has ‘gotten worse’ Penn In the News Philadelphia Inquirer Jim Wilson has two new promising gene therapy studies, but says investment in the cutting-edge field has ‘gotten worse’ Jim Wilson of the Perelman School of Medicine has published two new studies supporting the promise of cutting-edge gene therapy, finding evidence that the genetic treatments can be beneficial for years without raising the risk of cancer. Neanderthals carried genes acquired from ancient interactions with ‘cousins’ of modern humans Members of Tishkoff's research team collecting ethnograpgic information from participants in Ethiopia. (Image: Courtesy of Sarah Tishkoff) Neanderthals carried genes acquired from ancient interactions with ‘cousins’ of modern humans A new collaborative study led by Sarah Tishkoff shows that Neanderthals inherited at least 6% of their genome from a now-extinct lineage of early modern humans.
Neanderthals carried genes acquired from ancient interactions with ‘cousins’ of modern humans Members of Tishkoff's research team collecting ethnograpgic information from participants in Ethiopia. (Image: Courtesy of Sarah Tishkoff) Neanderthals carried genes acquired from ancient interactions with ‘cousins’ of modern humans A new collaborative study led by Sarah Tishkoff shows that Neanderthals inherited at least 6% of their genome from a now-extinct lineage of early modern humans.