11/15
Genetics
Do DIY DNA kits revive a harmful perceived link between genetics and race?
Do DIY DNA kits revive a harmful perceived link between genetics and race?
Research from sociologist Wendy Roth reveals that on average, these tests don’t reinforce the idea of essentialism, but how much participants know about genetics going in matters.
Uncovering a defective sperm epigenome that leads to male infertility
Uncovering a defective sperm epigenome that leads to male infertility
A new mouse model allows researchers to track defective sperm and potentially find ways to correct it.
This genetic variant is underdiagnosed, under-recognized, and deadly
This genetic variant is underdiagnosed, under-recognized, and deadly
A genetic variant which is found in about 3 percent of individuals of African ancestry is a more significant cause of heart failure than previously believed, according to a multi-institution study led by researchers at Penn Medicine.
The view from inside the ‘medical scandal’ of China’s gene-edited babies
The view from inside the ‘medical scandal’ of China’s gene-edited babies
In a Q&A, geneticist Kiran Musunuru describes his unintentional connection to the scientist behind the scandal and the book that came out of the experience.
Reprogramming ant ‘soldiers’
Reprogramming ant ‘soldiers’
A Penn study reveals the epigenetic pathway that controls social behavior in carpenter ants, finding that the ants reprogram up to five days after they hatch, while reprogramming was ineffective at the 10-day mark.
Genes play a role in dog breed differences in behavior
Genes play a role in dog breed differences in behavior
Border collies are highly trainable, greyhounds love to chase, and German shepherds make good guard dogs. While the environment plays a role, traits like these are highly heritable. A new study identifies 131 genetic variants associated with breed differences in behavior.
Fruit flies’ microbiomes shape their evolution
Fruit flies’ microbiomes shape their evolution
In just five generations, an altered microbiome can lead to genome-wide evolution in fruit flies, according to new research led by Paul Schmidt and postdoc Seth Rudman of the School of Arts and Sciences.
Is treatment forever? Success of gene therapy for inherited blindness depends on timing
Is treatment forever? Success of gene therapy for inherited blindness depends on timing
An FDA-approved gene therapy for Leber congenital amaurosis, an inherited vision disorder with a childhood onset and progressive nature, has improved patients’ sight. But new research underscores the importance of further investigation to halt the progression of the disorder.
A molecular ‘atlas’ of animal development
A molecular ‘atlas’ of animal development
Scientists have studied the nematode worm Caenorhabditis elegans for decades, making essential contributions to basic science. In the latest milestone, a team uses cutting-edge technology to individually profile the genes expressed in more than 80,000 cells in a developing C. elegans embryo.
Cardiac genetic mutation may not always predict heart disease
Cardiac genetic mutation may not always predict heart disease
Researchers at Penn Medicine and Geisinger find only 5% of patients with a mutation of the TTN gene have dilated cardiomyopathy, despite changes in heart function.
In the News
Philadelphia Inquirer
A Philly biotech got $60M from a TED initiative for AI in medicine
David Fajgenbaum of the Perelman School of Medicine helped found Every Cure, a biotechnology nonprofit that employs AI to help match existing treatments to new diseases.
FULL STORY →
Stat
Study of gender-affirming care reveals immune system sex differences
Montserrat Anguera of the Perelman School of Medicine and the School of Veterinary Medicine comments on the work to comprehensively examine the impact of gender-affirming care on the immune system.
FULL STORY →
The New York Times
A disease that makes children age rapidly gets closer to a cure
Kiran Musunuru of the Perelman School of Medicine says there’s no guarantee that gene editing which worked well in mice will also work with human patients.
FULL STORY →
USA Today
She’s fighting to stop the brain disease that killed her mother before it gets her
Kiran Musunuru of the Perelman School of Medicine comments on shutting off genetic signals in the brain to hold off diseases.
FULL STORY →
The Washington Post
FDA approves two sickle cell therapies, including first CRISPR medicine
Kiran Musunuru of the Perelman School of Medicine says that gene editing will be the biggest story of the century.
FULL STORY →
Philadelphia Inquirer
More than 260,000 Penn Medicine patients have agreed to share their DNA for research, and the discoveries are just getting started
More than 260,000 people have signed up to participate in Penn Medicine BioBank, co-directed by Marilyn Ritchie and Dan Rader, which cross-references DNA with electronic health records to discover genetic variants of medical conditions.
FULL STORY →