New data reveals cell size sparks genome awakening in embryos
An innovative study provides a new perspective on how a zygote transitions from maternal to zygotic control, uncovering how an embryo “recognizes” when to undergo this transition.
The transcription factor p63 establishes epithelial enhancers at genes crucial to epithelial cell identity. (Photo courtesy: Enrique Lin-Shiao, Penn Medicine)
The mystery behind cleft palate and lips
New research identifies 100 new risk genes that could lead to the development of cleft lip and palate, combining molecular findings with genome data to find that many of the genes that are highly associated with clefting are located near the enhancer regions that work with a specific protein.
Blotchy black regions of a nucleus (left), with normal chromatin compaction (denoted by black spots). Nucleus deficient in the enzymes (right). (Photo credit: Dario Nicetto)
Cell development discovery changes our understanding of how genes shape early embryos
To fit inside each nucleus, DNA coils around specialized proteins. These spools of wrapped DNA inhibit gene regulatory proteins from binding to protein-coding stretches along the genome, which help keep genes in the “off” position when they’re not needed.
The Perelman School of Medicine’s James Wilson discussed possible venues for the scientific oversight of controversial research. The FDA could be a good option, he suggested, but the organization would have to change its confidentiality restrictions to supervise effectively.
Elizabeth Warren’s DNA test: How reliable is it? A Penn prof explains
Theodore Schurr of the School of Arts and Sciences said U.S. Sen. Elizabeth Warren’s genetic analysis, which used indigenous DNA samples from Peru, Mexico, and Colombia as reference points, was legitimate due to historical migration patterns.
Scientists break the rules of reproduction by breeding mice from single-sex parents
The Perelman School of Medicine’s Marisa Bartolomei offered commentary on same-sex reproductive experiments, which have proven easier in bimaternal than bipaternal pairings.
The new Center for Sub-Cellular Genomics will be at the forefront of new technologies for studying the dynamics of genomic interactions within a single cell.
New center will study the complex genomics within individual cells
Junhyong Kim and James Eberwine are leading a multi-disciplinary team in developing cutting-edge technologies that can assess the genetic material inside individual compartments of single cells. The new Center for Sub-Cellular Genomics aims to revolutionize therapies for diseases such as bipolar disorder, autism, and Alzheimer’s disease.
Finding patterns in a class of neurological disorders
Research from Penn Engineering and the Perelman School of Medicine has found that the shared pattern is misfolded in Fragile X Syndrome, a member of the class of disorders that also includes ALS and Huntington’s disease
