2025 Benjamin Franklin Parkway
A team from the University of Pennsylvania analyzed genomic data from global populations, including thousands of ethnically diverse Africans, to identify genetic variants that may be associated with clinical COVID-19 outcomes.
While gene mutations can lead to drug resistance, researchers in the Perelman School of Medicine have identified an important, non-genetic adaptation that could also drive resistance to targeted therapy in T cell leukemia, a type of blood cell cancer.
An interdisciplinary team of Penn researchers have used a carefully designed algorithm to discover a new suite of antimicrobial peptides, or naturally occurring antibiotics, in the human genome.
A physician-scientist, Jain treats patients as a cardiologist in addition to seeking new knowledge about stem cell biology, heart development, and genome organization in his lab.
A new Penn Medicine study shows that changes in a DNA sequence may cause chromosomes to misfold in a way that elevates the risk for autoimmune diseases.
An innovative study provides a new perspective on how a zygote transitions from maternal to zygotic control, uncovering how an embryo “recognizes” when to undergo this transition.
A team of microbiologists and pulmonologists at Penn have scanned genome databases and found a new abundant viral family associated with disease.
New research identifies 100 new risk genes that could lead to the development of cleft lip and palate, combining molecular findings with genome data to find that many of the genes that are highly associated with clefting are located near the enhancer regions that work with a specific protein.
The School of Veterinary Medicine’s Center for Host-Microbial Interactions helps researchers delving into ‘omics’ to promote animal and human health.
To fit inside each nucleus, DNA coils around specialized proteins. These spools of wrapped DNA inhibit gene regulatory proteins from binding to protein-coding stretches along the genome, which help keep genes in the “off” position when they’re not needed.
The Perelman School of Medicine’s James Wilson discussed possible venues for the scientific oversight of controversial research. The FDA could be a good option, he suggested, but the organization would have to change its confidentiality restrictions to supervise effectively.
FULL STORY →
Theodore Schurr of the School of Arts and Sciences said U.S. Sen. Elizabeth Warren’s genetic analysis, which used indigenous DNA samples from Peru, Mexico, and Colombia as reference points, was legitimate due to historical migration patterns.
FULL STORY →
The Perelman School of Medicine’s Marisa Bartolomei offered commentary on same-sex reproductive experiments, which have proven easier in bimaternal than bipaternal pairings.
FULL STORY →