Through
12/15
PIK Professor Michael Platt and collaborators have generated the first single-cell “atlas” of the primate brain to help explore links between molecules, cells, brain function, and disease.
The findings, from a team led by Golnaz Vahedi of Penn Medicine, could have implications for T-cell based immunotherapies for cancer and other conditions.
A team from the University of Pennsylvania analyzed genomic data from global populations, including thousands of ethnically diverse Africans, to identify genetic variants that may be associated with clinical COVID-19 outcomes.
While gene mutations can lead to drug resistance, researchers in the Perelman School of Medicine have identified an important, non-genetic adaptation that could also drive resistance to targeted therapy in T cell leukemia, a type of blood cell cancer.
An interdisciplinary team of Penn researchers have used a carefully designed algorithm to discover a new suite of antimicrobial peptides, or naturally occurring antibiotics, in the human genome.
A physician-scientist, Jain treats patients as a cardiologist in addition to seeking new knowledge about stem cell biology, heart development, and genome organization in his lab.
A new Penn Medicine study shows that changes in a DNA sequence may cause chromosomes to misfold in a way that elevates the risk for autoimmune diseases.
An innovative study provides a new perspective on how a zygote transitions from maternal to zygotic control, uncovering how an embryo “recognizes” when to undergo this transition.
A team of microbiologists and pulmonologists at Penn have scanned genome databases and found a new abundant viral family associated with disease.
New research identifies 100 new risk genes that could lead to the development of cleft lip and palate, combining molecular findings with genome data to find that many of the genes that are highly associated with clefting are located near the enhancer regions that work with a specific protein.
A study by Christoph A. Thaiss of the Perelman School of Medicine and colleagues has traced two detailed molecular pathways from the brain to the gut that produce inflammatory bowel disease flare-ups.
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Iain Mathieson of the Perelman School of Medicine says that the Iceman genome was one of the first ancient human genomes ever published.
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A team of researchers from the Perelman School of Medicine found that small changes in the protein called ETS1 can lead to an increased likelihood of allergic reactions that cause inflammation.
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Stuart Isaacs of the Perelman School of Medicine speaks positively about his time studying poxviruses in Bernard Moss’ lab.
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Kiran Musunuru of the Perelman School of Medicine says that Chinese geneticist He Jiankui crossed ethical lines and exhibited bad science by editing babies’ genes.
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A study by Christoph Thaiss of the Perelman School of Medicine and colleagues identified a pathway between the brain and immune system in mice that may explain why psychological stress can worsen gut inflammation.
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