11/15
Genomics
The mystery behind cleft palate and lips
The mystery behind cleft palate and lips
New research identifies 100 new risk genes that could lead to the development of cleft lip and palate, combining molecular findings with genome data to find that many of the genes that are highly associated with clefting are located near the enhancer regions that work with a specific protein.
Demystifying genomic technology for veterinary researchers
Demystifying genomic technology for veterinary researchers
The School of Veterinary Medicine’s Center for Host-Microbial Interactions helps researchers delving into ‘omics’ to promote animal and human health.
Cell development discovery changes our understanding of how genes shape early embryos
Cell development discovery changes our understanding of how genes shape early embryos
To fit inside each nucleus, DNA coils around specialized proteins. These spools of wrapped DNA inhibit gene regulatory proteins from binding to protein-coding stretches along the genome, which help keep genes in the “off” position when they’re not needed.
New center will study the complex genomics within individual cells
New center will study the complex genomics within individual cells
Junhyong Kim and James Eberwine are leading a multi-disciplinary team in developing cutting-edge technologies that can assess the genetic material inside individual compartments of single cells. The new Center for Sub-Cellular Genomics aims to revolutionize therapies for diseases such as bipolar disorder, autism, and Alzheimer’s disease.
Finding patterns in a class of neurological disorders
Finding patterns in a class of neurological disorders
Research from Penn Engineering and the Perelman School of Medicine has found that the shared pattern is misfolded in Fragile X Syndrome, a member of the class of disorders that also includes ALS and Huntington’s disease
New insights into malaria culprit
New insights into malaria culprit
New insights from the Perelman School of Medicine on the origins of deadly infectious diseases are vital to understanding the emergence of human pathogens, and may even lead to eradicating malaria.
Genome editing reduces cholesterol in animals, humans could be next
Genome editing reduces cholesterol in animals, humans could be next
Successful genome editing trials in large primates offers an alternative treatment to reduce high cholesterol in patients who can't tolerate statins or other drug therapies.
Using statistics to uncover the truth about individual cells
Using statistics to uncover the truth about individual cells
Researchers at Penn have developed a better method for interpreting data from single-cell RNA sequencing technologies.
In the News
The Washington Post
FDA approves two sickle cell therapies, including first CRISPR medicine
Kiran Musunuru of the Perelman School of Medicine says that gene editing will be the biggest story of the century.
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Scientific American
See how stress affects inflammatory bowel disease
A study by Christoph A. Thaiss of the Perelman School of Medicine and colleagues has traced two detailed molecular pathways from the brain to the gut that produce inflammatory bowel disease flare-ups.
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Smithsonian Magazine
Famed 5,300-year-old Alps Iceman was a balding middle-aged man with dark skin and eyes
Iain Mathieson of the Perelman School of Medicine says that the Iceman genome was one of the first ancient human genomes ever published.
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Indo-Asian News Service
How our genes make us prone to allergies
A team of researchers from the Perelman School of Medicine found that small changes in the protein called ETS1 can lead to an increased likelihood of allergic reactions that cause inflammation.
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Stat
House GOP inquiry over gain-of-function research targets a scientific giant
Stuart Isaacs of the Perelman School of Medicine speaks positively about his time studying poxviruses in Bernard Moss’ lab.
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NPR
His baby gene editing shocked ethicists. Now he’s in the lab again
Kiran Musunuru of the Perelman School of Medicine says that Chinese geneticist He Jiankui crossed ethical lines and exhibited bad science by editing babies’ genes.
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