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Could gut bacteria impact your motivation to exercise?
Smithsonian Magazine

Could gut bacteria impact your motivation to exercise?

A study co-authored by Christoph Thaiss of the Perelman School of Medicine finds that the gut microbiome may affect motivation to exercise.

COVID-19 is more widespread in animals than we thought
National Geographic

COVID-19 is more widespread in animals than we thought

Frederic Bushman of the Perelman School of Medicine says that many mammalian ACE-2 receptors are proving susceptible to COVID, even if they aren’t a perfect match.

Bubonic plague left lingering scars on the human genome
Nature

Bubonic plague left lingering scars on the human genome

Ziyue Gao of the Perelman School of Medicine comments on the innovative promise of the University of Chicago’s work uncovering the Black Death’s effect on human genetics.

Genomic differences selected through evolution may offer clues as to why COVID-19 outcomes vary widely
two DNA double helixes next to an illustration of the SARS-CoV-2 virus

COVID-19’s hard-to-predict effects likely owe in part to genetic differences. A Penn-led study analyzing the genomes of a diverse set of populations globally points to genetic variants that may help explain some of the variability in disease severity.

Genomic differences selected through evolution may offer clues as to why COVID-19 outcomes vary widely

A team from the University of Pennsylvania analyzed genomic data from global populations, including thousands of ethnically diverse Africans, to identify genetic variants that may be associated with clinical COVID-19 outcomes.

Katherine Unger Baillie

A new study finds genome refolding contributes to resistance to cancer therapy
Two cartoon hands holding lines of yarn, twisted into genetic shapes.

If you stretched the DNA fiber packed inside of a single cell, it would reach six feet long from end to end—that’s like fitting a ball of yarn twice the size of Manhattan into a tennis ball. Penn researchers have discovered that the misfolding of DNA can reposition transcription factors and lead to cancer drug resistance. (Image: Penn Medicine News)

A new study finds genome refolding contributes to resistance to cancer therapy

While gene mutations can lead to drug resistance, researchers in the Perelman School of Medicine have identified an important, non-genetic adaptation that could also drive resistance to targeted therapy in T cell leukemia, a type of blood cell cancer.

Lauren Ingeno

‘Encrypted’ peptides could be wellspring of natural antibiotics
Microscopic view of an amino acid chain.

‘Encrypted’ peptides could be wellspring of natural antibiotics

An interdisciplinary team of Penn researchers have used a carefully designed algorithm to discover a new suite of antimicrobial peptides, or naturally occurring antibiotics, in the human genome.

From Penn Engineering Today

Rajan Jain’s unique journey to becoming a physician-scientist
Rajan Jain headshot.

Rajan Jain, assistant professor of Cardiovascular Medicine and Cell and Developmental Biology. (Image: Penn Medicine)

Rajan Jain’s unique journey to becoming a physician-scientist

A physician-scientist, Jain treats patients as a cardiologist in addition to seeking new knowledge about stem cell biology, heart development, and genome organization in his lab.

From Penn Medicine News