Internal Medicine | Penn Today

flames and water depicted as a balanced ring

The perfect balancing act of inflammation rests on a single molecule

A new Penn study reveals a molecular mechanism that helps the body mount balanced responses to deadly infections.

Old-fashioned alarm clock on top of an empty plate with a table setting

How our body’s internal clocks communicate may impact our overall health

Most cells contain molecular clocks, but the requirement of peripheral clocks for rhythmicity, and their effects on physiology, are not well understood. Now, a new study reveal the roles of the hepatocyte clock in cell communication and metabolism.

Outline of liver with a donut, cookie, and pastry laying on top of it and a dialog box outside the liver addressing it.

The gut shields the liver from fructose-induced damage

A new study shows how excessive consumption of fructose, whether via food or beverage, overwhelms gut defenses and results in the development of fatty liver.

To heal meniscus injuries, researchers go to the heart of a cell

Using an enzyme inhibitor in meniscus cells, a Penn team is able to soften the cells’ nucleus and promote access to previously impassible tissue.

A pair of hands using a personal blood sugar measuring device.

Researchers identify novel genetic variants linked to Type 2 diabetes

Largest-ever study of its kind finds variants that may predispose some people to develop the disease and related conditions like coronary heart disease and chronic kidney disease.

Image of a body's cell representing with the words "mimicking efferocytosis-induced signals" showing the treatment of an inflammatory disease

Stimulating immune cleanup crew offers affordable possibility for treating rare genetic disorder

Compounds that mimicked the process known as efferocytosis alleviated signs of leukocyte adhesion deficiency type-1 in an animal model, according to work led by the School of Dental Medicine’s George Hajishengallis

Organ transplants dive amid virus crisis, start to inch back

Peter Reese of the Perelman School of Medicine spoke about the resumption of organ transplants. “Transplant centers and patients really want to get going again, but there are all these questions,” he said. “We need to be finding places that maintained their transplant rates and finding out what they did.”

Researchers discover a key mechanism of cytokine storm in Castleman Disease

The discovery by Penn researchers may be applicable to COVID-19 patients, as some experience the same hyper-response of the immune system.

A promising new strategy to help broken bones heal faster

To improve how broken bones heal in people with diabetes, the School of Dental Medicine’s Henry Daniell, Sheri Yang, and colleagues are leading work to develop an affordable oral therapy—grown in plants.

microscopic view of the inside of a blood vessel

Vasculitis treatment with fewer steroids

The insights from the PEXIVAS Trial, a 10-year study, shows treatment for ANCA-associated vasculitis can become much more patient-friendly and reduces kidney failure, for which vasculitis patients are often at risk.

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