7.14
Internal Medicine
The gut shields the liver from fructose-induced damage
The gut shields the liver from fructose-induced damage
A new study shows how excessive consumption of fructose, whether via food or beverage, overwhelms gut defenses and results in the development of fatty liver.
To heal meniscus injuries, researchers go to the heart of a cell
To heal meniscus injuries, researchers go to the heart of a cell
Using an enzyme inhibitor in meniscus cells, a Penn team is able to soften the cells’ nucleus and promote access to previously impassible tissue.
Researchers identify novel genetic variants linked to Type 2 diabetes
Researchers identify novel genetic variants linked to Type 2 diabetes
Largest-ever study of its kind finds variants that may predispose some people to develop the disease and related conditions like coronary heart disease and chronic kidney disease.
Stimulating immune cleanup crew offers affordable possibility for treating rare genetic disorder
Stimulating immune cleanup crew offers affordable possibility for treating rare genetic disorder
Compounds that mimicked the process known as efferocytosis alleviated signs of leukocyte adhesion deficiency type-1 in an animal model, according to work led by the School of Dental Medicine’s George Hajishengallis
Researchers discover a key mechanism of cytokine storm in Castleman Disease
Researchers discover a key mechanism of cytokine storm in Castleman Disease
The discovery by Penn researchers may be applicable to COVID-19 patients, as some experience the same hyper-response of the immune system.
A new way to study HIV’s impact on the brain
A new way to study HIV’s impact on the brain
Using a newly developed laboratory model of three types of brain cells, Penn and CHOP scientists reveal how HIV infection—as well as the drugs that treat it—can take a toll on the central nervous system.
A promising new strategy to help broken bones heal faster
A promising new strategy to help broken bones heal faster
To improve how broken bones heal in people with diabetes, the School of Dental Medicine’s Henry Daniell, Sheri Yang, and colleagues are leading work to develop an affordable oral therapy—grown in plants.
Vasculitis treatment with fewer steroids
Vasculitis treatment with fewer steroids
The insights from the PEXIVAS Trial, a 10-year study, shows treatment for ANCA-associated vasculitis can become much more patient-friendly and reduces kidney failure, for which vasculitis patients are often at risk.
Advancing an oral drug for pulmonary arterial hypertension
Advancing an oral drug for pulmonary arterial hypertension
With a protein drug grown in the leaves of lettuce plants, the School of Dental Medicine’s Henry Daniell and colleagues hope to provide new treatment options for patients with pulmonary arterial hypertension, a rare but deadly disease.
Direct-to-consumer fertility tests confuse and mislead consumers
Direct-to-consumer fertility tests confuse and mislead consumers
Findings from the small, first-of-its-kind ethnographic study reinforce the need for consumer education around the purpose and accuracy of direct-to-consumer hormone-based fertility tests.
In the News
The New York Times
Organ transplants dive amid virus crisis, start to inch back
Peter Reese of the Perelman School of Medicine spoke about the resumption of organ transplants. “Transplant centers and patients really want to get going again, but there are all these questions,” he said. “We need to be finding places that maintained their transplant rates and finding out what they did.”
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The New York Times
Can melatonin vapes safely help people sleep?
Julio Chirinos of the Perelman School of Medicine wrote an editorial to accompany a new study about the effects of marathon running on the heart. “Exercise is great for the entire body, including the arteries,” he said.
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U.S. News & World Report
What is syphilis, and why are rates rising?
Amy Forrestel of the Perelman School of Medicine spoke about the symptoms, spread, and long-term effects of syphilis. If left untreated, the sexually transmitted infection “can wreak a lot of havoc” on the body, said Forrestel.
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Associated Press
Study: Safe to transplant hepatitis C-infected hearts, lungs
Peter Reese of the Perelman School of Medicine commented on a recent study about the safety and efficacy of pairing hepatitis C-infected organ transplants with fast, preventative treatments to block recipients from contracting the infection. The combination may work “because maybe the virus hasn’t had the chance to establish itself,” said Reese.
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Men’s Health
Why gene editing may hold the promise of a herpes cure
Sita Awasthi of the Perelman School of Medicine discussed the challenges researchers face in pursuing a cure for herpes. In spite of advances in CRISPR technology, Awasthi emphasizes the continued need for a preventive vaccine.
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Reader’s Digest
8 surprising heartburn causes you need to take seriously
Kristle Lynch of the Perelman School of Medicine described the causes, symptoms, and consequences of heartburn.
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