A cohort study comes of age A cohort study comes of age For nearly two decades, a major national study of kidney disease led and coordinated at Penn has defined key risk factors in an all-too-common silent epidemic.
Keeping parasites from sticking to mosquito guts could block disease transmission Mosquitoes infected with the parasite Crithidia fasciculata may offer a valuable model for studying other parasite diseases, according to a study led by Penn Vet’s Michael Povelones and Penn State Brandywine’s Megan Povelones. Here, a microscopic image shows the hindgut of Aedes aegypti mosquito infected with Crithidia expressing green fluorescent protein. (Image: Michael Povelones) Keeping parasites from sticking to mosquito guts could block disease transmission Researchers at the School of Veterinary Medicine show how a new model for studying the way parasites known as kinetoplastids adhere to mosquitoes’ insides could illuminate strategies for curbing diseases.
A new drug target for chemically induced Parkinson’s disease Findings from Penn Vet suggest a potential new target for treating Parkinson's, an enzyme that wreaks its damage on dopamine-producing neurons. A new drug target for chemically induced Parkinson’s disease An enzyme that modifies chemicals formed in the body by alcohol, tobacco, and certain foods may be a new target for treating Parkinson’s disease. The altered compounds may play a role in triggering the onset or advancing the progression of the neurodegenerative condition.
Novel model for studying intestinal parasite could advance vaccine development A section of intestine from an infected mouse shows Cryptosporidium tyzzeri parasites in red. The Penn Vet-led team is the first to sequence, study, and manipulate a naturally occurring mouse Cryptosporidium. (Image: Muthugapatti Kandasamy, Adam Sateriale, and Boris Striepen) Novel model for studying intestinal parasite could advance vaccine development The intestinal parasite Cryptosporidium causes frequent outbreaks in the U.S., and has been historically difficult to study. A novel model of infection from Penn Vet serves as a new tool to pursue a vaccine.
How to quell a cytokine storm How to quell a cytokine storm An international team finds new ways to dampen an overactive immune system, and can influence new drug targets for lupus and other autoimmune disorders.
We’re only as good as our microbiomes are happy We’re only as good as our microbiomes are happy Understanding the microbiome, the collection of bacteria, viruses, and fungi in the gut, is helping to sort out the intricacies of diet, chronobiology, cancer treatment, and more.
Certain strains of bacteria associated with diabetic wounds that do not heal Staphylococcus aureus bacteria Certain strains of bacteria associated with diabetic wounds that do not heal A new study finds that whether a wound like a diabetic foot ulcer heals or progresses to a worse outcome, including infection or even amputation, may depend on the microbiome within that wound.
App predicts risk of developing hernia following abdominal surgery App predicts risk of developing hernia following abdominal surgery A Penn-developed app can predict the likelihood that a patient will develop an incisional hernia following abdominal surgery, utilizing electronic health records to identify the most common risk factors for patients.
What is syphilis, and why are rates rising? U.S. News & World Report What is syphilis, and why are rates rising? Amy Forrestel of the Perelman School of Medicine spoke about the symptoms, spread, and long-term effects of syphilis. If left untreated, the sexually transmitted infection “can wreak a lot of havoc” on the body, said Forrestel.