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Drew Weissman and Katalin Karikó receive 2021 Lasker Award
Drew Weisman and Katalin Kariko wear masks in a lab and look at liquid in a test tube.

mRNA scientists Drew Weissman, the Roberts Family Professor of Vaccine Research in Penn’s Perelman School of Medicine, and Katalin Karikó, an adjunct professor of neurosurgery at Penn and a senior vice president at BioNTech. (Image: Courtesy of Penn Medicine)

Drew Weissman and Katalin Karikó receive 2021 Lasker Award

Weissman and Karikó’s mRNA technology is recognized for enabling rapid development of highly effective COVID-19 vaccines

Alex Gardner

Penn establishes the Center for Precision Engineering for Health with $100 million commitment
Microscopic biomaterials.

The Center for Precision Engineering for Health will bring together researchers spanning multiple scientific fields to develop novel therapeutic biomaterials, such as a drug-delivering nanoparticles that can be designed to adhere to only to the tissues they target. (Image: Courtesy of the Mitchell Lab)

Penn establishes the Center for Precision Engineering for Health with $100 million commitment

The Center will conduct interdisciplinary, fundamental, and translational research in biomaterials that can create breakthroughs in improving health care and saving lives, including nanoparticle technologies to improve storage and distribution of COVID-19 mRNA vaccines.

Evan Lerner

Imaging technology maps cells tied to inflammatory bowel disease
Microscopic multicolor image of a colon.

Multicolor image of a colon from a patient with ulcerative colitis stained by imaging mass cytometry. (Image: Courtesy of Ayano Kondo from the Kaestner Lab)

Imaging technology maps cells tied to inflammatory bowel disease

“Imaging mass cytometry” shows how cells tied to inflammatory bowel disease affect intestinal tissue, generating new theories for the progression of Crohn’s disease and ulcerative colitis.

From Penn Medicine News

How a diversity program enabled a childhood orthopaedics patient’s research dreams
Doctor holding up an X-ray of a spine in front of a patient, seated.

How a diversity program enabled a childhood orthopaedics patient’s research dreams

The McKay Orthopaedic Research Lab’s Diversity, Equity, and Inclusion (DEI) committee’s conference grant program offers a welcoming environment and resources that support people of all identities, to engate in orthopaedic research.

From Penn Medicine News

Test predicts which patients with rare blood disease will respond to treatment
David Fajgenbaum in his lab.

David Fajgenbaum is an assistant professor of medicine at the Perelman School of Medicine at the University of Pennsylvania and associate director of patient impact in the Penn Orphan Disease Center. He also leads the Castleman Disease Research Program.

(Image: Courtesy of Penn Medicine)

Test predicts which patients with rare blood disease will respond to treatment

A Penn Medicine study identifies blood proteins that indicate which patients with idiopathic multicentric Castleman disease are most likely to benefit from the only FDA approved treatment for the disease, and uncovers an alternative.

From Penn Medicine News

Why does asthma get worse at night?

Why does asthma get worse at night?

Garret FitzGerald of the Perelman School of Medicine weighed in on a study that linked the circadian system to nighttime asthma symptoms. “This work highlights the value of small, carefully conducted studies,” and could inform future treatments, he said.

Penn engineers will develop on-demand, on-site mRNA manufacturing
emulsions of oil and water separated by a layer of nanoparticles.

Bijels, or bicontinuous interfacially jammed emulsion gels, are structured emulsions of oil and water that are kept separated by a layer of nanoparticles. Penn Engineering researchers will develop a way of using them to manufacture mRNA-based therapeutics. (Image: Penn Engineering Today)

Penn engineers will develop on-demand, on-site mRNA manufacturing

With an NSF grant, Penn Engineering researchers are developing a new manufacturing technique that would be able to produce mRNA sequences in a way that removes the need for cryogenic temperatures.

From Penn Engineering Today

mRNA COVID-19 vaccines induce T-cell responses in multiple sclerosis patients
Person in full PPE administering a vaccine to another person sittting on a hospital bed.

mRNA COVID-19 vaccines induce T-cell responses in multiple sclerosis patients

Research from Penn Medicine shows mRNA COVID-19 vaccines are effective at inducing T-cell responses in multiple sclerosis patients who receive B cell-depleting Infusions even if their antibody responses are diminished.

From Penn Medicine News