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Nanotechnology

Rethinking the computer chip in the age of AI
A computer chip illuminated and elevated with the letters AI printed on it.

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Rethinking the computer chip in the age of AI

A team of researchers from the School of Engineering and Applied Science has introduced a computing architecture ideal for AI using an approach known as compute-in-memory.

From Penn Engineering Today

Inspired by nature, artificial microtubules can work against a current to transport tiny cargoes
graphic of microvascular networks showing how free-swimming microrobots disperse but a microcatheter propels robots against a flow to a target

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hile free-swimming microrobots have been explored as a way to precisely deliver therapeutics within a blood vessel, they can disperse in the strong flows, failing to reach their target at high enough concentrations. In contrast, microrobots propelled along an artificial microtubule, developed by physicist Arnold Mathijssen and colleagues, can be transported precisely, even working against the current. (Image: Courtesy of Arnold Mathijssen/Nature Machine Intelligence)

Inspired by nature, artificial microtubules can work against a current to transport tiny cargoes

Technology developed by Arnold Mathijssen of the School of Arts & Sciences and colleagues could one day clear blockages in blood vessels or precisely target chemotherapy drugs to a tumor.

Katherine Unger Baillie

Making chemical separation more eco-friendly with nanotechnology
Microscopic view of a membrane wall.

Making chemical separation more eco-friendly with nanotechnology

Chemical separation processes are essential to manufacturing, but also consume high levels of energy. Penn Engineers are developing new membranes for energy-efficient membrane-based separations on a nanoscale level.

From Penn Engineering Today

A new class of materials for nanoscale patterning
Three shapes indicating nanomaterial patterns.

The researchers developed a way of alternating between “blocks” of two types of polymer with precise lengths. These “multiblock copolymers” spontaneously form layered and cylindrical structures, which could be used for nanopatterning, a way of manufacturing microscopic components. The researchers also demonstrated a “double gyroid” structure which could be used for more complicated nanopatterning templates. (Image: Penn Engineering Today)

A new class of materials for nanoscale patterning

Recent research demonstrates how a new class of polymers can produce small, precise patterns on the nanometer scale, with future implications for large-scale computer chip fabrication.

Evan Lerner

A new method to increase effectiveness of nanomedicines
Microscopic view of nanomedicine particles attacked by immune system proteins.

Upon injection into the blood, nanomedicines (blue spheres) are immediately attacked by proteins of the immune system called complement proteins (orange). Complement proteins cause rapid destruction of the nanomedicine, and also induce an anaphylaxis-like reaction. By attaching complement-degrading proteins (yellow ninjas made of protein) to the surface of nanomedicines, Penn researchers have largely solved this problem, potentially allowing more diseases to be safely treated by nanomedicine.(Image: Penn Medicine News)

A new method to increase effectiveness of nanomedicines

Penn Medicine researchers have developed a new technique that uses complement inhibitor Factor I to prevent proteins from attacking treatment-carrying nanoparticles so they can better reach targets within the body.

Sophie Kluthe

Penn engineers will develop on-demand, on-site mRNA manufacturing
emulsions of oil and water separated by a layer of nanoparticles.

Bijels, or bicontinuous interfacially jammed emulsion gels, are structured emulsions of oil and water that are kept separated by a layer of nanoparticles. Penn Engineering researchers will develop a way of using them to manufacture mRNA-based therapeutics. (Image: Penn Engineering Today)

Penn engineers will develop on-demand, on-site mRNA manufacturing

With an NSF grant, Penn Engineering researchers are developing a new manufacturing technique that would be able to produce mRNA sequences in a way that removes the need for cryogenic temperatures.

From Penn Engineering Today

New microfluidic device delivers mRNA nanoparticles a hundred times faster
An etched silicon and glass wafer on a surface with a quarter beside it for scale.

The researchers’ new platform technology, called Very Large Scale Microfluidic Integration, allows tens of thousands of microfluidic units to be incorporated into a single three-dimensionally etched silicon-and-glass wafer. (Image: Penn Engineering Today)

New microfluidic device delivers mRNA nanoparticles a hundred times faster

With a “liquid assembly line,” Penn researchers have produced mRNA-delivering-nanoparticles significantly faster than standard microfluidic technologies.

Evan Lerner