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Progress toward a stem cell–based therapy for blindness
Fluorescent microscopy against a black background shows a layer of green flecks over a mix of blue and red labeled cells

Progress toward a stem cell–based therapy for blindness

A multi-institutional effort led by researchers at the School of Veterinary Medicine is taking steps to develop an effective technique to regenerate photoreceptors cells and restore sight in people with vision disorders.

Katherine Unger Baillie

A newly identified stem cell regulator enables lifelong sperm production
Illustration of different cell types that eventually give rise to sperm shows that blocking an early stage of cell development can prevent the formation of sperm

When the enzyme DOT1L is not functional, spermatogonial stem cells become exhausted, leading to a failure of sperm cell development. This crucial role for DOT1L places it in rarefied company as one of just a handful of known stem cell self-renewal factors, a Penn Vet team found. (Image: Courtesy of Jeremy Wang)

A newly identified stem cell regulator enables lifelong sperm production

Research led by Jeremy Wang of the School of Veterinary Medicine has discovered that the enzyme DOT1L, a stem cell renewal factor, is essential for mice to produce sperm throughout their adult lives.

Katherine Unger Baillie

A Penn Vet tale: Olive, the tiny little fighter
A small wide-eyed Shi Tzu holds large boxing gloves in its mouth.

Illustration by Jon Krause.

A Penn Vet tale: Olive, the tiny little fighter

When Olive, the four-month-old Shih Tzu mix, became critically ill with respiratory distress, clinicians at Penn Vet’s Ryan Hospital spent a week collaborating on intensive treatment.

Sacha Adorno

A heart start for Milkshake, the fainting goat
A veterinarian checks a fainting goats heart rate in a vet office.

Laurence Leduc performs an ultrasound on Milkshake during a follow-up appointment. (Image: Penn Vet News)

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A heart start for Milkshake, the fainting goat

When Milkshake’s vitals were dangerously compromised, a team at Penn Vet’s New Bolton Center pinpointed the problem in the fainting goat’s heart, and saved her life.

From Penn Vet

Elucidating the developmental origin of life-sustaining adrenal glands
microscopic image with proteins labeled in red and blue shows tissue that develops into the adrenal glands

The adrenal glands, which pump out crucial hormones, develops differently in mice compared to primates, including humans, according to new research led by the School of Veterinary Medicine. At at early stage of development, the primate adrenogenic coelomic epithelium, which eventually gives rise to the adrenal glands, expresses genes (NR5A1 in red, and GATA1 in blue) in a pattern that diverged with expectations. (Image: Kotaro Sasaki)

Elucidating the developmental origin of life-sustaining adrenal glands

Research led by the School of Veterinary Medicine reveals that adrenal development proceeds differently in humans than it does in mice.

Katherine Unger Baillie

Frozen testicular tissue still viable after 20 years
Cross-section of testes tissue shows a variety of cells labeled pink and blue and sperm

After being transferred to an infertile mouse, testes tissue from a rat that had been frozen for more than two decades gave rise to sperm and germ cells. (Image: Eoin Whelan/PLOS Biology/CC-BY 4.0 https://creativecommons.org/licenses/by/4.0)

Frozen testicular tissue still viable after 20 years

Many pediatric cancer treatments, though lifesaving, can compromise future fertility. In a new study in rodents, researchers from the School of Veterinary Medicine showed that testicular tissue frozen for more than 20 years could give rise to sperm.

Katherine Unger Baillie