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New biomarkers can help target treatment for chronic skin disease
Microscopic view of granulomatous tissue.

Cellular view of granulomatous tissue.

(Image: iStock/Md Saiful Islam Khan)

New biomarkers can help target treatment for chronic skin disease

Researchers at Penn Medicine have found a pathway in certain lymphoid cells that, once targeted, inhibit granulomas from forming in patients with sarcoidosis.

Alex Gardner

Gene therapy trial sees massive improvement in vision
Closeup view of an eyeball with a vision test graphic.

Image: iStock/murat4art

Gene therapy trial sees massive improvement in vision

Patients with a rare disease affecting their sight have experienced quick vision improvements that sustained for the full yearlong Penn Medicine study, with some experiencing a 10,000-fold improvement in their vision.
Weight management drug does not increase risk of depression or suicidal behavior
A person opening the top of a semaglutide prescription pen.

Image: iStock/imyskin

Weight management drug does not increase risk of depression or suicidal behavior

In new clinical trials, researchers from Penn Medicine find that for people without known major psychopathology, taking semaglutide for weight loss are at no increased risk of mental health issues.

From Penn Medicine News

Keeping calm in case of catastrophe
A group of Penn Medicine emergency responders with face masks look over plans during an emergency drill.

Emergency medicine staff get a training over breakfast on how to care for victims of an explosion.

(Image: Courtesy of Penn Medicine News)

Keeping calm in case of catastrophe

How emergency medical teams at Penn Medicine build the playbook for disaster preparedness.

Kelsey Geesler

Understanding the cellular mechanisms driving solid tumors’ robust defense system
A 3D rendering of the tumor microenvironment with cancer cells, T-Cells, nanoparticles, cancer associated fibroblast layer of tumor microenvironment normal cells, molecules, and blood vessels.

In a collaborative interdisciplinary study, Michael Mitchell of the School of Engineering and Applied Science, Wei Guo of the School of Arts & Sciences, and Drew Weissman of the Perelman School of Medicine show that solid tumors can block drug-delivery mechanisms with a “forcefield-like” effect but certain genetic elements that can effectively “shut down” the forcefield. Their findings hint at new targets for delivering cancer treatments that use the body’s immune system to fight tumors.

(Image: iStock / CIPhotos)

Understanding the cellular mechanisms driving solid tumors’ robust defense system

Researchers from Penn have identified a “forcefield-like” defense system in solid tumors and the genetic elements that can switch it off.
A wrap for the first cohort of the Nurse Innovation Fellowship Program
Members of the first cohort of the Nurse Innovation Fellowship Program by Johnson & Johnson in a classroom.

The teams represented geographically diverse institutions from areas across the U.S., from large and small health systems as well as stand-alone hospitals and public health systems in urban and rural locations.

(Image: Courtesy of Penn Nursing News)

A wrap for the first cohort of the Nurse Innovation Fellowship Program

For the past year, 10 teams of two senior nurse leaders from across the country had the opportunity to focus on a problem unique to their health care system through the joint program between Penn Nursing and The Wharton School.

From Penn Nursing News

Doing the work to end health disparities
Ala Stanford.

Ala Stanford is a pediatric surgeon, a professor of practice in the department of biology in the School of Arts & Sciences, with additional appointments as director of community outreach for research activities in the Penn Institute for RNA Innovation, and as a research associate in the Annenberg School for Communication.

(Image: Courtesy of OMNIA)

Doing the work to end health disparities

Ala Stanford is a surgeon, a national leader in health equity, and professor of practice at Penn. Her new book chronicles her path from North Philly, how she served thousands during the COVID-19 pandemic, and her work to end health disparities.

Susan Ahlborn

A new path to dental care for cancer patients
A gloved hand holding up a small tooth x-ray.

Image: iStock/milosljubicic

A new path to dental care for cancer patients

A collaboration between Penn Medicine and Penn’s School of Dental Medicine, pioneered by oncology nurses Margaret “Peg” Rummel and Jen Jacobs, helps cancer patients get the dental care they need in order to be cleared to start radiation.

From Penn Medicine News

Questioning restrictions on physical activity for those at risk of preterm birth
Ellie Mayers and Gladys Smith in front of a sign reading Department of Obstetrics & Gynecology Maternal Fetal Medicine Reproductive Genetics at Penn Medicine.

Two students are conducting research with Beth Leong Pineles of Penn Medicine (not pictured) to study activity restriction for pregnant patients, supported by a Penn Undergraduate Research Mentorship grant. Ellie Mayers (left) is a third-year in the School of Nursing. Gladys Smith (right) is a second-year in the College of Arts and Sciences. 

(Image: Courtesy of Ellie Mayers and Gladys Smith)

Questioning restrictions on physical activity for those at risk of preterm birth

Undergraduates Ellie Mayers and Gladys Smith worked as research assistants this summer gathering data from pregnant patients for a study by Penn Medicine physician Beth Leong Pineles, researching bed rest orders and physical activity restrictions for those at risk of preterm birth.