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Nicotine Withdrawal Weakens Brain Connections Tied to Self-Control Over Cigarette Cravings, Penn Study Finds

Nicotine Withdrawal Weakens Brain Connections Tied to Self-Control Over Cigarette Cravings, Penn Study Finds

People who try to quit smoking often say that kicking the habit makes the voice inside telling them to light up even louder, but why people succumb to those cravings so often has never been fully understood.  Now, a new brain imaging study in this week’s JAMA Psychiatry from scientists in Penn Medicine and the National Institute on Drug Abuse (NIDA) Intramural Research Program sh

Steve Graff

Scientists from Penn and CHOP Confirm Link Between Missing DNA and Birth Defects

Scientists from Penn and CHOP Confirm Link Between Missing DNA and Birth Defects

In 2010, scientists in Italy reported that a woman and her daughter showed a puzzling array of disabilities, including epilepsy and cleft palate. The mother had previously lost a 15-day-old son to respiratory failure, and the research team noted that the mother and daughter were missing a large chunk of DNA on their X chromosome.

Katherine Unger Baillie

Cellular Alchemy: Penn Study Shows How to Make Insulin-Producing Cells from Gut Cells

Cellular Alchemy: Penn Study Shows How to Make Insulin-Producing Cells from Gut Cells

Destruction of insulin-producing beta cells in the pancreas is at the heart of type 1 and type 2 diabetes. “We are looking for ways to make new beta cells for these patients to one day replace daily insulin injections,” says Ben Stanger, MD, PhD, assistant professor of Medicine in the Division of Gastroenterology, Perelman School of Medicine at the University of Pennsylvania.

Karen Kreeger

$3.25 Million Gift Creates Penn Medicine/CHOP Friedreich's Ataxia Center of Excellence

$3.25 Million Gift Creates Penn Medicine/CHOP Friedreich's Ataxia Center of Excellence

Three longtime allies have joined forces to create the new Penn Medicine/CHOP Friedreich’s Ataxia Center of Excellence. The establishment of the center was catalyzed by a $3.25 million gift from the Friedreich’s Ataxia Research Alliance (FARA), in partnership with the Hamilton and Finneran families.

Karen Kreeger

Penn Researchers Model a Key Breaking Point Involved in Traumatic Brain Injury

Penn Researchers Model a Key Breaking Point Involved in Traumatic Brain Injury

Even the mildest form of a traumatic brain injury, better known as a concussion, can deal permanent, irreparable damage. Now, an interdisciplinary team of researchers at the University of Pennsylvania is using mathematical modeling to better understand the mechanisms at play in this kind of injury, with an eye toward protecting the brain from its long-term consequences.

Evan Lerner

Penn Medicine: Personalized Gene Therapy Locks Out HIV, Paving the Way to Control Virus Without Antiretroviral Drugs

Penn Medicine: Personalized Gene Therapy Locks Out HIV, Paving the Way to Control Virus Without Antiretroviral Drugs

University of Pennsylvania researchers have successfully genetically engineered the immune cells of 12 HIV positive patients to resist infection, and decreased the viral loads of some patients taken off antiretroviral drug therapy (ADT) entirely—including one patient whose levels became undetectable.

Steve Graff

Penn Study Results Confirm BMI is a Direct Cause of Type 2 Diabetes and High Blood Pressure

Penn Study Results Confirm BMI is a Direct Cause of Type 2 Diabetes and High Blood Pressure

Using new genetic evidence, an international team of scientists led by experts at the Perelman School of Medicine at the University of Pennsylvania and Children’s Hospital of Philadelphia has found that an increased body mass index (BMI) raised the risk for both type 2 diabetes and higher blood pressure.

Katie Delach

Antonia Villarruel Named Dean of Penn School of Nursing

Antonia Villarruel Named Dean of Penn School of Nursing

Antonia Villarruel has been named dean of the School of Nursing at the University of Pennsylvania, effective July 1. The announcement was made today by Penn President Amy Gutmann and Provost Vincent Price.