Health Sciences

Despite a national consensus among policy makers and educators to train residents to be more conscious of the cost of care, less than 15 percent of internal medicine residency programs have a formal curriculum addressing it, a new research letter published today in JAMA Internal Medicine by a Penn Medicine physician found.

Amyotrophic lateral sclerosis, better known as Lou Gehrig’s disease, is a devastating illness that gradually robs sufferers of muscle strength and eventually causes a lethal, full-body paralysis. The only drug available to treat the disease extends life spans by a meager three months on average.

The Perelman School of Medicine at the University of Pennsylvania will join a new national network of 25 regional stroke centers selected to advance stroke research on prevention, treatment and recovery.

Cancer involves a breakdown of normal cell behavior. Cell reproduction and movement go haywire, causing tumors to grow and spread through the body.

A new study suggests a potential dietary treatment - a cocktail of key amino acids that improved sleep disturbances caused by brain injuries in mice - for millions of people affected by traumatic brain injury (TBI)—a condition that is currently untreatable.

Sleep, or the lack of it, seems to affect just about every aspect of human physiology. Yet, the molecular pathways through which sleep deprivation wreaks its detrimental effects on the body remain poorly understood. Although numerous studies have looked at the consequences of sleep deprivation on the brain, comparatively few have directly tested its effects on peripheral organs. 

The idea of growing replacement tissue to repair an organ, or to swap it out for an entirely new one, is rapidly transitioning from science fiction to fact.

Three and a half years after beginning a clinical trial which demonstrated the first successful and sustained use of genetically engineered T cells to fight leukemia, a research team from the Perelman School of Medicine at the University of Pennsylvania and the Children’s Hospital of Philadelphia will today announce the latest results of studies involving both adults and children with advanced blood cancers that have failed to respond to standard therapies.

A pathway known for its role in regulating adult stem cells has been shown to be important for hair follicle proliferation, but contrary to previous studies, is not required within hair follicle stem cells for their survival, according to researchers with the Perelman School of Medicine at the University of Pennsylvania.

The body is structured to ensure that any invading organisms have a tough time reaching the brain, an organ obviously critical to survival. Known as the blood-brain barrier, cells that line the brain and spinal cord are tightly packed, making it difficult for anything besides very small molecules to cross from the bloodstream into the central nervous system.