Health Sciences

Penn Study Reveals Possible Therapeutic Target for Common, But Mysterious Brain Blood Vessel Disorder

Tens of millions of people around the world have abnormal, leak-prone sproutings of blood vessels in the brain called cerebral cavernous malformations (CCMs). These abnormal growths can lead to seizures, strokes, hemorrhages, and other serious conditions, yet their precise molecular cause has never been determined. Now, cardiovascular scientists at the Perelman School of Medicine at the University of Pennsylvania have studied this pathway in heart development to discover an important set of molecular signals, triggered by CCM-linked gene defects, that potentially could be targeted to treat the disorder.

Karen Kreeger

Penn Study Uncovers Secrets of a Clump-Dissolving Protein

Workhorse molecules called heat-shock proteins contribute to refolding proteins that were once misfolded and clumped, causing such disorders as Parkinson's disease, amyotrophic lateral sclerosis, and Alzheimer's disease. James Shorter, PhD, an associate professor of Biochemistry and Biophysics, at the Perelman School of Medicine at the University of Pennsylvania, has been developing ways to "reprogram" one such protein – a yeast protein called Hsp104 -- to improve its therapeutic properties.

Karen Kreeger

Medicaid "Fee Bump" to Primary Care Doctors Associated with Better Access to Appointments, According to Penn Study

The increase in Medicaid reimbursement for primary care providers, a key provision of the Affordable Care Act (ACA), was associated with a 7.7 percentage points increase in new patient appointment availability without longer wait times, according to results of a new 10-state study — co-authored by researchers at the University of Pennsylvania and the Urban Institute, and funded by the Robert Wood Johnson Foundation — published online-first by the New England Journal of Medicine.

Anna Duerr

Penn Medicine Researchers Discover Possible New General Anesthetics

Penn Medicine researchers, in a continuation of their groundbreaking work to better understand how anesthesia works in the body, have found the first new class of novel anesthetics since the 1970s. Their findings, published in February issue of Anesthesiology, detail the processes through which the group uncovered these compounds.

Lee-Ann Donegan



In the News


Philadelphia Gay News

UPenn hosts free online panel for LGBTQ+ workplace inclusion

The Eidos LGBTQ+ Health Initiative, led by José Bauermeister and Jessica Halem of the School of Nursing, will host a free online panel in April on the integration of LGBTQ+ people in the workforce.

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The New Yorker

How to die in good health

PIK Professor Ezekiel Emanuel says that incessantly preparing for old age mistakes a long life for a worthwhile one.

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Philadelphia Inquirer

Mayor Parker’s plan to ‘remove the presence of drug users’ from Kensington raises new questions

Shoshana Aronowitz of the School of Nursing and Ashish Thakrar of the Perelman School of Medicine comment on the lack of specificity in Philadelphia’s plan to remove drug users from Kensington and on the current state of drug treatment in the city.

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Philadelphia Inquirer

How many patients would recommend their Philly-area hospital to family and friends? Check your local hospital

The Hospital of the University of Pennsylvania has been named one of the most recommended acute-care facilities by patients in the Philadelphia area.

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WHYY (Philadelphia)

Homeward bound: When a Penn Medicine nurse was diagnosed with uterine cancer, she turned to the service dogs she helped to train

A profile highlights Maria Wright of Penn Medicine Lancaster General Health, from her volunteer work connecting people with service dogs to her cancer diagnosis and her own journey applying for a service dog.

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