Health Sciences

The oral cavity is a complex landscape, cavernous and full of irregular structures. Using a two-dimensional X-ray to map its variations can only reveal so much. That’s why a technological revolution that has made three-dimensional imaging of the teeth and jaws easier and safer has ushered in a transformation of practice in the dental clinic.

Two University of Pennsylvania professors are coauthors, along with two other scholars, on a perspective piece published this week in the journal Science that calls for an end to the use of genetic concepts of race in biological research.

Abolishing the 24-hour clock by knocking out a key gene during development accelerates aging and shortens lifespan by two thirds in mice, but this effect is absent if the gene deletion is delayed until after birth, according to a new study published this week in Science Translational Medicine by scientists from the Perelman School of Medicine at the University of Pennsylvania.

For the first time, researchers have shown that an enzyme key to regulating gene expression -- and also an oncogene when mutated -- is critical for the expression of numerous inflammatory compounds that have been implicated in age-related increases in cancer and tissue degeneration, according to new research from the Perelman School of Medicine at the University of Pennsylvania. Inhibitors of the enzyme are being developed as a new anti-cancer target.

A powerful, three-way mechanism by which a mutation drives the growth of childhood brain cancers, was discovered by scientists from the Perelman School of Medicine at the University of Pennsylvania and The Children’s Hospital of Philadelphia (CHOP).

In the ongoing fight against drug addiction, researchers from the University of Pennsylvania’s School of Nursing and Perelman School of Medicine have discovered a unique application for an FDA-approved drug curr

For the first time, researchers have treated an animal model of a genetic disorder using a viral vector to deliver genome-editing components in which the disease- causing mutation has been corrected. Delivery of the vector to newborn mice improved their survival while treatment of adult animals, unexpectedly, made them worse, according to a new study by investigators from the Perelman School of Medicine at the University of Pennsylvania The team published their findings this week in Nature Biotechnology.

In April, one enterprising senior or team of graduates-to-be at the University of Pennsylvania will be named the inaugural President’s Innovation Prize winners. The award comes with $100,000 in seed money and a $50,000 living stipend per team member. And that is just the start.

The Associated Services for the Blind and Visually Impaired will recognize the University of Pennsylvania’s Gustavo D.

A powerful new machine-learning technique can be applied to large datasets in the biological sciences to uncover previously unknown features of organisms and their genes, according to a team led by researchers from the Perelman School of Medicine at the University of Pennsylvania. For ex