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"Gene Fusion" Mutation Uses Three-Way Mechanism To Drive Childhood Brain Cancers

"Gene Fusion" Mutation Uses Three-Way Mechanism To Drive Childhood Brain Cancers

A powerful, three-way mechanism by which a mutation drives the growth of childhood brain cancers, was discovered by scientists from the Perelman School of Medicine at the University of Pennsylvania and The Children’s Hospital of Philadelphia (CHOP).

Karen Kreeger

Penn Researchers Offer New Approach to Treating Cocaine Addiction

Penn Researchers Offer New Approach to Treating Cocaine Addiction

In the ongoing fight against drug addiction, researchers from the University of Pennsylvania’s School of Nursing and Perelman School of Medicine have discovered a unique application for an FDA-approved drug curr

Michele W. Berger

Viral Gene Editing System Corrects Genetic Liver Disease in Newborn Mice

Viral Gene Editing System Corrects Genetic Liver Disease in Newborn Mice

For the first time, researchers have treated an animal model of a genetic disorder using a viral vector to deliver genome-editing components in which the disease- causing mutation has been corrected. Delivery of the vector to newborn mice improved their survival while treatment of adult animals, unexpectedly, made them worse, according to a new study by investigators from the Perelman School of Medicine at the University of Pennsylvania The team published their findings this week in Nature Biotechnology.

Karen Kreeger

Powerful Machine-Learning Technique Uncovers Unknown Features of Important Bacterial Pathogen, According to Penn Study

Powerful Machine-Learning Technique Uncovers Unknown Features of Important Bacterial Pathogen, According to Penn Study

A powerful new machine-learning technique can be applied to large datasets in the biological sciences to uncover previously unknown features of organisms and their genes, according to a team led by researchers from the Perelman School of Medicine at the University of Pennsylvania. For ex

Karen Kreeger

Penn-Engineered Neural Networks Show Hope for Axonal Repair in the Brain, with Minimal Disruption to Brain Tissue

Penn-Engineered Neural Networks Show Hope for Axonal Repair in the Brain, with Minimal Disruption to Brain Tissue

Lab-grown neural networks have the ability to replace lost axonal tracks in the brains of patients with severe head injuries, strokes or neurodegenerative diseases and can be safely delivered with minimal disruption to brain tissue, according to new research from Penn Medicine’s department of Neurosurgical Research.

Lee-Ann Donegan

Penn Study Suggests New Recommendations to Reduce Radiation Risk from Digital Screening Mammography

Penn Study Suggests New Recommendations to Reduce Radiation Risk from Digital Screening Mammography

Radiation-induced breast cancer risk from digital mammography is low for the majority of women, but risk is higher in women with large breasts, who received 2.3 times more radiation and required more views per examination to image as much of the breast as possible compared to those with small or average-sized breasts.

Greg Richter