The London-based LouLou Foundation and the Orphan Disease Center of the Perelman School of Medicine have established a Program of Excellence to develop effective treatments for children with CDKL5, a rare X-chromosome-linked genetic disorder that causes severe neuro-developmental impairment and early-onset, difficult-to-control seizures.
The LouLou Foundation will provide a three-year, renewable umbrella grant to fund all aspects of the program in order to help identify and fill gaps in basic research needed to develop medications and treatments for the disease, promote collaboration among CDKL5 investigators at leading other institutions, and engage with the biopharma industry.
“We are extremely grateful to LouLou Foundation for this grant,” says James M. Wilson, director of the Orphan Disease Center and a professor at Penn Medicine. “The marketplace provides few incentives for private-sector support of urgently needed research for orphan diseases such as CDKL5.”
OpenAI, DeepSeek, and Google vary widely in identifying hate speech
Neil Fasching and Yphtach Lelkes of the Annenberg School for Communication have found dramatic differences in how large language models classify hate speech, with especially large variations for language about certain demographic groups, raising concerns about bias and disproportionate harm.
Understanding order to disorder at the atomic scale opens possibilities for next-generation electronic devices
A Penn team has developed insight into the chemical and geometric mechanisms underlying the synthesis of new 2D materials, paving the way for next-gen devices, biomedical applications, and cleaner, quicker energy conversion and storage.
(From left) Kevin B. Mahoney, chief executive officer of the University of Pennsylvania Health System; Penn President J. Larry Jameson; Jonathan A. Epstein, dean of the Perelman School of Medicine (PSOM); and E. Michael Ostap, senior vice dean and chief scientific officer at PSOM, at the ribbon cutting at 3600 Civic Center Boulevard.
Reimagined Penn Medicine facility set to usher in a bold new era of Immune Health discovery
3600 Civic Center Boulevard will bring together key researchers and technologies in Immune Health, the Colton Center for Autoimmunity, and infectious diseases to drive breakthrough science.
