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Biology
Side Gigs for Good
After putting in a full, impactful day at work at Penn, some faculty and staff fill their spare hours with endeavors that make a difference.
These overlooked global diseases take a turn under the microscope
Faculty at the School of Veterinary Medicine target neglected tropical diseases with advanced science, cross-disciplinary collaborations, and work in the lab and the field.
Computer-generated antibiotics and biosensor Band-Aids
For Penn synthetic biologist César de la Fuente and his team, these concepts aren’t some far-off ideal. They’re projects already in progress, and they have huge real-world implications should they succeed.
Where math meets biology
Through his research, Yoichiro Mori, the Calabi-Simons Visiting Professor of Mathematics and Biology, demonstrates how mathematical theories can provide insights into complex, living systems.
Reprogramming ant ‘soldiers’
A Penn study reveals the epigenetic pathway that controls social behavior in carpenter ants, finding that the ants reprogram up to five days after they hatch, while reprogramming was ineffective at the 10-day mark.
Consuming alcohol leads to epigenetic changes in brain memory centers
What drives the biology behind alcohol cravings has remained largely unknown. A new Penn study shows how a byproduct of the alcohol breakdown produced mostly in the liver travels to the brain’s learning system and impacts behavior around environmental cues to drink.
The science of sensations
To confront the ills of the opioid epidemic, scientists must develop a fundamental understanding of the biology of pain. Biologist Ishmail Abdus-Saboor’s work is setting the stage for screening alternative drugs and uncovering new pathways that an opioid-alternative could target.
Engineers solve the paradox of why tissue gets stiffer when compressed
Tissue gets stiffer when it’s compressed. That stiffening response is a long-standing biomedical paradox, as common sense dictates that when you push the ends of a string together, it loosens tension, rather than increasing it. New research explains the mechanical interplay between that fiber network and the cells it contains.
Fruit flies’ microbiomes shape their evolution
In just five generations, an altered microbiome can lead to genome-wide evolution in fruit flies, according to new research led by Paul Schmidt and postdoc Seth Rudman of the School of Arts and Sciences.
A molecular ‘atlas’ of animal development
Scientists have studied the nematode worm Caenorhabditis elegans for decades, making essential contributions to basic science. In the latest milestone, a team uses cutting-edge technology to individually profile the genes expressed in more than 80,000 cells in a developing C. elegans embryo.
In the News
Bird flu virus has been spreading in U.S. cows for months, RNA reveals
Louise Moncla of the Veterinary School of Medicine says that the bird flu virus is clearly being transmitted to cows in some way.
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Man does DNA test, not prepared for what comes back ‘unusually high’
César de la Fuente of the School of Engineering and Applied Science and Perelman School of Medicine says that Neanderthal DNA provides insights into human evolution, population dynamics, and genetic adaptations, including correlations with traits such as immunity and susceptibility to diseases.
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When is the best time to take L-theanine—morning or night?
According to Colleen Tewksbury of the School of Nursing, research suggests that L-theanine may help support stress management, sleep, and potentially weight management.
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Is the flu shot market a slam dunk for mRNA vaccines? Experts aren’t so sure
Scott Hensley of the Perelman School of Medicine is working on a flu vaccine to provide protection against 20 subtypes of flu that may pose a pandemic threat in the future.
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Thanks, Neanderthals: How our ancient relatives could help find new antibiotics
A study by César de la Fuente of the Perelman School of Medicine and colleagues used AI to recreate molecules from ancient humans that could be potential candidates for antimicrobial treatments.
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Long COVID brain fog may originate in a surprising place, say scientists
A study by Christoph Thaiss and Maayan Levy of the Perelman School of Medicine and colleagues finds that long COVID’s neurological symptoms, like brain fog, memory loss, and fatigue, may stem from serotonin reduction.
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