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A new study finds genome refolding contributes to resistance to cancer therapy
Two cartoon hands holding lines of yarn, twisted into genetic shapes.

If you stretched the DNA fiber packed inside of a single cell, it would reach six feet long from end to end—that’s like fitting a ball of yarn twice the size of Manhattan into a tennis ball. Penn researchers have discovered that the misfolding of DNA can reposition transcription factors and lead to cancer drug resistance. (Image: Penn Medicine News)

A new study finds genome refolding contributes to resistance to cancer therapy

While gene mutations can lead to drug resistance, researchers in the Perelman School of Medicine have identified an important, non-genetic adaptation that could also drive resistance to targeted therapy in T cell leukemia, a type of blood cell cancer.

Lauren Ingeno

Why unions matter for nursing
A nurse seated at a work station in a large hospital room with patient beds.

Image: Amir Arabshahi on Unsplash

Why unions matter for nursing

A new study examines nursing’s relationship to union organizing and feminism, as well as the profession’s unique organizing challenges.

Alina Ladyzhensky

How a class of ‘brilliant graduates’ shaped modern Chinese architecture
chinese drawing architecture

(Homepage image) A protestant church designed by Tung Chuin in 1928 and awarded the Beaux Arts Institute of Design 1st place medal. This rendering and the works of more than 20 architecture student alumni from China are currently on display as part of the “Building in China” exhibition. (Image: Ming Tong)

How a class of ‘brilliant graduates’ shaped modern Chinese architecture

The ‘Building in China’ exhibition showcases the work of the ‘first generation’ of Penn architecture alumni from China and how striking a balance between modern and traditional continues to shape the country’s expression of its national identity.

Erica K. Brockmeier

Social isolation and anxiety in older adults with cognitive impairment
Elderly person sitting alone wearing a face mask.

Social isolation and anxiety in older adults with cognitive impairment

Social isolation among older adults with cognitive impairment has been historically understudied. Since the pandemic, older adults, particularly those with cognitive impairment, may be particularly vulnerable to ill effects from social isolation.

Diversion programs reduce criminal justice system footprint
A wooden elevated path in the woods with two choices for directions to take.

Diversion programs reduce criminal justice system footprint

Research from Penn criminologists and the Philadelphia District Attorney’s Office found that such programs increase expungement rates and lower reconviction rates, leading to a net-narrowing effect overall.

Michele W. Berger

Unlocking the potential of ‘smart’ water in responding to climate change
Aerial view of a flooded Texas town.

Columbus, Texas, was one small town that experienced devastating floods from Hurricane Harvey in 2017. Allison Lassiter’s research focuses on coastal communities from New Jersey to Texas. (Image: Weitzman News)

Unlocking the potential of ‘smart’ water in responding to climate change

Assistant Professor of City and Regional Planning Allison Lassiter researches unlocking the potential of ‘smart’ water in responding to climate change.

From the Weitzman School of Design

Through the metaverse, and what can be found there
Computer generated image of person with virtual reality headset on.

Through the metaverse, and what can be found there

The Wharton School’s Sarah Hammer sheds light on how the metaverse may impact education, health care, diversity initiatives—and may even help people reduce their reduce carbon footprint.

Dee Patel

Cyberattacks, Russia, and the changing face of war in the 21st century
On the screen of a tablet (l), the website of the Russian TV channel RT can be seen. On the right, the screen of a smartphone shows the official Twitter account of Ukrainian President Selenskyj

Penn Today spoke with Heli Tiirmaa-Klaar, a Perry World House visiting fellow, to learn more about how cyberattacks have shaped modern warfare and how countries are adapting their cyber defense strategies amidst the ongoing war. (Image: Fernando Gutierrez-Juarez/picture-alliance/dpa/AP images)

Cyberattacks, Russia, and the changing face of war in the 21st century

Heli Tiirmaa-Klaar, a visiting fellow of Perry World House, shares her expertise in cybersecurity and how cyber methods are being utilized during the Russian invasion of Ukraine.

Erica K. Brockmeier