Molecules Work the Day Shift to Protect the Liver from Accumulating Fat, Says Penn Study
The liver normally makes and stores fat, which is required in moderation for normal body function. However, if the process goes awry, excess fat in the liver can cause major liver damage. In fact, fatty liver is a leading cause of liver failure in the United States, and is often brought on by obesity and diabetes. In turn, the increasing prevalence of these diseases has brought with it an epidemic of liver disease.
Abnormal sleep patterns, such as those of shift-workers, can be risk factors for obesity and diabetes. Investigators have known for decades that fat production by the liver runs on a 24-hour cycle, the circadian rhythm, and is similar to the sleep-wake cycle. A research team led by Mitchell Lazar, MD, PhD, director of the Institute for Diabetes, Obesity, and Metabolism at the University of Pennsylvania School of Medicine, has discovered molecules that act as “shift workers” to maintain the daily rhythm of fat metabolism. When those molecules do not do their jobs, the liver dramatically fills with fat. These findings are reported in this week’s issue of Science.
Materials in the Annenberg School for Communication Library Archives include thousands of TV scripts, the first issue of TV Guide, and interviews about the early days of HBO—which help to chronicle TV’s 100-year story.
Centering joy in AI development and implementation
PIK Professor Desmond Upton Patton—of Annenberg and SP2—and collaborators introduce a joy-informed framework designed to initiate conversations among engineers, designers, and researchers.
Winter Storm Fern brought icy and snowy conditions to the Northeast and other parts of the country over the weekend. Penn Today asks physicist Robert Carpick about the unique properties of ice, the science of curling, and how close we are to ‘nonslip’ ice.
Organizations like Penn’s Netter Center for Community Partnerships foster collaborations between Penn and public schools in the West Philadelphia community.
Penn receives national distinction for community engagement
The recognition by the American Council on Education and Carnegie Foundation for the Advancement of Teaching acknowledges Penn’s long-standing commitment to community-engaged scholarship and partnerships in West Philadelphia and beyond.
