A new therapeutic agent tested in a mouse model of multiple sclerosis (MS) produced anti-inflammatory activity and prevented loss of cells in the optic nerve, according to a new study by researchers in the Perelman School of Medicine at the University of Pennsylvania, with Pittsburgh-based Noveome Biotherapeutics.

In cells, DNA is transcribed into RNAs that provide the molecular recipe for cells to make proteins. Most of the genome is transcribed into RNA, but only a small proportion of RNAs are actually from the protein-coding regions of the genome.

Patients who had a diagnosis of Parkinson’s disease (PD) with dementia (PDD) or dementia with Lewy bodies (DLB) and had higher levels  of Alzheimer’s disease (AD) pathology in their donated post-mortem brains also had more severe symptoms of these Lewy body diseases (LBD) during their lives, compared to those whose brains had less AD pathology, according to research from the 

The value of intersecting the sequencing of individuals’ exomes (all expressed genes) or full genomes to find rare genetic variants -- on a large scale -- with their detailed electronic health record (EHR) information has “myriad benefits, including the illumination of basic human biology, the early identification of preventable and treatable illnesses, and the identification and validation of

Yvonne J. Paterson, PhD, a professor of Microbiology in the Perelman School of Medicine at the University of Pennsylvania, has been elected a fellow of the National Academy of Inventors. Fellows are named inventors on U.S.

Ten professors from the University of Pennsylvania have been named Fellows of the American Association for the Advancement of Science. They are among a class of 391 members honored for their scientifically or socially distinguished efforts to advance science or its applications.

Penn Medicine researchers, along with colleagues at Cincinnati Children's Hospital and Boston University, have received a $5.2 million, seven-year grant from the National Heart, Lung, and Blood Institute of the National Institutes of Health (NIH) to study the cellular and molecular mechanisms that promote lung regeneration.

The National Science Foundation (NSF) has awarded the University of Pennsylvania a $24 Million, five-year grant to establish a Science and Technology Center (STC) focused on engineering mechanobiology, or the way cells exert and are influenced by the physical forces in their environment. This award is part of an overall $94 million from NSF to support four new STCs.

A high-fat-diet-induced immune reaction causes inflammation leading to intestinal cancer in a mouse model – even among animals that are not obese -- according to a new study from thePerelman School of Medicine at the University of Pennsylvania, Case Western Reser

A study of a new mouse model identifies a drug target that has the potential to increase social interaction in individuals with some forms of autism spectrum disorder (ASD), according to researchers in the Perelman School of Medicine at the University of Pennsylvania.