As the population ages, cases of age-related macular degeneration are forecast to skyrocket. New research led by a team from Penn may help make inroads into understanding its roots and possible therapies.
Modeling the most common form of vision loss in older adults
Age-related macular degeneration is the leading cause of vision loss in people older than 50. Kathleen Boesze-Battaglia and colleagues have developed a model system that mimics many features of the human condition, giving scientists a platform to gain a deeper understanding of risk factors and possible treatments.
Researchers from Penn and Technical University of Dresden found that the protein Del-1 takes on different functions depending on the cell that secretes it. When secreted by the immune system's macrophages, it acts as a bridge between those cells and neutrophils to help clear inflammation. (Image: Courtesy of George Hajishengallis)
To resolve inflammation, location matters
A single protein can both restrain the initiation of inflammation and help to actively resolve it, according to new research led by George Hajishengallis of the School of Dental Medicine. He and his colleague found that the type of cell that secretes the protein determines which activity the protein promotes.
The changing foliage of Penn’s trees make even a gray and rainy day look bright. Campus staff take a proactive approach to maintaining the trees’ health.
Keeping campus trees—all 6,800 of them—healthy and vibrant
Caring for the trees on Penn’s campus—an official arboretum since last year—is no small undertaking. Staff from Facilities and Real Estate Services and the Morris Arboretum lead the way in ensuring that the University’s trees remain safe, vibrant, diverse, and beautiful.
Rui Jing Jiang and Brandon Kao, winners of the 2018 President’s Innovation Prize, are well on their way to their goal: to gain FDA approval for a device to treat glaucoma.
Biochemical and paleoclimate modeling revealed that plants with a new photosynthetic pathway known as C4, present in several important crop species today, emerged when atmospheric carbon dioxide was still quite high, roughly 30 million years ago. Water limitations, rather than Co2, drove its initial spread, a Penn-led team found.
Dry conditions may have helped a new type of plant gain a foothold on Earth
Plants reap energy from the sun using two photosynthesis pathways, C3 and C4. A new study led by Haoran Zhou, Erol Akçay and Brent Helliker suggests that water availability drove the expansion of C4 species, which may help to explain how different plant lineages came to be distributed on the planet today.
Staying alert to the rare but real risks of acute flaccid myelitis
Sarah Hopkins, a pediatric neurologist at the Perelman School of Medicine and Children’s Hospital of Philadelphia, has seen an increase in cases of the paralyzing condition this year. She explains what parents and pediatricians should watch for.
Melissa Hopkins stands ready with a treat as her dog Cedar successfully locates a target scent during a class at Penn Vet’s Working Dog Center. One of the course’s instructors, Meghan Ramos (at left in blue), says the course allows owners to “help their dog contribute to society in a positive way.”
Sniffing for science
In the “Citizen Science” course at the School of Veterinary Medicine’s Working Dog Center, Meghan Ramos and Tessa Seales work with dog owners to enhance their pups’ scent detection skills, with an eye toward bolstering the Center’s research.
Over his career as a science journalist, Carl Zimmer has seen legitimate science reporting denied and illegitimate science news taken as fact. In advance of a talk at Penn, Zimmer discusses the problem of misinformation and offers tips for avoiding being fooled by bogus science stories.
Irrigated crops can grow with less water but are typically subject to increased salts leached out of the surrounding soil, which can put a dent in productivity. A new study led by Penn biologists has uncovered a way plants respond to salt stress—a pathway that could be manipulated to engineer more tolerant crops.
How plants cope with stress
With climate change comes drought, and with drought comes higher salt concentrations in the soil. Brian Gregory and graduate student Stephen Anderson have identified a mechanism by which plants respond to salt stress, a pathway that could be targeted to engineer more adaptable crops.
Gathered in Fagin Hall for a daylong disease outbreak symposium, students worked across disciplines to devise strategies for containing a fictionalized infection. Laurel Redding, a School of Veterinary Medicine faculty member and event facilitator, writes up her group’s thoughts during a brainstorming session.
Staging the plague
Eighty-one students training in a diversity of health professions worked with regional and federal agencies to confront an imagined outbreak scenario centered around bubonic plague in Philadelphia.
