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Lipid nanoparticles present one of the most advanced drug delivery platforms to shuttle promising therapeutics such as mRNA but are limited by the time it takes to synthesize cationic lipids, a key component. Now, Michael Mitchell and his team at the School of Engineering and Applied Science have developed a faster way to make cationic lipids that are also more versatile, able to carry different kinds of treatments to target specific organs.
(Image: iStock / Dr_Microbe)
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iStock: microgen
(Image: dusanpetkovic)
For more than 17 years, PIK Professor Michael Platt and his collaborators have followed a free-ranging colony of rhesus macaques in the Puerto Rican Island of Cayo Santiago who, in 2017, experienced the devastation of Hurricane Maria. The team showed that the macaques who invested in relationships had higher survival rates, findings that can provide insights into human social behavior and health in the face of environmental change.
(Image: Courtesy of Lauren J. Brent)
(Image: Courtesy of Kotaro Sasaki)
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This image visualizes the Milky Way and its surrounding “halo” of stars. Most stars in the Milky Way lie in the disc (like the Sun, for example), but stars from past collisions end up in the halo, a large “cloud” of stars that extends outwards in all directions. These halo stars have been enhanced in this image, but in reality would be very dim compared to the disc. The halo appears messy and “wrinkly” here, a sign that a merger has occurred relatively recently.
(Image: Halo stars: ESA/Gaia/DPAC, T Donlon et al. 2024; Background Milky Way and Magellanic Clouds: Stefan Payne-Wardenaar)
China Byrns used high-magnification confocal microscopy to visualize senescent glia (red) in Drosophila brains as part of a multidisciplinary approach to define the origin and effects of senescent cells in brain aging.
(Image: Courtesy of Riya Anand)