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The virtual assistant
hand holding a tablet

The virtual assistant

Artificial intelligence has permeated many corners of life, from consumer purchasing and media consumption to health care—sometimes in ways we don’t even know.

Michele W. Berger

Reproductive science by experts, for teens
high school students in lab coats face an instructor in a reproductive science lab.

Reproductive science by experts, for teens

High school girls who take part in the Penn Academy for Reproductive Science get a hands-on lab course with top epigenetic and reproductive health experts.
CAR T cell therapy may be harnessed to treat heart disease
Rendering of tumors surrounding heart

CAR T cell therapy may be harnessed to treat heart disease

Penn Med researchers used genetically modified T cells to improve heart function in an animal model after cardiac injury, a step forward in expanding the use of the technology to treating, or even reversing, heart failure.

Penn Today Staff

Is treatment forever? Success of gene therapy for inherited blindness depends on timing
Top-and-bottom show fluorescent, microscopic images of layers of the eye's retina in blue, green, and red.

Canine retinas after successful gene augmentation therapy with RPE65 (red-labeling of the RPE cell layer). When eyes are treated at a stage when photoreceptor numbers are close to normal, there is an arrest of retinal degeneration, and cone (labeled in green) and rod photoreceptors retain normal structure for at least four years following treatment (upper image). If degeneration is ongoing at the time of treatment, there is substantial and progressive loss of photoreceptors in spite of robust RPE65 expression (lower image). (Image: Aguirre Laboratory/Penn Vet)

Is treatment forever? Success of gene therapy for inherited blindness depends on timing

An FDA-approved gene therapy for Leber congenital amaurosis, an inherited vision disorder with a childhood onset and progressive nature, has improved patients’ sight. But new research underscores the importance of further investigation to halt the progression of the disorder.

Katherine Unger Baillie

A molecular ‘atlas’ of animal development
An abstract depiction of data features an elongated shape with various projections in pixels of different colors.

Each cell of a developing nematode worm embryo is catalogued at the molecular level in a new paper out in Science. In this visualization of the dataset, each dot represents a single cell, its color represents the age of the embryo it came from (orange=early, green=mid, blue/red=late), and the dots are arranged so that cells with similar transcriptomes are near each other. Visualized this way, the data form various thin “trajectories” that correspond to tissues and individual cell types. (Image: Cole Trapnell)

A molecular ‘atlas’ of animal development

Scientists have studied the nematode worm Caenorhabditis elegans for decades, making essential contributions to basic science. In the latest milestone, a team uses cutting-edge technology to individually profile the genes expressed in more than 80,000 cells in a developing C. elegans embryo.

Katherine Unger Baillie

Researcher Virginia M.Y. Lee receives $3 million Breakthrough Prize
Virginia M. Y. Lee in her lab wearing a lab coat.

Virginia M. Y. Lee

Researcher Virginia M.Y. Lee receives $3 million Breakthrough Prize

The Breakthrough Prize award recognizes Lee’s work studying underlying mechanisms of neurodegenerative diseases like Alzheimer’s disease, Parkinson’s disease, and other dementias.

Penn Today Staff

A potential new treatment for a deadly form of prostate cancer
3-d illustration of cancer cells

A potential new treatment for a deadly form of prostate cancer

Blocking a specific protein sets off a chain reaction that results in the death of prostate cancer cells that have spread and are resistant to standard therapies.

Penn Today Staff