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Cell development discovery changes our understanding of how genes shape early embryos
side-by-side comparison of two nuclei with different compaction

Blotchy black regions of a nucleus (left), with normal chromatin compaction (denoted by black spots). Nucleus deficient in the enzymes (right). (Photo credit: Dario Nicetto)

Cell development discovery changes our understanding of how genes shape early embryos

To fit inside each nucleus, DNA coils around specialized proteins. These spools of wrapped DNA inhibit gene regulatory proteins from binding to protein-coding stretches along the genome, which help keep genes in the “off” position when they’re not needed.

Penn Today Staff

Resistance to cancer treatment is a chain reaction
raised surface of melanoma amidst microscopic skin cells

Skin tissue cancer cells

Resistance to cancer treatment is a chain reaction

A study identifies a chain reaction in cells that enables cancer to resist treatments that target BRAF mutations.

Penn Today Staff

Doctors can weigh in on brain tumors remotely
 Stock image of brain scan

Doctors can weigh in on brain tumors remotely

Brain tumor patients will now have access to Penn Medicine’s cancer expertise through the new telemedicine second opinion program for brain tumors.

Penn Today Staff

The road to more hand transplants
 Stock image of holding hands

The road to more hand transplants

Over the past 20 years, more than 85 amputees around the world have received a hand or bilateral hand transplant—including two adults and one child at Penn Medicine and Children’s Hospital of Philadelphia.

Penn Today Staff

Boots on the ground for the opioid task force
pill sorting at pharmacy

Boots on the ground for the opioid task force

Opioid addiction is a “public health emergency,” according to the Department of Health and Human Services. Overdose deaths involving opioids—both prescription and illegal—have increased fivefold between 1999 and 2016.

Penn Today Staff

Telemedicine today, and the future of virtual health care
A computer and smartphone with a blood pressure cuff A smartphone, blood pressure cuff, and computer interface demonstrating the Heart Safe Motherhood interface. (Photo courtesy: Adi Hirshberg)

Telemedicine today, and the future of virtual health care

From the Connected Care Center central hub for ICU patients, to telegenetics, Penn practitioners are looking to the future of convenient care.
Personalized gene editing is a family affair
  anatomically-accurate heart superimposed over graphic waves

Personalized gene editing is a family affair

A new stem cell-based test aims to decrease the uncertainty of gene variants and their affect on a patient’s health.

Penn Today Staff

Injection improves vision in a form of childhood blindness
young child covering one eye with a hand with eye chart letters on the right side

Injection improves vision in a form of childhood blindness

A new treatment for patients with a form of congenital retinal blindness has shown success in improving vision, according to results published today in Nature Medicine led by researchers at the Scheie Eye Institute in the Perelman School of Medicine

Penn Today Staff

Thoughts from a medical ethicist on gene editing babies
Gloved hand taking scissors to a strand of DNA.

Since it started making headlines five years ago, the gene-editing technology CRISPR has been controversial. It’s back in the news after a researcher in China claims to have altered the DNA of twin girls. 

Thoughts from a medical ethicist on gene editing babies

In a Q&A, PIK Professor Jonathan Moreno discusses using CRISPR technology on humans and the future of the field.

Michele W. Berger

Podcast series charts a path for Latin Americans in science
With a microphone between them, Enrique Lin-Shiao and Kevin Alicea-Torres sit for an interview with one of the subjects of their podcast.

Co-founders of the "Caminos en Ciencia" podcast, biomedicine doctoral students Enrique Lin-Shiao and Kevin Alicea-Torres craft their program to highlight the career tracks and accomplishments of Latinx scientists. (Photo: Courtesy of Lin-Shiao and Alicea-Torres)

Podcast series charts a path for Latin Americans in science

Concerned about the scarcity of Latin Americans in scientific careers, doctoral students Kevin Alicea-Torres and Enrique Lin-Shiao took action to prime the pump. On their Spanish-language podcast, “Caminos en Ciencia,” they chat with Latinx scientists who discuss their career paths and provide advice for young scientists-to-be.

Katherine Unger Baillie