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Penn mourns the loss of Raymond G. Perelman
Ray Perelman

Raymond G. Perelman

Penn mourns the loss of Raymond G. Perelman

The University of Pennsylvania is mourning the death of Raymond G. Perelman, one of its most significant and committed partners.

Penn Today Staff

Hindering melanoma metastasis with an FDA-approved drug
Two square panels, the left labeled "vehicle" and the right labeled "resperine." The vehicle panel has both blue and green dots and markings throughout, while the resperine panel has only blue markings.

In a mouse model, the FDA-approved drug reserpine seemed to hamper the ability of tumors to reshape distant tissues in ways that would encourage metastasis, for example, reducing the accumulation of fibronectin, a protein associated with certain types of cancer.

Hindering melanoma metastasis with an FDA-approved drug

A drug approved by the FDA 65 years ago for blood pressure control may aid in preventing cancer from spreading to distant organs. New research led by Serge Fuchs revealed that this drug disrupted formation of a fertile environment for metastasis by protecting healthy cells from harmful vesicles released by tumors.

Katherine Unger Baillie

Can music improve anxiety and depression for people with memory disorders?
Two women and a man playing large bongo drums.

Mary Javian, chair of career studies at the Curtis Institute, Tempy Small, a program participant, and Adam Pangburn, coordinator of community performance at Curtis, participated in a drum circle to close out the final “Creative Expression through Music” session. Nick DiBerardino (not pictured) lead the classes, which were coordinated by Penn graduate students Sarah Bujno and Matt Volpe (in the background).

Can music improve anxiety and depression for people with memory disorders?

That’s the aim of a recently completed pilot program connecting Penn Memory Center patients, Penn graduate students, and Curtis Institute musicians.

Michele W. Berger

Does opioid use in pets create higher risk for abuse in humans?
Labrador puppy on exam table with vet in background

Weapons-grade cuteness.

nocred

Does opioid use in pets create higher risk for abuse in humans?

A new study shows a 41 percent increase in opioids for small animals over the past 10 years, indicating an avenue of potential risk for human access to opioids.

Penn Today Staff

Cell development discovery changes our understanding of how genes shape early embryos
side-by-side comparison of two nuclei with different compaction

Blotchy black regions of a nucleus (left), with normal chromatin compaction (denoted by black spots). Nucleus deficient in the enzymes (right). (Photo credit: Dario Nicetto)

Cell development discovery changes our understanding of how genes shape early embryos

To fit inside each nucleus, DNA coils around specialized proteins. These spools of wrapped DNA inhibit gene regulatory proteins from binding to protein-coding stretches along the genome, which help keep genes in the “off” position when they’re not needed.

Penn Today Staff

Resistance to cancer treatment is a chain reaction
raised surface of melanoma amidst microscopic skin cells

Skin tissue cancer cells

Resistance to cancer treatment is a chain reaction

A study identifies a chain reaction in cells that enables cancer to resist treatments that target BRAF mutations.

Penn Today Staff

Doctors can weigh in on brain tumors remotely
 Stock image of brain scan

Doctors can weigh in on brain tumors remotely

Brain tumor patients will now have access to Penn Medicine’s cancer expertise through the new telemedicine second opinion program for brain tumors.

Penn Today Staff

The road to more hand transplants
 Stock image of holding hands

The road to more hand transplants

Over the past 20 years, more than 85 amputees around the world have received a hand or bilateral hand transplant—including two adults and one child at Penn Medicine and Children’s Hospital of Philadelphia.

Penn Today Staff

Boots on the ground for the opioid task force
pill sorting at pharmacy

Boots on the ground for the opioid task force

Opioid addiction is a “public health emergency,” according to the Department of Health and Human Services. Overdose deaths involving opioids—both prescription and illegal—have increased fivefold between 1999 and 2016.

Penn Today Staff

Telemedicine today, and the future of virtual health care
A computer and smartphone with a blood pressure cuff A smartphone, blood pressure cuff, and computer interface demonstrating the Heart Safe Motherhood interface. (Photo courtesy: Adi Hirshberg)

Telemedicine today, and the future of virtual health care

From the Connected Care Center central hub for ICU patients, to telegenetics, Penn practitioners are looking to the future of convenient care.