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Understanding the cellular mechanisms driving solid tumors’ robust defense system
A 3D rendering of the tumor microenvironment with cancer cells, T-Cells, nanoparticles, cancer associated fibroblast layer of tumor microenvironment normal cells, molecules, and blood vessels.

In a collaborative interdisciplinary study, Michael Mitchell of the School of Engineering and Applied Science, Wei Guo of the School of Arts & Sciences, and Drew Weissman of the Perelman School of Medicine show that solid tumors can block drug-delivery mechanisms with a “forcefield-like” effect but certain genetic elements that can effectively “shut down” the forcefield. Their findings hint at new targets for delivering cancer treatments that use the body’s immune system to fight tumors.

(Image: iStock / CIPhotos)

Understanding the cellular mechanisms driving solid tumors’ robust defense system

Researchers from Penn have identified a “forcefield-like” defense system in solid tumors and the genetic elements that can switch it off.
Uncovering new antibiotics inside the human gut
Microscopic rendering of bacterial in the small intestines.

Image: iStock/ChrisChrisW

Uncovering new antibiotics inside the human gut

Researchers from Penn Engineering, led by César de la Fuente, have leveraged AI to discover dozens of potential new antibiotics in the human gut microbiome.

Ian Scheffler

Penn Medicine, 76ers restore community basketball court
Members of the Penn Medicine community play basketball with kids at the Roberto Clemente Park.

The updated Roberto Clemente Park in Fairmount now boasts a freshly repaved court complete with new backboards and nets.

(Image: Courtesy of Penn Medicine News)

Penn Medicine, 76ers restore community basketball court

The latest product of the partnership between two iconic Philadelphia institutions, a newly refurbished court at Roberto Clemente Park will support healthy behavior in the community.

From Penn Medicine News

A modified peptide shows promise for fighting tumors
Tumor microenvironment.

A collaborative team of researchers including scientists from the School of Veterinary Medicine and Perelman School of Medicine show how a modified peptide can successfully target the immunosuppressive tumor microenvironment.

(Image: iStock/Marcin Klapczynski)

A modified peptide shows promise for fighting tumors

Researchers in Penn Vet led a collaborative study that demonstrates how a modified peptide normalizes tumor vasculature and enhances various cancer treatments.
Roy Hamilton encourages tough conversations with grace and compassion
Roy Hamilton.

Roy H. Hamilton, vice dean for Inclusion, Diversity, and Equity.

(Image: Courtesy of Penn Medicine News)

Roy Hamilton encourages tough conversations with grace and compassion

Hamilton, Penn Medicine’s new vice dean for Inclusion, Diversity, and Equity, is dedicating his third decade at the Perelman School of Medicine to making academia a safe, supportive space for students and colleagues alike.

Meredith Mann

To get drivers to put down their phones, make it a game
A person driving pressing a button on a mounted smartphone.

Image: iStock/dusanpetkovic

To get drivers to put down their phones, make it a game

A large trial of strategies to reduce distracted driving presented by Penn Medicine experts show that those that were “gamified” yielded a lasting reduction in handheld phone usage while driving.

Frank Otto

Building solutions for brain disorders
Flavia Vitale holding a vial with a gloved hand.

Flavia Vitale is an associate professor in bioengineering in Penn Engineering and in neurology in Penn Medicine.

(Image: Melissa Pappas)

Building solutions for brain disorders

Penn Engineering’s Flavia Vitale’s work developing devices that help people living with brain disorders has earned her a CAREER award, which will support her lab’s research in materials and devices that interface with different chemical and electrical signals inside the brain.

Melissa Pappas