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A new study finds genome refolding contributes to resistance to cancer therapy
Two cartoon hands holding lines of yarn, twisted into genetic shapes.

If you stretched the DNA fiber packed inside of a single cell, it would reach six feet long from end to end—that’s like fitting a ball of yarn twice the size of Manhattan into a tennis ball. Penn researchers have discovered that the misfolding of DNA can reposition transcription factors and lead to cancer drug resistance. (Image: Penn Medicine News)

A new study finds genome refolding contributes to resistance to cancer therapy

While gene mutations can lead to drug resistance, researchers in the Perelman School of Medicine have identified an important, non-genetic adaptation that could also drive resistance to targeted therapy in T cell leukemia, a type of blood cell cancer.

Lauren Ingeno

One drink a day linked with reduced brain size
A scale with an alcoholic beverage on one side and a brain on the other

One drink a day linked with reduced brain size

The Penn-led research, using a dataset of more than 36,000 adults, revealed that going from one to two drinks a day was associated with changes in the brain equivalent to aging two years. Heavier drinking was linked with an even greater toll.

Katherine Unger Baillie

Links between diet and cancer
Kathryn Wellen in her lab.

Kathryn E. Wellen, an associate professor of cancer biology and principal investigator of the Wellen Lab.

Links between diet and cancer

Kathryn E. Wellen, an associate professor of Cancer Biology and principal investigator of the Wellen Lab, seeks answers to find the connections between metabolism and cancer biology.

From Penn Medicine News

COVID in a cat
Orange cat sleeps on a blanket

COVID in a cat

A new report led by Elizabeth Lennon of the School of Veterinary Medicine and colleagues has confirmed what is believed to be the first published account of the delta variant of SARS-CoV-2 in a house cat.

Katherine Unger Baillie

SARS-CoV-2 is moving between humans and wildlife around the U.S.
Four white-tailed deer in a snow-covered meadow

Recent research at Penn and elsewhere underscores that SARS-CoV-2 has jumped repeatedly between species during the COVID-19 pandemic. 

SARS-CoV-2 is moving between humans and wildlife around the U.S.

In humans the pandemic is showing signs of ebbing. In white-tailed deer and other wildlife, however, infections appear widespread.

Katherine Unger Baillie

COVID-19 vaccines for young children
Preschool children work on art with a teacher

COVID-19 vaccines for young children

As the pandemic enters its third year, kids under five can’t get vaccinated. Researchers explain what’s been unfolding with the vaccine authorization process.

Katherine Unger Baillie

The history, and future, of Black doctors at Penn
Three masked workers hang a portrait of Helen Octavia Dickens on the wall.

The expanded exhibit and new home for Helen Octavia Dickens’ portrait were installed in late August 2021 and dedicated in early December. (Image: Penn Medicine News)

The history, and future, of Black doctors at Penn

A recent article in Penn Medicine magazine highlights four Black graduates and physicians over 200 years, and the ongoing efforts today to build a more diverse and inclusive community.

From Penn Medicine News

Penn receives momentous gift to support Korean studies, neurovascular surgery, and the Wharton School 
James Kim.

Penn alum James Joo-Jin Kim.

Penn receives momentous gift to support Korean studies, neurovascular surgery, and the Wharton School 

The $25 million gift from James Joo-Jin Kim and Agnes Kim, and the James and Agnes Kim Family Foundation will support a range of initiatives at Penn, including the James Joo-Jin Kim Center for Korean Studies in the School of Arts & Sciences.