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New antiviral drug combination is highly effective against SARS-CoV-2
Microscopic view of human respiratory epithelial cells infected with SARS-CoV-2.

Researchers studied the effects of drug combinations on human respiratory epithelial cells infected with SARS-CoV-2. (Image: Nature 2022)

New antiviral drug combination is highly effective against SARS-CoV-2

A Penn Medicine study finds that combining remdesivir or molnupiravir with the experimental drug brequinar blocked the replication of the virus that causes COVID-19 in lung cells.

Lauren Ingeno

Why are alcohol- and drug-related deaths rising in the U.S. and not elsewhere?
Silhouette of a person sitting against a wall on the side of the image, legs pulled up close to her chest.

Why are alcohol- and drug-related deaths rising in the U.S. and not elsewhere?

With insights from anthropology and neuroscience, Penn researchers Michael Platt and Peter Sterling find that, in comparison, 16 other wealthy nations offer communal assistance at every life stage, support that protects individuals and families long term.

Michele W. Berger

Decade-long remission after CAR T cell therapy
Two people stand closely together, smiling

Bill Ludwig, left, was the first patient to receive CAR T cells as part of clinical trials at Abramson Cancer Center. Carl June, right, has played a pioneering roll in the therapeutic use of CAR T cells. (Image: Penn Medicine)

Decade-long remission after CAR T cell therapy

Two patients represent longest-known CAR T cell response to date, providing insight into treatment effect and outcomes.

Caren Begun

Early discharge of healthy newborns during the pandemic
Parent at home with newborn in their arms.

Early discharge of healthy newborns during the pandemic

In a new study, Sara Handley and colleagues find that a shorter stay did not increase infant readmissions in the first week, suggesting that earlier discharge can be done safely.

From Penn LDI

Ten from Penn elected 2021 AAAS Fellows
Researchers Sara Cherry, Susan Davidson, Douglas Durian, Kathleen Hall Jamieson, Katalin Kariko, I. Joseph Kroll, Mingyao Li, Hongjun Song, Duncan Watts, and E. John Wherry

Penn’s new AAAS Fellows for 2021, clockwise from top left: Sara Cherry, Susan Davidson, Douglas Durian, Kathleen Hall Jamieson, Katalin Karikó, I. Joseph Kroll, Mingyao Li, Hongjun Song, Duncan Watts, and E. John Wherry

Ten from Penn elected 2021 AAAS Fellows

Ten scholars representing five schools across the University of Pennsylvania have been named to the 2021 class of American Association for the Advancement of Science Fellows, recognized for their “scientifically and socially distinguished achievements.”

Katherine Unger Baillie

After the shutdown, what comes next for the former Philadelphia Energy Solutions refinery?
philadelphia refinery

Flames and smoke emerge from the Philadelphia Energy Solutions Refining Complex in Philadelphia, Friday, June 21, 2019. (Image: Matt Rourke/AP Images)

After the shutdown, what comes next for the former Philadelphia Energy Solutions refinery?

Creating a greener, more equitable future at the site means understanding its complex history, its long-running public health impacts, and working in partnership with communities.

Erica K. Brockmeier

Racial disparity in follow-up appointments disappears with telemedicine
A patient having a telemedicine appointment with a doctor via a desktop computer screen.

Racial disparity in follow-up appointments disappears with telemedicine

An inequity in the rate of Black patients making it to their primary care appointment after a hospitalization was eliminated after telemedicine became widely used amid the COVID-19 pandemic.

From Penn Medicine News

Busting myths about the Asian American ‘model minority’
Patient with a face mask looking at a computer with a medical professional.

Busting myths about the Asian American ‘model minority’

Two new studies highlight the problem with aggregating diverse groups of people into a single category of “Asian American” when applied to cardiovascular disease and cancer diagnosis and outcomes.

From Penn LDI

A new method to increase effectiveness of nanomedicines
Microscopic view of nanomedicine particles attacked by immune system proteins.

Upon injection into the blood, nanomedicines (blue spheres) are immediately attacked by proteins of the immune system called complement proteins (orange). Complement proteins cause rapid destruction of the nanomedicine, and also induce an anaphylaxis-like reaction. By attaching complement-degrading proteins (yellow ninjas made of protein) to the surface of nanomedicines, Penn researchers have largely solved this problem, potentially allowing more diseases to be safely treated by nanomedicine.(Image: Penn Medicine News)

A new method to increase effectiveness of nanomedicines

Penn Medicine researchers have developed a new technique that uses complement inhibitor Factor I to prevent proteins from attacking treatment-carrying nanoparticles so they can better reach targets within the body.

Sophie Kluthe