Perelman School of Medicine

Test predicts which patients with rare blood disease will respond to treatment

A Penn Medicine study identifies blood proteins that indicate which patients with idiopathic multicentric Castleman disease are most likely to benefit from the only FDA approved treatment for the disease, and uncovers an alternative.

Gloved hand holding a SARS-CoV-2 antibody test.

At-home COVID-19 results with the click of a smartphone

Penn researchers have developed a highly-sensitive rapid antigen test that can detect small loads of SARS-CoV-2.

Person in full PPE administering a vaccine to another person sittting on a hospital bed.

mRNA COVID-19 vaccines induce T-cell responses in multiple sclerosis patients

Research from Penn Medicine shows mRNA COVID-19 vaccines are effective at inducing T-cell responses in multiple sclerosis patients who receive B cell-depleting Infusions even if their antibody responses are diminished.

Hands of person with muscular dystrophy holding a breathing apparatus.

Respiratory care program allows patients with neuromuscular disorders to thrive at home

Penn Medicine’s Jay and Randy Fishman Program for Home Assisted Ventilation has implemented dramatic advances in respiratory support and multidisciplinary care so patients can live safely at home.

microscopic rendering of three solid tumors being attacked by CAR T cells.

Engineering CAR T cells to activate a bodily response to solid tumors

A new Penn study shows that CAR T cells expressing RN7SL1, a naturally occurring RNA, can activate the body’s natural immune cells against difficult-to-treat cancers.

Deborah Culley standing by a railing at the Perelman School of Medicine in a white lab coat.

Deborah J. Culley on her vision for the future of Anesthesiology and Critical Care

Culley discusses her past research on the connection between anesthesia and post-operative cognitive dysfunction and her new role as chair of the Department of Anesthesiology and Critical Care.

A person in a mask holding a clipboard at the bottom of steps outside a home. On the porch are an unmasked adult and two unmasked children.

In hard-hit neighborhoods, Philly CEAL outreach aims to address COVID disparities

Through community engagement and improved information dissemination, researchers at Penn Nursing, Penn Medicine, and Annenberg, in conjunction with the City of Philadelphia, are working to increase vaccination and testing rates and decrease new COVID-19 infections.

Drew Weissman and Katalin Karikó standing side by side.

2022 Breakthrough Prize in Life Sciences awarded to mRNA pioneers Drew Weissman and Katalin Karikó

Weissman and Karikó are honored for engineering modified RNA technology which enabled rapid development of effective COVID-19 vaccines.

Patient and doctor wearing masks, one wearing a gown about to get a mammogram.

Breast cancer diagnosis in the ‘between’ year: Body mass index matters

While breast density—a characteristic that can help tumors hide from mammography—has attracted a lot of attention from clinicians, a new study finds evidence that body mass index, or BMI, is also important, especially in the year between screenings.

Three people as seen from the ground wearing running shoes on a paved running trail.

Choose personal exercise goals, then tackle them immediately

Research from the Perelman School of Medicine reveals that having people set their own fitness goals and pursue them immediately, rather than giving them assigned goals that begin gradually, is most likely to result in lasting positive change.

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