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Unraveling how stem cells from gum tissue accelerate wound healing
Shi, Songtao.stem cells in the gums

To assist with wound healing, mesenchymal stem cells from the gum tissue secrete extracellular vesicles (labeled red) that contain the anti-inflammatory signaling molecule IL-1RA (labeled green). 

Unraveling how stem cells from gum tissue accelerate wound healing

Gum tissue stem cells heal twice as fast as skin, and researchers are determining their potential in accelerated wound healing research.

Katherine Unger Baillie

By altering bone marrow, ‘training’ can prepare innate immune system for future challenges
Hajishengallis, an expert in the immune mechanisms behind the gum disease periodontitis

Hajishengallis, an expert in the immune mechanisms behind the gum disease periodontitis, worked with an international team to show that the innate immune system--typically thought to lack immune memory--can in fact be trained to "remember" past threats.

By altering bone marrow, ‘training’ can prepare innate immune system for future challenges

George Hajishengallis of the School of Dental Medicine and an international team of colleagues have found that “training” the immune system causes changes in the precursors of immune cells in the bone marrow. These changes could facilitate a more robust response to future infections or even enable the immune system to regenerate faster after chemotherapy.

Katherine Unger Baillie

New Dental Material Resists Plaque and Kills Microbes, Penn Dental Team Finds

New Dental Material Resists Plaque and Kills Microbes, Penn Dental Team Finds

Dentists rely on composite materials to perform restorative procedures, such as filling cavities. Yet these materials, like tooth enamel, can be vulnerable to the growth of plaque, the sticky biofilm that leads to tooth decay.

Katherine Unger Baillie

Improving oral cancer diagnosis on many fronts

Improving oral cancer diagnosis on many fronts

A comprehensive dental visit includes more than a cleaning and X-rays; well-trained dentists know they must also take a thorough look inside the oral cavity to spot any potentially unusual lesions that could signal oral cancer.

Katherine Unger Baillie

New Coursera Offering From Penn Explores Ties Between Medicine and Dentistry

New Coursera Offering From Penn Explores Ties Between Medicine and Dentistry

By Erica AndersenDentists and physicians practice health care from different perspectives, however, the oral and general health of their patients are of primary importance to both types of providers. A new online course taught by University of Pennsylvania faculty seeks to highlight the inextricable connections between the two professions.

Katherine Unger Baillie

Penn Oral and Maxillofacial Surgeon Driven by Desire to ‘Make Someone Whole Again’

Penn Oral and Maxillofacial Surgeon Driven by Desire to ‘Make Someone Whole Again’

In his office at the University of Pennsylvania, oral and maxillofacial surgeon Rabie Shanti sits at his computer, clicking through photos of patients he’s operated on.He pulls up an image of a mouth open wide, tongue extended.

Katherine Unger Baillie

Bone Marrow Protein May Be Target for Improving Stem Cell Transplants

Bone Marrow Protein May Be Target for Improving Stem Cell Transplants

Bone marrow contains hematopoetic stem cells, the precursors to every blood cell type. These cells spring into action following bone marrow transplants, bone marrow injury and during systemic infection, creating new blood cells, including immune cells, in a process known as hematopoiesis.

Katherine Unger Baillie