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Understanding the cellular mechanisms driving solid tumors’ robust defense system
A 3D rendering of the tumor microenvironment with cancer cells, T-Cells, nanoparticles, cancer associated fibroblast layer of tumor microenvironment normal cells, molecules, and blood vessels.

In a collaborative interdisciplinary study, Michael Mitchell of the School of Engineering and Applied Science, Wei Guo of the School of Arts & Sciences, and Drew Weissman of the Perelman School of Medicine show that solid tumors can block drug-delivery mechanisms with a “forcefield-like” effect but certain genetic elements that can effectively “shut down” the forcefield. Their findings hint at new targets for delivering cancer treatments that use the body’s immune system to fight tumors.

(Image: iStock / CIPhotos)

Understanding the cellular mechanisms driving solid tumors’ robust defense system

Researchers from Penn have identified a “forcefield-like” defense system in solid tumors and the genetic elements that can switch it off.
The mechanics of collaboration
Portrait of Xinlan Emily Hu

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The mechanics of collaboration

Penn Ph.D. student Xinlan Emily Hu leads a group of budding engineers and social scientists who study communication across teams. The group has developed a new toolkit aimed at helping researchers analyze and measure teamwork.
A climate expert’s return to Penn
Portrait of Jen Wilcox

Jen Wilcox has returned to the Kleinman Center for Energy Policy at the Stuart Weitzman School of Design and to the School of Engineering and Applied Science following three years in at the U.S. Department of Energy, where she served in the Biden Administration as the principal deputy assistant secretary for the Office of Fossil Energy and Carbon Management.

(Image: Courtesy of Jen Wilcox)

A climate expert’s return to Penn

Jen Wilcox, an expert on direct-air capture, is the inaugural faculty appointment in the Kleinman Center and served for three years as principal deputy assistant secretary for the Office of Fossil Energy in the U.S. Department of Energy. She discusses her time away and her return to Penn.
Uncovering new antibiotics inside the human gut
Microscopic rendering of bacterial in the small intestines.

Image: iStock/ChrisChrisW

Uncovering new antibiotics inside the human gut

Researchers from Penn Engineering, led by César de la Fuente, have leveraged AI to discover dozens of potential new antibiotics in the human gut microbiome.

Ian Scheffler

A mission to supercharge scientific research
A doctor using AI and machine learning on a computer.

Image: iStock/ipopba

A mission to supercharge scientific research

Jacob Gardner, an assistant professor in computer and information science, wants to leverage AI to accelerate scientific research across disciplines.

Ian Scheffler

Olympic performance
Ten people singing into microphones on a stage

The Penn Masala a capella group sang in two performances in the India House location at the Olympic Games in Paris. 

(Image: Courtesy of Penn Masala)

Olympic performance

The South Asian a capella student group Penn Masala performed two shows at the India House in Paris during the Olympic Games. They sang hour-long sets before sellout crowds who danced and sang along to mashups in Hindi and English.
Pushing the limits of scientific discovery with machine learning
Computer code.

Image: iStock/iambuff

Pushing the limits of scientific discovery with machine learning

Penn Engineering’s Nat Trask is combining applied mathematics and traditional physics modeling with the powers of machine learning to design some of his first machine-learning-powered, self-driving labs at Penn.

Melissa Pappas

Embracing the power of deep learning in safety-critical systems
From left: Pengyuan Eric Lu, Insup Lee, and Oleg Sokolsky.

From left: Pengyuan Eric Lu and his mentors, Insup Lee, Cecilia Fitler Moore Professor in Computer and Information Science; and Oleg Sokolsky, research professor in CIS.

(Image: Courtesy of Penn Engineering)

Embracing the power of deep learning in safety-critical systems

Pengyuan Eric Lu, a Ph.D. candidate at the Penn Research in Embedded Computing and Integrated Systems Engineering Center, focuses his research on enhancing the reliability and safety of cyber-physical systems, in which “smart” technology interacts with the physical world.

From Penn Engineering