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Cancer Research
Avery Posey’s cancer research takes high risks for big rewards
Avery Posey’s cancer research takes high risks for big rewards
The assistant professor of systems pharmacology and translational therapeutics, who studied with Carl June as a postdoctoral fellow, combines his two research passions—gene therapy and investigating ‘little known’ biology—in the pursuit of new knowledge.
‘Self-eating’ stem cell process may be the key to new regenerative therapies
‘Self-eating’ stem cell process may be the key to new regenerative therapies
A Penn study uncovers new roles of chaperone-mediated autophagy in how stem cells repair or regenerate damaged organs.
Rare genetic mutation leaves people at higher risk for multiple cancers
Rare genetic mutation leaves people at higher risk for multiple cancers
Researchers find a new and previously undiscovered mutation in a particular gene associated with a higher risk of multiple kinds of cancer, and can lead to modified screenings for this particular gene protein.
Glowing dye may aid in eliminating cancer
Glowing dye may aid in eliminating cancer
In dogs with mammary tumors, researchers from the School of Veterinary Medicine and Perelman School of Medicine used a substance that glows under near-infrared light to illuminate cancer.
New cancer immunotherapy targeting myeloid cells slows tumor growth
New cancer immunotherapy targeting myeloid cells slows tumor growth
Researchers found that inhibiting a molecule hijacked by tumor cells to suppress the immune system shrank tumors.
Blocking tumor signals can hinder cancer’s spread
Blocking tumor signals can hinder cancer’s spread
A cross-campus team led by Serge Fuchs of the School of Veterinary Medicine used an inhibitor of an enzyme called p38α kinase to suppress the spread of melanoma to the lungs in a mouse model.
New liver cancer research targets non-cancer cells to blunt tumor growth
New liver cancer research targets non-cancer cells to blunt tumor growth
By targeting senescent cells using “senotherapy,” researchers can greatly reduce tumors in models.
Activating an estrogen receptor can stop pancreatic cancer cells from growing
Activating an estrogen receptor can stop pancreatic cancer cells from growing
Activating the G protein-coupled estrogen receptor has been shown to stop pancreatic cancer from growing, but may also make tumors more visible to the immune system and thus more susceptible to modern immunotherapy.
Kathleen Hall Jamieson, Carl June elected to National Academy of Sciences
Kathleen Hall Jamieson, Carl June elected to National Academy of Sciences
The researchers, from the Annenberg Public Policy Center and the Perelman School of Medicine, join a class of honored scholars recognized for their unique and ongoing contributions to original research.
Blood test may help doctors catch pancreatic cancer early
Blood test may help doctors catch pancreatic cancer early
A blood test may be able to detect the most common form of pancreatic cancer while it is still in its early stages while also helping doctors accurately stage a patient’s disease and guide them to the appropriate treatment.
In the News
Science News
A child who got CAR-T cancer therapy is still disease-free 18 years later
Carl June of the Perelman School of Medicine says that neuroblastoma is the first solid tumor for which there could be curative effects with CAR T cells.
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The Hill
The U.S. is losing its next generation of health scientists
In a co-written opinion essay, James Alwine of the Perelman School of Medicine says that slashing of research funding for NIH and the National Science Foundation will eliminate the next generation of health scientists.
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Interesting Engineering
Scientists create tiny anticancer weapons that make tumors destroy themselves
Xiaowei (George) Xu of the Perelman School of Medicine and colleagues have unveiled an innovative approach to cancer treatment that leverages tiny capsules known as small extracellular vesicles to target a specific receptor on tumor cells.
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HealthDay
Keto diet supplement could boost a cancer treatment's effectiveness
A study by Perelman School of Medicine student Puneeth Guruprasad and postdoc Shan Liu suggests that a component of the keto diet could boost CAR T cell therapy to help treat cancer.
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Forbes
Carl June: 2024 will be seen as a breakthrough year for brain cancer
Carl June of the Perelman School of Medicine shares five insights on using CAR T cell therapy to combat cancer, featuring remarks from Bruce Levine.
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Philadelphia Inquirer
Penn plans to build a proton center for cancer treatment at Presbyterian Medical Center
Penn Medicine will build its fourth proton beam center for cancer treatment at Penn Presbyterian Medical Center in University City.
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