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Illuminating lung cancer earlier, at the cellular level
X-ray of a biopsy with a cancerous cell circled in red.

Scan of a patient in the Penn Medicine led-study with a lung nodule, circled in red. (Image: Penn Medicine News)

Illuminating lung cancer earlier, at the cellular level

A Penn Medicine study reveals that technology combined with an imaging agent can light up microscopic cancer cells, allowing physicians to see cancer cells not typically visible during a biopsy.

Caren Begun

Frozen testicular tissue still viable after 20 years
Cross-section of testes tissue shows a variety of cells labeled pink and blue and sperm

After being transferred to an infertile mouse, testes tissue from a rat that had been frozen for more than two decades gave rise to sperm and germ cells. (Image: Eoin Whelan/PLOS Biology/CC-BY 4.0 https://creativecommons.org/licenses/by/4.0)

Frozen testicular tissue still viable after 20 years

Many pediatric cancer treatments, though lifesaving, can compromise future fertility. In a new study in rodents, researchers from the School of Veterinary Medicine showed that testicular tissue frozen for more than 20 years could give rise to sperm.

Katherine Unger Baillie

Regulating the regulators of the immune system
T cells labeled in fluorescent green patrol the vascular system, labeled in red

Regulating the regulators of the immune system

Research led by School of Veterinary Medicine scientists reveals a new layer of complexity with which the immune system finds a balance between controlling pathogens and protecting healthy tissue.

Katherine Unger Baillie

Key to detecting ovarian cancer early may be in the fallopian tubes
A doctor talking with a patient.

Key to detecting ovarian cancer early may be in the fallopian tubes

A lack of early detection or prevention strategies for ovarian cancer is a major cause of poor outcomes for patients, and most do not have a family history or inherited genetic risk, so there is a pressing need for the development of earlier detection methods.

Caren Begun

CAR T cells suppress GI solid tumor cells without toxicity to healthy tissue
Microscopic view of T cells.

CDH17 CAR T cells attack a tumor but spare healthy tissue. (Image: Penn Medicine News)

CAR T cells suppress GI solid tumor cells without toxicity to healthy tissue

New research finds that CAR T cells can eliminate solid tumors, but do not damage healthy, normal tissues that also express a tumor antigen, because the tumor antigen is sequestered and hidden between the normal cells.

Caren Begun

A new study finds genome refolding contributes to resistance to cancer therapy
Two cartoon hands holding lines of yarn, twisted into genetic shapes.

If you stretched the DNA fiber packed inside of a single cell, it would reach six feet long from end to end—that’s like fitting a ball of yarn twice the size of Manhattan into a tennis ball. Penn researchers have discovered that the misfolding of DNA can reposition transcription factors and lead to cancer drug resistance. (Image: Penn Medicine News)

A new study finds genome refolding contributes to resistance to cancer therapy

While gene mutations can lead to drug resistance, researchers in the Perelman School of Medicine have identified an important, non-genetic adaptation that could also drive resistance to targeted therapy in T cell leukemia, a type of blood cell cancer.

Lauren Ingeno

Links between diet and cancer
Kathryn Wellen in her lab.

Kathryn E. Wellen, an associate professor of cancer biology and principal investigator of the Wellen Lab.

Links between diet and cancer

Kathryn E. Wellen, an associate professor of Cancer Biology and principal investigator of the Wellen Lab, seeks answers to find the connections between metabolism and cancer biology.

From Penn Medicine News

Inspiring people, place, and purpose
penn president amy gutmann

Inspiring people, place, and purpose

Penn President Amy Gutmann’s record tenure of nearly 18 years is the University’s most transformative.

Penn Today Staff