Cancer Research | Penn Today

Personalized immunotherapy shows promise beyond cancer

Carl June of the Perelman School of Medicine is interviewed on the use of customized immunotherapy to treat new blood cancers, as well as its potential for treating solid state cancers and autoimmune diseases.

Gregory L. Beatty holds up a fluid sample in a lab setting.

Losing mom to brain cancer fuels an expert’s mission for breakthrough

Research by Gregory L. Beatty, who lost his mother to glioblastoma, and colleagues have found that immunotherapy might have some activity in patients with relapsed tumors, and a potential target location for immunotherapy in glioblastoma tumors.

four panels show a cancerous tumor with some portions labeled in red, green, and blue, and a close up image of part of it

Cancer cells selectively load ‘drones’ to keep T cells from infiltrating tumors

Biologist Wei Guo and colleagues elucidate the process of sorting and loading cargo for these biological drones with implications for a more targeted and effective use of checkpoint inhibitor drugs in cancer treatment.

microscopic image of an immune cell labeled purple against a gray background

Deconstructing the mechanics of bone marrow disease

A new understanding of how mechanical features of bone marrow affect resident immune cells in a fibrotic cancer points to future therapeutic strategies for cancers and fibrotic diseases.

Some cancer patients forgo lifesaving medications because of high cost

PIK Professor Ezekiel Emanuel comments on the problem with the Food and Drug Administration’s accelerated approval program for new cancer drugs.

‘Watershed moment’: Doctors finding new hope in treatments for deadly pancreatic cancer

Robert Vonderheide of the Perelman School of Medicine’s Abramson Cancer Center says a big breakthrough in cancer treatment will come soon.

One protein’s role in genomic intermingling and T cell development

The findings, from a team led by Golnaz Vahedi of Penn Medicine, could have implications for T-cell based immunotherapies for cancer and other conditions.

Stress protein in fibroblasts may be a good target for future cancer drugs

A Penn study finds the ATF4 protein is overactive in many types of tumor cells and tumor-supporting fibroblasts to promote tumor survival, and may be a good target for future cancer treatments.

Blood tests that detect cancers create risks for those who use them

Susan Domchek of the Perelman School of Medicine warns that when large numbers of people get tested for cancer false positives become a real problem.

A chemotherapy drip solution hanging by a sunlit window.

Promising results for chemo immunotherapy combination against pancreatic cancer

Penn Medicine researchers find a combination of chemotherapy with an immunotherapy meant to unleash the anticancer capacity of the immune system is effective against pancreatic cancer. The findings also include the identification of immune system biomarkers associated with better outcomes.

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