Cancer Research | Penn Today

Another Crispr first: New treatment wipes out teen’s cancer

Bruce Levine of the Perelman School of Medicine says that the latest results of Crispr gene editing in a cancer patient have showcased the best possible clinical outcome thus far.

CRISPR gene-editing may boost cancer immunotherapy, new study finds

Carl June of the Perelman School of Medicine says that off-the-shelf CAR-T cell therapies using CRISPR would be a game-changer.

Microscopic view of a DNA chain with a genetic mutation.

Study shows promise of new anti-KRAS drug for pancreatic cancer

A small molecule inhibitor that attacks the difficult cancer-causing gene mutation KRAS successfully shrunk tumors or stopped cancer growth in preclinical models of pancreatic cancer.

HPV-related cancers are on the rise in men

Recent CDC data show that roughly four of every 10 cases of HPV-induced cancer now occur in men. Penn Medicine research has found that differences in levels of a particular HPV protein may inform treatment.

Cancer patient with IV drip and scarf on their hair looks out the window.

CAR T cell therapy reaches beyond cancer

Penn Medicine researchers laud the early results for CAR T therapy in lupus patients, which point to broader horizons for the use of personalized cellular therapies.

Dogs may hold key to treating cancer in humans

A study by Nicola Mason of the School of Veterinary Medicine and colleagues found that an experimental immunotherapy treatment using genetically modified listeria could extend the life expectancy of dogs with cancer.

nurse helping elderly person cross the street with a walker

Home health care—a crucial edge for the future of medicine

Home care has long been a part of health care, but it was the COVID-19 pandemic that led Penn Medicine to rethink who needed to be in the hospital.

Gloved hands putting individual tiny pipettes in a holder in a lab setting.

Why cancers caused by BRCA mutations recur

Findings from Penn Medicine uncover possible drivers of recurrent breast and ovarian cancers among women carrying high-risk genetic mutations, pointing to methods to more effectively treat disease.

CRISPR cancer trial success paves the way for personalized treatments

Joseph Fraietta of the Perelman School of Medicine explains the complicated manufacturing process behind T-cell cancer therapies.

Meg Ruller with her dog Maple in front of Penn Vet

A FLASH of radiation may pave the way toward new cancer care for people and pets alike

Led by the Perelman School of Medicine’s Keith Cengel and the School of Veterinary Medicine’s Brian Flesner, a new study is evaluating the safety and efficacy of treating oral cancer in dogs with a palliative radiation in just two clinic visits.

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