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Kotaro Sasaki and his team unveil the genetics of testicular cancer
Microscopic image of seminoma tissue. The image shows green-stained cells representing early-stage germ cells, red-stained areas indicating high gene activity linked to cancer growth, and gray-stained nuclei of various cells
Section of seminoma tissue, a type of testicular cancer, showing strong expression of proteins/RNAs (TFAP2C, green; BICD1, red) that are typically present in pre-migratory/migratory primordial germ cells, precursors of sperm.

(Image: Courtesy of Kotaro Sasaki)

Kotaro Sasaki and his team unveil the genetics of testicular cancer

Researchers from Penn Vet develop the first in vitro seminoma model, shedding light on chromosomal anomalies and signaling pathways.
Josephine Park on authoring identity
Josephine Park.

Josephine Park, School of Arts & Sciences President’s Distinguished Professor of English.

(Image: Courtesy of OMNIA)

Josephine Park on authoring identity

The School of Arts & Sciences President’s Distinguished Professor of English discusses the way literature has influenced the experience of being Asian American in the United States.

Blake Cole

Weitzman’s Rossana Hu on adaptive reuse and historic architecture
Rossana Hu.

Rossana Hu, Miller Professor and Chair of Architecture.

(Image: Eric Sucar)

Weitzman’s Rossana Hu on adaptive reuse and historic architecture

Hu, the Miller Professor and chair of the Department of Architecture, takes a “common sense” approach to adaptive reuse in her design work and teaching.

From the Weitzman School of Design

Researchers upend theory about the formation of the Milky Way Galaxy
Visualization of a ‘wrinkly’ halo of stars around the Milky Way.

This image visualizes the Milky Way and its surrounding “halo” of stars. Most stars in the Milky Way lie in the disc (like the Sun, for example), but stars from past collisions end up in the halo, a large “cloud” of stars that extends outwards in all directions. These halo stars have been enhanced in this image, but in reality would be very dim compared to the disc. The halo appears messy and “wrinkly” here, a sign that a merger has occurred relatively recently.

(Image: Halo stars: ESA/Gaia/DPAC, T Donlon et al. 2024; Background Milky Way and Magellanic Clouds: Stefan Payne-Wardenaar)

Researchers upend theory about the formation of the Milky Way Galaxy

New findings by Robyn Sanderson and collaborators suggest galaxy’s last major collision was billions of years later than previously thought.
Fruitful insights on the brain
Photograph of researcher, China Byrns, in front of monitor showing microscopy images of fly brain

China Byrns used high-magnification confocal microscopy to visualize senescent glia (red) in Drosophila brains as part of a multidisciplinary approach to define the origin and effects of senescent cells in brain aging.

(Image: Courtesy of Riya Anand)

Fruitful insights on the brain

Research led by China Byrns of the lab of Nancy M. Bonini in the School of Arts & Sciences have uncovered new details about the role of zombie-like cells in brain aging, using the fruit fly as a model.
New insights on cellular clones and inflammation in bones
Hajishengallis, an expert in the immune mechanisms behind the gum disease periodontitis

Hajishengallis, an expert in the immune mechanisms behind the gum disease periodontitis, worked with an international team to show that the innate immune system--typically thought to lack immune memory--can in fact be trained to "remember" past threats.

New insights on cellular clones and inflammation in bones

Research led by George Hajishengallis of Penn Dental sheds light on an aging-related condition that drives inflammation in older populations.
Penn Engineering’s Ottman Tertuliano receives a 2024 CAREER Award
Ottman Tertuliano.

Image: Courtesy of Penn Engineering

Penn Engineering’s Ottman Tertuliano receives a 2024 CAREER Award

Tertuliano’s research on bone fractures at the nanoscale allows for research on two separate time scales: the forming of cracks in a fracture at 1 micrometer/second, and the cellular response and repair time scale, a much lengthier process.

From Penn Engineering Today