For kids with rare genetic disorders, customized CRISPR treatments offer hope Penn In the News NPR For kids with rare genetic disorders, customized CRISPR treatments offer hope Scientists at Penn are trying to develop a template for groups of rare conditions that are similar enough to be affected by a single, easily adaptable gene-editing treatment. A Philly biotech got $60M from a TED initiative for AI in medicine Penn In the News Philadelphia Inquirer A Philly biotech got $60M from a TED initiative for AI in medicine David Fajgenbaum of the Perelman School of Medicine helped found Every Cure, a biotechnology nonprofit that employs AI to help match existing treatments to new diseases. An integral T cell pathway helps regulate female gene expression Image: iStock/Alllex An integral T cell pathway helps regulate female gene expression Penn Vet researchers have revealed a connection between NF-κB signaling pathways and X chromosome inactivation, which has implications for understanding sex-based immune responses during infection. Understanding diabetes and oral health From left: Su Ah Kim, professor of periodontics Dana Graves, and Sanan Gueyikian.nocred Understanding diabetes and oral health Two undergraduates, supported by PURM, worked on research projects this summer with the Graves Lab to contribute to the knowledge of diabetes’ impact on oral wound healing and periodontal disease. Study of gender-affirming care reveals immune system sex differences Penn In the News Stat Study of gender-affirming care reveals immune system sex differences Montserrat Anguera of the Perelman School of Medicine and the School of Veterinary Medicine comments on the work to comprehensively examine the impact of gender-affirming care on the immune system. Uncovering new antibiotics inside the human gut Image: iStock/ChrisChrisW Uncovering new antibiotics inside the human gut Researchers from Penn Engineering, led by César de la Fuente, have leveraged AI to discover dozens of potential new antibiotics in the human gut microbiome. A disease that makes children age rapidly gets closer to a cure Penn In the News The New York Times A disease that makes children age rapidly gets closer to a cure Kiran Musunuru of the Perelman School of Medicine says there’s no guarantee that gene editing which worked well in mice will also work with human patients. She’s fighting to stop the brain disease that killed her mother before it gets her Penn In the News USA Today She’s fighting to stop the brain disease that killed her mother before it gets her Kiran Musunuru of the Perelman School of Medicine comments on shutting off genetic signals in the brain to hold off diseases. Rare disease’s DNA-damaging mutation could have consequences for more common conditions Image: iStock/piyaset Rare disease’s DNA-damaging mutation could have consequences for more common conditions In their pursuit to discover the mechanism behind how the deadly rare disease RVCL does its damage, Penn Medicine researchers found some clues to the DNA damage theory of aging. How deadly parasites choose to be male Penn Vet researchers developed the Cryptosporidium single-cell atlas, revealing which genes are expressed at which points across the parasite’s life cycle. On the left, the atlas shows parasites replicating asexually in green, with males in blue and females in pink. On the right, micrographs of the stages are shown, with their nuclei highlighted in green.(Image: Boris Striepen) How deadly parasites choose to be male Penn Vet researchers reveal the gene expression across the life cycle of Cryptosporidium and identify the determinant of maleness. Load More
A Philly biotech got $60M from a TED initiative for AI in medicine Penn In the News Philadelphia Inquirer A Philly biotech got $60M from a TED initiative for AI in medicine David Fajgenbaum of the Perelman School of Medicine helped found Every Cure, a biotechnology nonprofit that employs AI to help match existing treatments to new diseases. An integral T cell pathway helps regulate female gene expression Image: iStock/Alllex An integral T cell pathway helps regulate female gene expression Penn Vet researchers have revealed a connection between NF-κB signaling pathways and X chromosome inactivation, which has implications for understanding sex-based immune responses during infection. Understanding diabetes and oral health From left: Su Ah Kim, professor of periodontics Dana Graves, and Sanan Gueyikian.nocred Understanding diabetes and oral health Two undergraduates, supported by PURM, worked on research projects this summer with the Graves Lab to contribute to the knowledge of diabetes’ impact on oral wound healing and periodontal disease. Study of gender-affirming care reveals immune system sex differences Penn In the News Stat Study of gender-affirming care reveals immune system sex differences Montserrat Anguera of the Perelman School of Medicine and the School of Veterinary Medicine comments on the work to comprehensively examine the impact of gender-affirming care on the immune system. Uncovering new antibiotics inside the human gut Image: iStock/ChrisChrisW Uncovering new antibiotics inside the human gut Researchers from Penn Engineering, led by César de la Fuente, have leveraged AI to discover dozens of potential new antibiotics in the human gut microbiome. A disease that makes children age rapidly gets closer to a cure Penn In the News The New York Times A disease that makes children age rapidly gets closer to a cure Kiran Musunuru of the Perelman School of Medicine says there’s no guarantee that gene editing which worked well in mice will also work with human patients. She’s fighting to stop the brain disease that killed her mother before it gets her Penn In the News USA Today She’s fighting to stop the brain disease that killed her mother before it gets her Kiran Musunuru of the Perelman School of Medicine comments on shutting off genetic signals in the brain to hold off diseases. Rare disease’s DNA-damaging mutation could have consequences for more common conditions Image: iStock/piyaset Rare disease’s DNA-damaging mutation could have consequences for more common conditions In their pursuit to discover the mechanism behind how the deadly rare disease RVCL does its damage, Penn Medicine researchers found some clues to the DNA damage theory of aging. How deadly parasites choose to be male Penn Vet researchers developed the Cryptosporidium single-cell atlas, revealing which genes are expressed at which points across the parasite’s life cycle. On the left, the atlas shows parasites replicating asexually in green, with males in blue and females in pink. On the right, micrographs of the stages are shown, with their nuclei highlighted in green.(Image: Boris Striepen) How deadly parasites choose to be male Penn Vet researchers reveal the gene expression across the life cycle of Cryptosporidium and identify the determinant of maleness. Load More
An integral T cell pathway helps regulate female gene expression Image: iStock/Alllex An integral T cell pathway helps regulate female gene expression Penn Vet researchers have revealed a connection between NF-κB signaling pathways and X chromosome inactivation, which has implications for understanding sex-based immune responses during infection.
Understanding diabetes and oral health From left: Su Ah Kim, professor of periodontics Dana Graves, and Sanan Gueyikian.nocred Understanding diabetes and oral health Two undergraduates, supported by PURM, worked on research projects this summer with the Graves Lab to contribute to the knowledge of diabetes’ impact on oral wound healing and periodontal disease.
Study of gender-affirming care reveals immune system sex differences Penn In the News Stat Study of gender-affirming care reveals immune system sex differences Montserrat Anguera of the Perelman School of Medicine and the School of Veterinary Medicine comments on the work to comprehensively examine the impact of gender-affirming care on the immune system. Uncovering new antibiotics inside the human gut Image: iStock/ChrisChrisW Uncovering new antibiotics inside the human gut Researchers from Penn Engineering, led by César de la Fuente, have leveraged AI to discover dozens of potential new antibiotics in the human gut microbiome. A disease that makes children age rapidly gets closer to a cure Penn In the News The New York Times A disease that makes children age rapidly gets closer to a cure Kiran Musunuru of the Perelman School of Medicine says there’s no guarantee that gene editing which worked well in mice will also work with human patients. She’s fighting to stop the brain disease that killed her mother before it gets her Penn In the News USA Today She’s fighting to stop the brain disease that killed her mother before it gets her Kiran Musunuru of the Perelman School of Medicine comments on shutting off genetic signals in the brain to hold off diseases. Rare disease’s DNA-damaging mutation could have consequences for more common conditions Image: iStock/piyaset Rare disease’s DNA-damaging mutation could have consequences for more common conditions In their pursuit to discover the mechanism behind how the deadly rare disease RVCL does its damage, Penn Medicine researchers found some clues to the DNA damage theory of aging. How deadly parasites choose to be male Penn Vet researchers developed the Cryptosporidium single-cell atlas, revealing which genes are expressed at which points across the parasite’s life cycle. On the left, the atlas shows parasites replicating asexually in green, with males in blue and females in pink. On the right, micrographs of the stages are shown, with their nuclei highlighted in green.(Image: Boris Striepen) How deadly parasites choose to be male Penn Vet researchers reveal the gene expression across the life cycle of Cryptosporidium and identify the determinant of maleness. Load More
Uncovering new antibiotics inside the human gut Image: iStock/ChrisChrisW Uncovering new antibiotics inside the human gut Researchers from Penn Engineering, led by César de la Fuente, have leveraged AI to discover dozens of potential new antibiotics in the human gut microbiome.
A disease that makes children age rapidly gets closer to a cure Penn In the News The New York Times A disease that makes children age rapidly gets closer to a cure Kiran Musunuru of the Perelman School of Medicine says there’s no guarantee that gene editing which worked well in mice will also work with human patients. She’s fighting to stop the brain disease that killed her mother before it gets her Penn In the News USA Today She’s fighting to stop the brain disease that killed her mother before it gets her Kiran Musunuru of the Perelman School of Medicine comments on shutting off genetic signals in the brain to hold off diseases. Rare disease’s DNA-damaging mutation could have consequences for more common conditions Image: iStock/piyaset Rare disease’s DNA-damaging mutation could have consequences for more common conditions In their pursuit to discover the mechanism behind how the deadly rare disease RVCL does its damage, Penn Medicine researchers found some clues to the DNA damage theory of aging. How deadly parasites choose to be male Penn Vet researchers developed the Cryptosporidium single-cell atlas, revealing which genes are expressed at which points across the parasite’s life cycle. On the left, the atlas shows parasites replicating asexually in green, with males in blue and females in pink. On the right, micrographs of the stages are shown, with their nuclei highlighted in green.(Image: Boris Striepen) How deadly parasites choose to be male Penn Vet researchers reveal the gene expression across the life cycle of Cryptosporidium and identify the determinant of maleness. Load More
She’s fighting to stop the brain disease that killed her mother before it gets her Penn In the News USA Today She’s fighting to stop the brain disease that killed her mother before it gets her Kiran Musunuru of the Perelman School of Medicine comments on shutting off genetic signals in the brain to hold off diseases. Rare disease’s DNA-damaging mutation could have consequences for more common conditions Image: iStock/piyaset Rare disease’s DNA-damaging mutation could have consequences for more common conditions In their pursuit to discover the mechanism behind how the deadly rare disease RVCL does its damage, Penn Medicine researchers found some clues to the DNA damage theory of aging. How deadly parasites choose to be male Penn Vet researchers developed the Cryptosporidium single-cell atlas, revealing which genes are expressed at which points across the parasite’s life cycle. On the left, the atlas shows parasites replicating asexually in green, with males in blue and females in pink. On the right, micrographs of the stages are shown, with their nuclei highlighted in green.(Image: Boris Striepen) How deadly parasites choose to be male Penn Vet researchers reveal the gene expression across the life cycle of Cryptosporidium and identify the determinant of maleness.
Rare disease’s DNA-damaging mutation could have consequences for more common conditions Image: iStock/piyaset Rare disease’s DNA-damaging mutation could have consequences for more common conditions In their pursuit to discover the mechanism behind how the deadly rare disease RVCL does its damage, Penn Medicine researchers found some clues to the DNA damage theory of aging.
How deadly parasites choose to be male Penn Vet researchers developed the Cryptosporidium single-cell atlas, revealing which genes are expressed at which points across the parasite’s life cycle. On the left, the atlas shows parasites replicating asexually in green, with males in blue and females in pink. On the right, micrographs of the stages are shown, with their nuclei highlighted in green.(Image: Boris Striepen) How deadly parasites choose to be male Penn Vet researchers reveal the gene expression across the life cycle of Cryptosporidium and identify the determinant of maleness.