Through
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Genetics
Researchers identify novel genetic variants linked to Type 2 diabetes
Researchers identify novel genetic variants linked to Type 2 diabetes
Largest-ever study of its kind finds variants that may predispose some people to develop the disease and related conditions like coronary heart disease and chronic kidney disease.
Parasites and the microbiome
Parasites and the microbiome
In a study of ethnically diverse people from Cameroon, the presence of a parasite infection was closely linked to the make-up of the gastrointestinal microbiome, according to a research team led by Penn scientists.
DNA misfolding in white blood cells increases risk for Type 1 diabetes
DNA misfolding in white blood cells increases risk for Type 1 diabetes
A new Penn Medicine study shows that changes in a DNA sequence may cause chromosomes to misfold in a way that elevates the risk for autoimmune diseases.
How our ‘birth environment’ can influence our health
How our ‘birth environment’ can influence our health
Mary Regina Boland studies how one’s “birth environment,” or the factors that a mother experienced while pregnant, affects health risks later in life, and what can actually be predicted while still in the womb.
Three Penn faculty named 2020 Sloan Research Fellows
Three Penn faculty named 2020 Sloan Research Fellows
Engineer Liang Feng, neuroscientist Erica Korb, and statistician Weijie Su each received the competitive and prestigious award honoring early-career researchers.
Do DIY DNA kits revive a harmful perceived link between genetics and race?
Do DIY DNA kits revive a harmful perceived link between genetics and race?
Research from sociologist Wendy Roth reveals that on average, these tests don’t reinforce the idea of essentialism, but how much participants know about genetics going in matters.
Uncovering a defective sperm epigenome that leads to male infertility
Uncovering a defective sperm epigenome that leads to male infertility
A new mouse model allows researchers to track defective sperm and potentially find ways to correct it.
This genetic variant is underdiagnosed, under-recognized, and deadly
This genetic variant is underdiagnosed, under-recognized, and deadly
A genetic variant which is found in about 3 percent of individuals of African ancestry is a more significant cause of heart failure than previously believed, according to a multi-institution study led by researchers at Penn Medicine.
The view from inside the ‘medical scandal’ of China’s gene-edited babies
The view from inside the ‘medical scandal’ of China’s gene-edited babies
In a Q&A, geneticist Kiran Musunuru describes his unintentional connection to the scientist behind the scandal and the book that came out of the experience.
Reprogramming ant ‘soldiers’
Reprogramming ant ‘soldiers’
A Penn study reveals the epigenetic pathway that controls social behavior in carpenter ants, finding that the ants reprogram up to five days after they hatch, while reprogramming was ineffective at the 10-day mark.
In the News
The Washington Post
FDA approves two sickle cell therapies, including first CRISPR medicine
Kiran Musunuru of the Perelman School of Medicine says that gene editing will be the biggest story of the century.
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Philadelphia Inquirer
More than 260,000 Penn Medicine patients have agreed to share their DNA for research, and the discoveries are just getting started
More than 260,000 people have signed up to participate in Penn Medicine BioBank, co-directed by Marilyn Ritchie and Dan Rader, which cross-references DNA with electronic health records to discover genetic variants of medical conditions.
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Philadelphia Inquirer
Jim Wilson has two new promising gene therapy studies, but says investment in the cutting-edge field has ‘gotten worse’
Jim Wilson of the Perelman School of Medicine has published two new studies supporting the promise of cutting-edge gene therapy, finding evidence that the genetic treatments can be beneficial for years without raising the risk of cancer.
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Smithsonian Magazine
Famed 5,300-year-old Alps Iceman was a balding middle-aged man with dark skin and eyes
Iain Mathieson of the Perelman School of Medicine says that the Iceman genome was one of the first ancient human genomes ever published.
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WHYY (Philadelphia)
Philly gene therapy companies tap into city’s workforce training program for lab techs
Penn Medicine is noted for spearheading gene therapy for cancer treatment, being the first in the nation to use a gene editing tool to combat cancer in 2019.
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Philadelphia Inquirer
These eight diseases are so rare that drug firms haven’t tried treating them with gene therapy. A $97 million program aims to help
Gene therapy for a rare form of blindness will be tested at Penn Medicine while gene therapy for a condition that causes skeletal deformities and seizures will be tested at the Children’s Hospital of Philadelphia.
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