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Imaging technology maps cells tied to inflammatory bowel disease
Microscopic multicolor image of a colon.

Multicolor image of a colon from a patient with ulcerative colitis stained by imaging mass cytometry. (Image: Courtesy of Ayano Kondo from the Kaestner Lab)

Imaging technology maps cells tied to inflammatory bowel disease

“Imaging mass cytometry” shows how cells tied to inflammatory bowel disease affect intestinal tissue, generating new theories for the progression of Crohn’s disease and ulcerative colitis.

From Penn Medicine News

Test predicts which patients with rare blood disease will respond to treatment
David Fajgenbaum in his lab.

David Fajgenbaum is an assistant professor of medicine at the Perelman School of Medicine at the University of Pennsylvania and associate director of patient impact in the Penn Orphan Disease Center. He also leads the Castleman Disease Research Program.

(Image: Courtesy of Penn Medicine)

Test predicts which patients with rare blood disease will respond to treatment

A Penn Medicine study identifies blood proteins that indicate which patients with idiopathic multicentric Castleman disease are most likely to benefit from the only FDA approved treatment for the disease, and uncovers an alternative.

From Penn Medicine News

Protein’s ‘silent code’ affects how cells move
six panels showing cells in green with protein involved in cell movement labeled in red

Protein’s ‘silent code’ affects how cells move

A School of Veterinary Medicine-led study shows how, despite having nearly identical amino acid sequences, two forms of the protein actin differ in function due their distinct nucleotide sequences.

Katherine Unger Baillie

The use and misuse of race in health care
drawing of diverse group of people
  • Q&A

    • The use and misuse of race in health care

    In a Q&A, PIK Professor Sarah Tishkoff, the Perelman School of Medicine’s Giorgio Sirugo, and Case Western Reserve University’s Scott Williams shed light on the “quagmire” of race, ethnicity, genetic ancestry, and environmental factors and their contribution to health disparities.

    Katherine Unger Baillie

    Pinpointing how cancer cells turn aggressive
    Concentric circles with different colors inside representing cancer cell lineages

    Pinpointing how cancer cells turn aggressive

    Penn scientists have developed a new method for tracing the lineage and gene expression patterns of metastatic cancer at the single-cell level.

    Katherine Unger Baillie

    How humans evolved a super-high cooling capacity
    Person wiping sweat from their brow with a towel under the sun.

    How humans evolved a super-high cooling capacity

    The higher density of sweat glands in humans is due, to a great extent, to accumulated changes in a regulatory region of DNA that drives the expression of a sweat gland-building gene, explaining why humans are the sweatiest of the Great Apes.

    From Penn Medicine News