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Immunology

Harnessing an innate protection against Ebola
fluorescent microscopic image of two cells being infected with virus

An innate mechanism in human cells may prevent Ebola virus from spreading, according to new Penn Vet-led research. Using powerful confocal microscopy, they tracked the budding of virus-like particles from cells (shown in the filamentous projections in the cell in the upper right) and how autophagy, a “self-eating” cellular process, by which viral proteins are sequestered in vesicles (shown in the cell in the lower left), inhibits virus-like particles from exiting.

(Image: Courtesy of the Harty lab)

Harnessing an innate protection against Ebola

School of Veterinary Medicine researchers have identified a cellular pathway that keeps Ebola virus from exiting human cells, with implications for developing new antivirals.

Katherine Unger Baillie

Five things to know about this year’s ‘tripledemic’
two young people wearing lie under a blanket on a couch, looking sick

Image: iStock/Srdjanns74

Five things to know about this year’s ‘tripledemic’

The Perelman School of Medicine’s E. John Wherry and Scott Hensley discuss the season’s confluence of COVID-19, influenza, and RSV and how our bodies are responding.

Katherine Unger Baillie

CAR T cell therapy may eliminate tumor cells missed by surgery
Microscopic rendering of t cells targeting a tumor cell with a target symbol.

CAR T cell therapy may eliminate tumor cells missed by surgery

The results of a study led by Penn Medicine’s Carl June greenlights preclinical trials for the application of CAR T therapy in gel form to surgical wounds following partial tumor removal to eliminate residual tumor cells.

From Penn Medicine News