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Immunology

CAR T cell therapy may eliminate tumor cells missed by surgery
Microscopic rendering of t cells targeting a tumor cell with a target symbol.

CAR T cell therapy may eliminate tumor cells missed by surgery

The results of a study led by Penn Medicine’s Carl June greenlights preclinical trials for the application of CAR T therapy in gel form to surgical wounds following partial tumor removal to eliminate residual tumor cells.

From Penn Medicine News

What’s next for mRNA vaccines
MIT Technology Review

What’s next for mRNA vaccines

Norbert Pardi of the Perelman School of Medicine and colleagues are developing a universal mRNA flu vaccine, featuring remarks from mRNA pioneer Katalin Karikó.

TAU establishes center for autoimmune research
Jerusalem Post

TAU establishes center for autoimmune research

The Penn Colton Center for Autoimmunity at the Perelman School of Medicine is noted for its experimental and theoretical studies in immunology.

Advances in cancer research
Microscopic rendering of interleukin 18 protein.

Interleukin-18 is a protein which in humans is encoded by the IL18 gene. “We designed an ‘armored’ CAR that secretes IL18 where we found it to have potent antitumor efficacy in our preclinical studies,” said Carl June. (Image: Penn Medicine News)

Advances in cancer research

Recent research shows promise in a novel CAR T therapy after cancer relapse, and a novel treatment for multiple myeloma.

From Penn Medicine News

‘Tripledemic’ underscores vaccine need
China Daily

‘Tripledemic’ underscores vaccine need

Scott Hensley of the Perelman School of Medicine and colleagues are developing a universal influenza vaccine that could prevent the next pandemic.

U.S. flu hospitalizations highest in a decade
Smithsonian Magazine

U.S. flu hospitalizations highest in a decade

Scott Hensley of the Perelman School of Medicine is nervous about the high rates of flu hospitalization and death going into the holiday season.