11/15
Immunology
Scratching beneath the surface of itchy skin
Scratching beneath the surface of itchy skin
Researchers from Penn Vet provide insights into how a species of worms found a way around the mammalian urge to scratch an itch.
An integral T cell pathway helps regulate female gene expression
An integral T cell pathway helps regulate female gene expression
Penn Vet researchers have revealed a connection between NF-κB signaling pathways and X chromosome inactivation, which has implications for understanding sex-based immune responses during infection.
Combo immunotherapy produces distinct waves of cancer-fighting T cells
Combo immunotherapy produces distinct waves of cancer-fighting T cells
Researchers from Penn’s Abramson Cancer Center have found that a novel tool that tracks immune health over time has revealed new insights on immune cell activation.
A newly identified immune checkpoint protein may lead to future cancer therapies
A newly identified immune checkpoint protein may lead to future cancer therapies
Penn Medicine researchers have found that knocking out a T cell’s CD5 gene greatly enhances the cell’s anticancer activity in a variety of preclinical cancer models.
New ‘armored’ CAR therapy produces significant responses in cancer patients
New ‘armored’ CAR therapy produces significant responses in cancer patients
For patients whose cancers don't respond to current CAR T cell therapies, a new, modified CAR T cell therapy by Penn’s Carl June shows promise in a phase 1 clinical trial.
Honoring a life scientist’s lifesaving science
Honoring a life scientist’s lifesaving science
Carl June accepted the 2024 Breakthrough Prize in Life Sciences at a Los Angeles ceremony, making him the sixth recipient from Penn.
Study reveals inequities in access to transformative CAR T cell therapy
Study reveals inequities in access to transformative CAR T cell therapy
Penn Medicine researchers have assessed the percentage of patients from minority health populations and reveal inequities in access to transformative CAR T cell therapy.
Accelerating CAR T cell therapy: Lipid nanoparticles speed up manufacturing
Accelerating CAR T cell therapy: Lipid nanoparticles speed up manufacturing
Penn Engineers have developed a novel method for manufacturing CAR T cells using lipid nanoparticles as delivery vehicles.
Initial SARS-CoV-2 vaccinations prime immune cells to respond to subsequent variants
Initial SARS-CoV-2 vaccinations prime immune cells to respond to subsequent variants
Immunological imprinting from the original ancestral SARS-CoV-2 strain has a significant impact on the antibody responses to the variants and boosters based on them.
Mapping pancreatic cancer to improve immunotherapy
Mapping pancreatic cancer to improve immunotherapy
Gregory L. Beatty, an associate professor of hematology-oncology and member of Penn Medicine’s Abramson Cancer Center, and his team focus on improving immunotherapy for pancreatic cancer.
In the News
ScienceFriday.com
CAR-T cell therapies show promise for autoimmune diseases
Daniel Baker, a Ph.D. student in Carl June’s lab at the Perelman School of Medicine, discusses the results of a study on donor CAR-T cell therapy.
FULL STORY →
Live Science
‘Any protein you can imagine, it can deliver’: AI will help discover the next breakthrough in RNA, says Nobel Prize winner Dr. Drew Weissman
Drew Weissman of the Perelman School of Medicine is launching a new RNA research hub that will use artificial intelligence to help train scientists and guide their experiments.
FULL STORY →
Nature
Is bird flu spreading among people? Data gaps leave researchers in the dark
Scott Hensley of the Perelman School of Medicine says that there are fears of bird flu spreading at low levels through humans in a Missouri community.
FULL STORY →
Forbes
Carl June: 2024 will be seen as a breakthrough year for brain cancer
Carl June of the Perelman School of Medicine shares five insights on using CAR T cell therapy to combat cancer, featuring remarks from Bruce Levine.
FULL STORY →
Women’s Health
How to make yourself sneeze and find relief fast, according to doctors
John V. Bosso of the Perelman School of Medicine says that sneezing helps clear the nose of irritants, dirt, allergens, viruses, and bacteria.
FULL STORY →
The New York Times
A bird-flu pandemic in people? Here’s what it might look like
Scott Hensley of the Perelman School of Medicine says that the bird flu virus would have to change significantly to be able to bind effectively to human cells.
FULL STORY →