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Immunology
Five things to know about this year’s ‘tripledemic’
Five things to know about this year’s ‘tripledemic’
The Perelman School of Medicine’s E. John Wherry and Scott Hensley discuss the season’s confluence of COVID-19, influenza, and RSV and how our bodies are responding.
CAR T cell therapy may eliminate tumor cells missed by surgery
CAR T cell therapy may eliminate tumor cells missed by surgery
The results of a study led by Penn Medicine’s Carl June greenlights preclinical trials for the application of CAR T therapy in gel form to surgical wounds following partial tumor removal to eliminate residual tumor cells.
Advances in cancer research
Advances in cancer research
Recent research shows promise in a novel CAR T therapy after cancer relapse, and a novel treatment for multiple myeloma.
CAR T cell therapy reaches beyond cancer
CAR T cell therapy reaches beyond cancer
Penn Medicine researchers laud the early results for CAR T therapy in lupus patients, which point to broader horizons for the use of personalized cellular therapies.
NIH-funded canine immunotherapy data center charts a path toward transformative therapies
NIH-funded canine immunotherapy data center charts a path toward transformative therapies
With support recently granted for five more years, Nicola Mason of the School of Veterinary Medicine and Qi Long of the Perelman School of Medicine hope their work leads to new insights in cancer care for people as well as pets.
$50M gift to accelerate Colton Center for Autoimmunity at Penn Medicine
$50M gift to accelerate Colton Center for Autoimmunity at Penn Medicine
The center for autoimmune research brings together star faculty, powering the next generation of autoimmune disease advances.
Penn Medicine CAR T therapy expert Carl June receives 2022 Keio Medical Science Prize
Penn Medicine CAR T therapy expert Carl June receives 2022 Keio Medical Science Prize
The award from Japan’s oldest private university honors outstanding contributions to medicine and life sciences.
T cells that ‘nibble’ tumors unwittingly help cancer evade the immune response
T cells that ‘nibble’ tumors unwittingly help cancer evade the immune response
Blocking this process, known as trogocytosis, improved the ability of a CAR T cell therapy to treat cancer in mice, according to research led by School of Veterinary Medicine scientists.
Monkeypox: What is known and unknown
Monkeypox: What is known and unknown
The current outbreak of monkeypox is showing no sign of slowing. Stuart Isaacs of the Perelman School of Medicine, an expert on poxviruses, sheds light on the disease, its prevention and treatment, and what to watch for this fall.
Cancer cells selectively load ‘drones’ to keep T cells from infiltrating tumors
Cancer cells selectively load ‘drones’ to keep T cells from infiltrating tumors
Biologist Wei Guo and colleagues elucidate the process of sorting and loading cargo for these biological drones with implications for a more targeted and effective use of checkpoint inhibitor drugs in cancer treatment.
In the News
Nature
The race to supercharge cancer-fighting T cells
Carl June and Avery Posey of the Perelman School of Medicine discuss the progression and expansion of CAR-T cell therapies.
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MIT Technology Review
What’s next for mRNA vaccines
Norbert Pardi of the Perelman School of Medicine and colleagues are developing a universal mRNA flu vaccine, featuring remarks from mRNA pioneer Katalin Karikó.
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CNN
Researchers make important progress toward a possible universal flu vaccine
Scott Hensley of the Perelman School of Medicine and colleagues are using mRNA technology to develop a universal flu vaccine.
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Bloomberg
Health experts are split on who should get COVID booster shots and when
Stanley Plotkin and Paul Offit of the Perelman School of Medicine share their thoughts on COVID vaccine efficacy and their desire for more concrete booster data.
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Jerusalem Post
TAU establishes center for autoimmune research
The Penn Colton Center for Autoimmunity at the Perelman School of Medicine is noted for its experimental and theoretical studies in immunology.
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NPR
CRISPR gene-editing may boost cancer immunotherapy, new study finds
Carl June of the Perelman School of Medicine says that off-the-shelf CAR-T cell therapies using CRISPR would be a game-changer.
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