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A cold triggered an autoimmune disease in a Pa. man. Now he’s channeling his challenges into advocacy for people with rare diseases

A cold triggered an autoimmune disease in a Pa. man. Now he’s channeling his challenges into advocacy for people with rare diseases

Research led by Jonathan Sussman of the Perelman School of Medicine found that many rare disease patients report high annual spending on medical costs, reduced work and school hours, and difficulty accessing medication or services after diagnosis.

Dogs with cancer are helping save lives—both canine and human
Nicola Mason, Antonia Rotolo, and Mary Beth Boland with Rex, first dog treated on metastatic osteosarcoma trial.

(Left to right) Nicola Mason, Mary Beth Boland, and Antonia Rotolo with Rex, first dog treated on metastatic osteosarcoma trial.

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Dogs with cancer are helping save lives—both canine and human

The Comparative Immunotherapy Program led by Penn Vet’s Nicola Mason is redefining how therapies are developed and tested—uniting human and veterinary medicine to move promising immunotherapies forward.

4 min. read

Reimagined Penn Medicine facility set to usher in a bold new era of Immune Health discovery
Penn President J. Larry Jameson, Kevin Mahoney and two others cutting a Penn Medicine ribbon at a Ribbon Cutting ceremony.

(From left) Kevin B. Mahoney, chief executive officer of the University of Pennsylvania Health System; Penn President J. Larry Jameson; Jonathan A. Epstein, dean of the Perelman School of Medicine (PSOM); and E. Michael Ostap, senior vice dean and chief scientific officer at PSOM, at the ribbon cutting at 3600 Civic Center Boulevard.

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Reimagined Penn Medicine facility set to usher in a bold new era of Immune Health discovery

3600 Civic Center Boulevard will bring together key researchers and technologies in Immune Health, the Colton Center for Autoimmunity, and infectious diseases to drive breakthrough science.

Eric Horvath

2 min. read

2026 Elaine Redding Brinster Prize honors breakthrough in immune system research

2026 Elaine Redding Brinster Prize honors breakthrough in immune system research

The Institute for Regenerative Medicine at Penn has awarded the Elaine Redding Brinster Prize in Science or Medicine to Zhijian ‘James’ Chen, a biochemist at UT Southwestern Medical Center in Dallas, for his discovery of the DNA-sensing enzyme cyclic GMP-AMP synthase (cGas) and its role in immune and inflammatory response.

How discoveries become cures
Two doctors in white lab coats in a lab.

Image: Margo Reed

How discoveries become cures

Public investments in biomedical research have an outsized effect, driving new scientific insights, economic growth, and ultimately treatments and cures.

3 min. read