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Immunology
$50M gift to accelerate Colton Center for Autoimmunity at Penn Medicine
$50M gift to accelerate Colton Center for Autoimmunity at Penn Medicine
The center for autoimmune research brings together star faculty, powering the next generation of autoimmune disease advances.
Penn Medicine CAR T therapy expert Carl June receives 2022 Keio Medical Science Prize
Penn Medicine CAR T therapy expert Carl June receives 2022 Keio Medical Science Prize
The award from Japan’s oldest private university honors outstanding contributions to medicine and life sciences.
T cells that ‘nibble’ tumors unwittingly help cancer evade the immune response
T cells that ‘nibble’ tumors unwittingly help cancer evade the immune response
Blocking this process, known as trogocytosis, improved the ability of a CAR T cell therapy to treat cancer in mice, according to research led by School of Veterinary Medicine scientists.
Monkeypox: What is known and unknown
Monkeypox: What is known and unknown
The current outbreak of monkeypox is showing no sign of slowing. Stuart Isaacs of the Perelman School of Medicine, an expert on poxviruses, sheds light on the disease, its prevention and treatment, and what to watch for this fall.
Cancer cells selectively load ‘drones’ to keep T cells from infiltrating tumors
Cancer cells selectively load ‘drones’ to keep T cells from infiltrating tumors
Biologist Wei Guo and colleagues elucidate the process of sorting and loading cargo for these biological drones with implications for a more targeted and effective use of checkpoint inhibitor drugs in cancer treatment.
Deconstructing the mechanics of bone marrow disease
Deconstructing the mechanics of bone marrow disease
A new understanding of how mechanical features of bone marrow affect resident immune cells in a fibrotic cancer points to future therapeutic strategies for cancers and fibrotic diseases.
One protein’s role in genomic intermingling and T cell development
One protein’s role in genomic intermingling and T cell development
The findings, from a team led by Golnaz Vahedi of Penn Medicine, could have implications for T-cell based immunotherapies for cancer and other conditions.
Regulating the regulators of the immune system
Regulating the regulators of the immune system
Research led by School of Veterinary Medicine scientists reveals a new layer of complexity with which the immune system finds a balance between controlling pathogens and protecting healthy tissue.
CAR T cells suppress GI solid tumor cells without toxicity to healthy tissue
CAR T cells suppress GI solid tumor cells without toxicity to healthy tissue
New research finds that CAR T cells can eliminate solid tumors, but do not damage healthy, normal tissues that also express a tumor antigen, because the tumor antigen is sequestered and hidden between the normal cells.
Decade-long remission after CAR T cell therapy
Decade-long remission after CAR T cell therapy
Two patients represent longest-known CAR T cell response to date, providing insight into treatment effect and outcomes.
In the News
Forbes
$50 million gift to University of Pennsylvania for autoimmune disease research
A $50 million gift from Wharton School alumni Judy and Stewart Colton will further develop the work of the Colton Center for Autoimmunity at the Perelman School of Medicine, with a statement from President Liz Magill.
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Philadelphia Inquirer
$50 million gift to Penn is aimed at new treatments for autoimmune disease
E. John Wherry of the Perelman School of Medicine hopes to find better answers for autoimmune conditions as director of the Colton Center for Autoimmunity, established and now accelerated by alumni Judy and Stewart Colton.
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The New York Times
Scientists have made a human microbiome from scratch
Gary Wu of the Perelman School of Medicine comments on the importance of the new creation of a synthetic human microbiome.
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The New York Times
The many uses of CRISPR: Scientists tell all
Carl June and Ed Stadtmauer comment on the last decade’s revolution in the treatment of diseases.
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Chemistry World
A decade of CAR T cell therapy
In a feature on the history and future of CAR T, the work of Carl June, Michael C. Milone, Aimee Payne, Drew Weissman, and Jonathan Epstein from the Perelman School of Medicine is highlighted.
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Technology Networks
CAR T cells engineered to deliver RNA to enhance immunotherapy response
Andy J. Minn of the Perelman School of Medicine explains how Chimeric antigen receptor T cells typically are like lone soldiers without backup.
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