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Immunology
Scratching beneath the surface of itchy skin
Scratching beneath the surface of itchy skin
Researchers from Penn Vet provide insights into how a species of worms found a way around the mammalian urge to scratch an itch.
An integral T cell pathway helps regulate female gene expression
An integral T cell pathway helps regulate female gene expression
Penn Vet researchers have revealed a connection between NF-κB signaling pathways and X chromosome inactivation, which has implications for understanding sex-based immune responses during infection.
Combo immunotherapy produces distinct waves of cancer-fighting T cells
Combo immunotherapy produces distinct waves of cancer-fighting T cells
Researchers from Penn’s Abramson Cancer Center have found that a novel tool that tracks immune health over time has revealed new insights on immune cell activation.
A newly identified immune checkpoint protein may lead to future cancer therapies
A newly identified immune checkpoint protein may lead to future cancer therapies
Penn Medicine researchers have found that knocking out a T cell’s CD5 gene greatly enhances the cell’s anticancer activity in a variety of preclinical cancer models.
New ‘armored’ CAR therapy produces significant responses in cancer patients
New ‘armored’ CAR therapy produces significant responses in cancer patients
For patients whose cancers don't respond to current CAR T cell therapies, a new, modified CAR T cell therapy by Penn’s Carl June shows promise in a phase 1 clinical trial.
Honoring a life scientist’s lifesaving science
Honoring a life scientist’s lifesaving science
Carl June accepted the 2024 Breakthrough Prize in Life Sciences at a Los Angeles ceremony, making him the sixth recipient from Penn.
Study reveals inequities in access to transformative CAR T cell therapy
Study reveals inequities in access to transformative CAR T cell therapy
Penn Medicine researchers have assessed the percentage of patients from minority health populations and reveal inequities in access to transformative CAR T cell therapy.
Accelerating CAR T cell therapy: Lipid nanoparticles speed up manufacturing
Accelerating CAR T cell therapy: Lipid nanoparticles speed up manufacturing
Penn Engineers have developed a novel method for manufacturing CAR T cells using lipid nanoparticles as delivery vehicles.
Initial SARS-CoV-2 vaccinations prime immune cells to respond to subsequent variants
Initial SARS-CoV-2 vaccinations prime immune cells to respond to subsequent variants
Immunological imprinting from the original ancestral SARS-CoV-2 strain has a significant impact on the antibody responses to the variants and boosters based on them.
Mapping pancreatic cancer to improve immunotherapy
Mapping pancreatic cancer to improve immunotherapy
Gregory L. Beatty, an associate professor of hematology-oncology and member of Penn Medicine’s Abramson Cancer Center, and his team focus on improving immunotherapy for pancreatic cancer.
In the News
Time
Scientists are racing to develop a new bird flu vaccine
Drew Weissman and Scott Hensley of the Perelman School of Medicine are testing a vaccine to prevent a strain of H5N1 bird flu in chickens and cattle.
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Fortune
California declares a state of emergency as a new severe bird flu case was discovered. What it means for the rest of the country
Scott Hensley of the Perelman School of Medicine says the latest H5N1 bird flu strain might have a greater potential to adapt and cause severe disease in humans.
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HealthDay
Keto diet supplement could boost a cancer treatment's effectiveness
A study by Perelman School of Medicine student Puneeth Guruprasad and postdoc Shan Liu suggests that a component of the keto diet could boost CAR T cell therapy to help treat cancer.
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Stat
Scientists confront a mystery: Why have U.S. bird flu cases been so mild?
Scott Hensley of the Perelman School of Medicine says that one or two mutations can greatly change the pathogenicity profile of current bird flu viruses.
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The Scientist
A beneficial bacterium helps wounds heal
Research by Ellen White of the Perelman School of Medicine and colleagues in Elizabeth Grice’s lab suggests that a bacterium found in chronic wounds can aid healing.
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ScienceFriday.com
CAR-T cell therapies show promise for autoimmune diseases
Daniel Baker, a Ph.D. student in Carl June’s lab at the Perelman School of Medicine, discusses the results of a study on donor CAR-T cell therapy.
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