Immunology | Penn Today

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Scientists confront a mystery: Why have U.S. bird flu cases been so mild?

Scott Hensley of the Perelman School of Medicine says that one or two mutations can greatly change the pathogenicity profile of current bird flu viruses.

The Scientist

A beneficial bacterium helps wounds heal

Research by Ellen White of the Perelman School of Medicine and colleagues in Elizabeth Grice’s lab suggests that a bacterium found in chronic wounds can aid healing.

ScienceFriday.com

CAR-T cell therapies show promise for autoimmune diseases

Daniel Baker, a Ph.D. student in Carl June’s lab at the Perelman School of Medicine, discusses the results of a study on donor CAR-T cell therapy.

Person scratching an itch on their right arm.

Scratching beneath the surface of itchy skin

Researchers from Penn Vet provide insights into how a species of worms found a way around the mammalian urge to scratch an itch.

An integral T cell pathway helps regulate female gene expression

Penn Vet researchers have revealed a connection between NF-κB signaling pathways and X chromosome inactivation, which has implications for understanding sex-based immune responses during infection.

Live Science

‘Any protein you can imagine, it can deliver’: AI will help discover the next breakthrough in RNA, says Nobel Prize winner Dr. Drew Weissman

Drew Weissman of the Perelman School of Medicine is launching a new RNA research hub that will use artificial intelligence to help train scientists and guide their experiments.

Nature

Is bird flu spreading among people? Data gaps leave researchers in the dark

Scott Hensley of the Perelman School of Medicine says that there are fears of bird flu spreading at low levels through humans in a Missouri community.

Combo immunotherapy produces distinct waves of cancer-fighting T cells

Researchers from Penn’s Abramson Cancer Center have found that a novel tool that tracks immune health over time has revealed new insights on immune cell activation.

Forbes

Carl June: 2024 will be seen as a breakthrough year for brain cancer

Carl June of the Perelman School of Medicine shares five insights on using CAR T cell therapy to combat cancer, featuring remarks from Bruce Levine.

A newly identified immune checkpoint protein may lead to future cancer therapies

Penn Medicine researchers have found that knocking out a T cell’s CD5 gene greatly enhances the cell’s anticancer activity in a variety of preclinical cancer models.

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