1.21
Immunotherapy
Charting a path forward with unifying definition of cytokine storm
Charting a path forward with unifying definition of cytokine storm
Penn Medicine researchers have developed a unifying definition of “cytokine storm” to provide a framework to assess and treat patients whose immune systems have gone rogue.
Novel Dual CAR T cell immunotherapy promising for targeting the HIV reservoir
Novel Dual CAR T cell immunotherapy promising for targeting the HIV reservoir
A new alteration to the way T cells are engineered has significant implications for using engineered T cells to fight both HIV and cancer.
A potential cause of CAR T side effects, and a path forward
A potential cause of CAR T side effects, and a path forward
Single cell sequencing aided researchers in identifying a previously undiscovered molecule in the brain.
Avery Posey’s cancer research takes high risks for big rewards
Avery Posey’s cancer research takes high risks for big rewards
The assistant professor of systems pharmacology and translational therapeutics, who studied with Carl June as a postdoctoral fellow, combines his two research passions—gene therapy and investigating ‘little known’ biology—in the pursuit of new knowledge.
Navigating cytokine storms
Navigating cytokine storms
Pairing their expertise, Nilam Mangalmurti of the Perelman School of Medicine and Christopher Hunter of the School of Veterinary Medicine have been working to understand the protective and harmful aspects of the immune response, including in COVID-19.
Kathleen Hall Jamieson, Carl June elected to National Academy of Sciences
Kathleen Hall Jamieson, Carl June elected to National Academy of Sciences
The researchers, from the Annenberg Public Policy Center and the Perelman School of Medicine, join a class of honored scholars recognized for their unique and ongoing contributions to original research.
Tailoring treatment for triple-negative breast cancer
Tailoring treatment for triple-negative breast cancer
Research led by the School of Veterinary Medicine’s Rumela Chakrabarti identified a molecular pathway responsible for the disease’s progression and spread.
Racing to deliver a vaccine to the masses
Racing to deliver a vaccine to the masses
While the world works to flatten the curve, scientists at Penn and Wistar hope to deliver the COVID-19 pandemic’s silver bullet: a vaccine that effectively protects people from infection.
Alternative immune cells may surpass T cells to fight solid tumors
Alternative immune cells may surpass T cells to fight solid tumors
Penn researchers have shown success using genetically engineered macrophages, an immune cell that eats invaders in the body, to target solid tumors.
A new way to predict lung cancer treatment response: The blood test
A new way to predict lung cancer treatment response: The blood test
A Penn study shows a better clinical response to immunotherapy correlates with higher ratio of tumor mutations detected by a liquid biopsy.
In the News
The New York Times
A woman may have been cured of HIV without medical treatment
Una O’Doherty of the Perelman School of Medicine commented on a study that appeared to fully suppress HIV without using drugs. “It’s certainly encouraging but speculative,” she said. “I need to see more before I would say, ‘Oh, she’s cured.’”
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The New York Times
Decades-old Soviet studies hint at coronavirus strategy
Paul Offit of the Perelman School of Medicine said the benefits of a repurposed vaccines are limited. “We are much better off with a vaccine that induces specific immunity,” he said.
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