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Immunotherapy
Navigating cytokine storms
Navigating cytokine storms
Pairing their expertise, Nilam Mangalmurti of the Perelman School of Medicine and Christopher Hunter of the School of Veterinary Medicine have been working to understand the protective and harmful aspects of the immune response, including in COVID-19.
Kathleen Hall Jamieson, Carl June elected to National Academy of Sciences
Kathleen Hall Jamieson, Carl June elected to National Academy of Sciences
The researchers, from the Annenberg Public Policy Center and the Perelman School of Medicine, join a class of honored scholars recognized for their unique and ongoing contributions to original research.
Tailoring treatment for triple-negative breast cancer
Tailoring treatment for triple-negative breast cancer
Research led by the School of Veterinary Medicine’s Rumela Chakrabarti identified a molecular pathway responsible for the disease’s progression and spread.
Racing to deliver a vaccine to the masses
Racing to deliver a vaccine to the masses
While the world works to flatten the curve, scientists at Penn and Wistar hope to deliver the COVID-19 pandemic’s silver bullet: a vaccine that effectively protects people from infection.
Alternative immune cells may surpass T cells to fight solid tumors
Alternative immune cells may surpass T cells to fight solid tumors
Penn researchers have shown success using genetically engineered macrophages, an immune cell that eats invaders in the body, to target solid tumors.
A new way to predict lung cancer treatment response: The blood test
A new way to predict lung cancer treatment response: The blood test
A Penn study shows a better clinical response to immunotherapy correlates with higher ratio of tumor mutations detected by a liquid biopsy.
CRISPR-edited immune cells can survive and thrive after infusion into cancer patients
CRISPR-edited immune cells can survive and thrive after infusion into cancer patients
In the first U.S. clinical trial, cells removed from patients and brought back into the lab were able to kill cancer months after their original manufacturing and infusion.
Defect driving resistance to CAR T therapy identified
Defect driving resistance to CAR T therapy identified
A new study identifies the mechanism that prevents cell death, and can guide future immunotherapy strategies in patients whose blood cancers are resistant to CAR T therapy.
Penn nanoparticles are less toxic to T cells engineered for cancer immunotherapy
Penn nanoparticles are less toxic to T cells engineered for cancer immunotherapy
By using messenger RNA across the T cell’s membrane via a nanoparticle instead of a DNA-rewriting virus on extracted T cells, CAR T treatments could have fewer side effects.
These overlooked global diseases take a turn under the microscope
These overlooked global diseases take a turn under the microscope
Faculty at the School of Veterinary Medicine target neglected tropical diseases with advanced science, cross-disciplinary collaborations, and work in the lab and the field.
In the News
The New York Times
Decades-old Soviet studies hint at coronavirus strategy
Paul Offit of the Perelman School of Medicine said the benefits of a repurposed vaccines are limited. “We are much better off with a vaccine that induces specific immunity,” he said.
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