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A hard reset on electroconvulsive therapy
Medical brain scans on  multiple computer screens.

Image: gorodenkoff via Getty Images

A hard reset on electroconvulsive therapy

New research from Penn Medicine finds that ECT sets in motion a brain event that resets its neurons, and has the potential to guide personalized ECT dosing to target specific outcomes in the brain.

From Penn Medicine News

2 min. read

Delivering a one-two punch to superbugs to fight infections
Rakesh Krishnan sits at a computer staring at a 3D rendering of a protein.

Researchers led by César de la Fuente of the Perelman School of Medicine have created new peptides that fight hard-to-treat “superbug” infections by punching holes in bacterial cells and stimulating immune cells to signal for more defenders.

(Image: Courtesy of Jianing Bai) 

Delivering a one-two punch to superbugs to fight infections

Penn researchers create mirror-image molecules that both kill pathogens outright and rally the immune system—an advance aimed at the growing crisis of antimicrobial resistance.

3 min. read

New tools to treat retinal degenerations at advanced stages of disease
Raghavi Sudharsan and William Beltran by a microscope in a lab.

Raghavi Sudharsan and William Beltran of the Division of Experimental Retinal Therapies at Penn’s School of Veterinary Medicine.

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New tools to treat retinal degenerations at advanced stages of disease

A collaborative team of researchers led by vision scientists at the School of Veterinary Medicine have developed novel promoters that drive strong and specific gene expression in rod and cone photoreceptors in mid-to-late stages of disease, potentially offering new and improved options for gene therapy.

3 min. read

Cost-effective, lifesaving weather predictions
Satellite image of Hurricane Helene, 2006

Image: Courtesy of NASA’s Jesse Allen, Earth Observatory

Cost-effective, lifesaving weather predictions

Penn professor Paris Perdikaris and collaborators developed Aurora, a machine-learning model that has predictive capabilities for air quality, ocean waves, tropical cyclone tracks, and weather.

5 min. read

Lillian Miller: May grad turned Penn Ph.D.
Lillian Miller and Irina Marinov

Lillian Miller (left) graduated as a chemistry and environmental scieces double major in May. This summer, she returns to begin her graduate training in Irina Marinov’s (right), where researchers use big data and computational techniques to make better climate models.

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Lillian Miller: May grad turned Penn Ph.D.

Lillian Miller, a May graduate from the College, will begin graduate studies in the laboratory of Irina Marinov this summer, where she is leveraging big data to tackle ocean and climate-focused research.

5 min. read

AI x Science Postdoctoral Fellowship
Aerial shot of Amy Guttman Hall

Bhuvnesh Jain of the School of Arts & Sciences has teamed up with PIK University Professor René Vidal of the Perelman School of Medicine and the School of Engineering and Applied Science to create the AI x Science Fellowship offering postdoctoral researchers across the University opportunities to collaborate across disciplines.

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AI x Science Postdoctoral Fellowship

Bhuvnesh Jain and René Vidal have teamed up to create the AI x Science Fellowship, which builds on the thriving postdoctoral program of the Data Driven Discovery Initiative to foster cross-disciplinary collaboration among researchers across the University.

6 min. read

Livesaving personalized CRISPR editing therapy
Kiran Musunuru and Rebecca Ahrens-Nicklas holding KJ in the hospital.

Penn Medicine’s Kiran Musunuru and Rebecca Ahrens-Nicklas holding KJ post infusion.

(Image: Courtesy of Children’s Hospital of Philadelphia)

Livesaving personalized CRISPR editing therapy

A landmark study from CHOP and Penn Medicine showcases the power of customized gene editing therapy to treat a patient with a rare metabolic disease

Matt Toal

5 min. read