Research | Penn Today

Microscopic view of a glioblastoma organoid.

Brain tumor organoids accurately model patient response to CAR T cell therapy

Lab-grown tumors respond to cell therapy the same as tumors in the patients’ brains, according to researchers at Penn Medicine.

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A lipid nanoparticle delivers an mRNA cure for preeclampsia

Doctoral student Kelsey Swingle developed a lipid nanoparticle that delivers an mRNA therapeutic that reduces maternal blood pressure through the end of gestation and improves fetal health and blood circulation in the placenta.

Trust in court system at record low: Gallup

An October survey from the Annenberg Public Policy Center found that the public’s trust in the U.S. Supreme Court has dropped to a record low.

Family offices face hidden risks in making direct investments

According to a study by Raphael “Raffi” Amit of the Wharton School and colleagues, direct investments in private companies could mean taking on more risk than expected if family offices aren’t leveraging their resources.

For kids with rare genetic disorders, customized CRISPR treatments offer hope

Scientists at Penn are trying to develop a template for groups of rare conditions that are similar enough to be affected by a single, easily adaptable gene-editing treatment.

In mouse studies, new hope against a dangerous complication of pregnancy

Doctoral student Kelsey Swingle in the School of Engineering and Applied Science and colleagues are using mRNA molecules to treat pre-eclampsia, a common pregnancy complication.

Payroll deduction savings programs improve retirement security: State auto IRAs are vital to expanding coverage

New AARP research based on a methodology published by the Wharton School finds that about half of American working adults lack access to a payroll-deduction workplace retirement savings plan, making it much more difficult to save for retirement.

3-D rendering of chimeric antigen receptor T (CAR-T) cell therapy, a treatment for a variety of cancers

Keto diet metabolite may power up CAR T cells to kill cancer

Laboratory studies reveal a potentially low-tech intervention to improve personalized cell therapy.

What a new innovation index tells us about Philadelphia

Penn is lauded for its research and development efforts, including the modified mRNA technique that was commercialized into a COVID vaccine and won its researchers a Nobel Prize last year.

Bright spots represent individual catalyst molecules captured under cryogenic conditions to prevent clustering.

Mapping molecular arrangements to pave the way for better catalytic systems

The Stach Group in Penn Engineering led a collaborative team identifying how chemical catalysts drive the creation of liquid fuels from sunlight, paving the way for more efficient removal of greenhouse gases from the atmosphere.

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