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Targeting tumor supporting cells: Advancing CAR T success in pancreatic cancer
Pancreatic cancer cells.

Image: Nemes Laszlo/Science Photo Library via Getty Images

Targeting tumor supporting cells: Advancing CAR T success in pancreatic cancer

Research led by Penn Vet’s Ellen Puré has used lipid nanoparticles to generate CAR T cells directed at a type of tumor support cells—cancer-associated fibroblasts—melting away the protective barrier around pancreatic tumor cells and paving the way for a potentially safer, more accessible, and cost-effective method to treat solid tumors.

3 min. read

A stiff defense: Rethinking gum disease
A section of healthy human gum tissue captured using an imaging technique called Second Harmonic Generation microscopy. In this sample, collagen fibers (shown in yellow), which give healthy gums their firm, resilient stiffness, are dense and well-organized—acting as a supportive scaffold for the surrounding cells (shown in teal).

A section of healthy human gum tissue captured using an imaging technique called Second Harmonic Generation microscopy. In this sample, collagen fibers (shown in yellow), which give healthy gums their firm, resilient stiffness, are dense and well-organized—acting as a supportive scaffold for the surrounding cells (shown in teal).

(Image: Hardik Makkar)

A stiff defense: Rethinking gum disease

Penn Dental Medicine’s Kyle H. Vining and Hardik Makkar take a biomaterials approach to understanding periodontal disease, using a hydrogel system to investigate how the physical properties of the gum tissue impact inflammation.

3 min. read

Analyzing the news with AI
A person standing inside multicoloured data sheets and social media chat icons organised into circular pattern.

Image: Andriy Onufriyenko via Getty Images

Analyzing the news with AI

Annenberg School for Communication postdoctoral fellow Baird Howland looks at prominent narratives in the news media and how they shape Americans’ worldviews.

Hailey Reissman

When bone behaves like a sponge
Three members of the Tertuliano lab looking at a computer in the lab.

To visualize the nanoscale structures, the Tertuliano lab often uses large-scale models like the one pictured.

(Image: Sylvia Zhang)

When bone behaves like a sponge

Penn Engineers in the Tertuliano Lab have developed a nanoengineered 3D-printed scaffold for observing how cells feel force.

Melissa Pappas

2 min. read

Mapping the expanding cosmos: Dark Energy Survey unveils clearest picture yet
Terrestrial telescope in Chile under a starlit sky.

The Dark Energy Survey used a 570-megapixel camera mounted on the 4-metre Victor M. Blanco Telescope in Chile to image 5,000 square degrees of southern sky. The survey discovered more than 1,000 supernovae and mapped millions of galaxies to help astronomers better understand the accelerating expansion of our universe.

(Image: Courtesy of Dark Energy Survey Collaborative)

Mapping the expanding cosmos: Dark Energy Survey unveils clearest picture yet

The Dark Energy Survey collaborative, including Penn researchers, recently released an analysis that gives the clearest picture yet of how dark energy is driving the universe’s expansion and how matter—including galaxies and groups of galaxies—has been organized over cosmic time.

3 min. read

How markets can help society adapt to climate change
People working on a laptop and a screen looking at climate initiatives.

Image: Kindamorphic via Getty Images

How markets can help society adapt to climate change

Environmental and labor economist R. Jisung Park co-authored a new paper reporting that carefully designed markets and supportive public policy can help individuals and communities more effectively approach climate adaptation.

From the School of Social Policy & Practice

2 min. read

Engineers sharpen gene-editing tools to target cystic fibrosis
Engineering researchers at a whiteboard in the Gao lab.

Beyond cystic fibrosis, the refined base editor could help researchers tackle a wide range of genetic diseases caused by single-letter DNA changes.

(Image: Bella Ciervo)

Engineers sharpen gene-editing tools to target cystic fibrosis

Researchers at Penn Engineering have developed a modified base-pair editor that offers improved accuracy and could help treat diseases like cystic fibrosis.

Ian Scheffler

2 min. read

Who, What, Why: Katelyn Candido on improving surgical procedures and keeping health care human-first
Katelyn Candido sitting on a staircase, smiling and facing forward, wearing a white coat and blue scrubs in the Perelman School of Medicine

Katelyn Candido, a second-year medical student at PSOM and aspiring neurosurgeon, researches a novel tool’s utility for improving surgical precision.

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  • Who, What, Why

    • Who, What, Why: Katelyn Candido on improving surgical procedures and keeping health care human-first

    Second-year medical student Katelyn Candido shares insight into her research project on a promising tool for improving surgical precision and efficiency, and why she aims to drive equitable patient care through a career in neurosurgery.

    3 min. read

    David Meaney on Penn’s research enterprise
    David Meaney leaning against a door in Penn's College Hall.

    David Meaney, Penn’s vice provost for research.

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  • Q&A

    • David Meaney on Penn’s research enterprise

    Penn Today spoke with David Meaney, vice provost for research, about research at Penn—its current focus and plans for its growth and evolution in the continued quest to help make lives better.

    4 min. read