Engineering CAR T cells to activate a bodily response to solid tumors
A new Penn study shows that CAR T cells expressing RN7SL1, a naturally occurring RNA, can activate the body’s natural immune cells against difficult-to-treat cancers.
Smart dental implants
Geelsu Hwang of the School of Dental Medicine and colleagues are developing a smart dental implant that resists bacterial growth and generates its own electricity through chewing and brushing to power a tissue-rejuvenating light.
2022 Breakthrough Prize in Life Sciences awarded to mRNA pioneers Drew Weissman and Katalin Karikó
Weissman and Karikó are honored for engineering modified RNA technology which enabled rapid development of effective COVID-19 vaccines.
Versatile ‘chemoproteomic probes’ for activity-based protein profiling
A new study uses organohydrazine probes to map chemical reactivty across the proteome, allowing for a diverse classes of proteins and biological pathways to be studied.
Interact, adapt, repeat: A summer studying coevolution
Sophomores Linda Wu and Nova Meng spent the summer studying coevolution among plants, mutualistic bacteria, and parasitic nematodes in Corlett Wood’s biology lab.
COVID-19 mRNA vaccine that uses fundamental Penn technology receives FDA approval
Pfizer/BioNTech’s vaccine to prevent COVID-19 uses fundamental modified mRNA technology created by Drew Weissman and Katalin Karikó at the Perelman School of Medicine.
Evolutionary ‘arms race’ may help keep cell division honest
Research from the lab of Michael Lampson in the School of Arts & Sciences suggests that certain proteins may have evolved to reduce the likelihood of chromosomes “cheating” to bias their chance of winding up in an egg during the cell-division process meiosis.
How schools of ‘microswimmers’ can increase their cargo capacity
Penn researchers describe how groups of microscopic, self-propelled droplets can transport more material through narrow channels using a process called collective hydrodynamic entrainment.
Artist and professor David Hartt is ‘of the moment’
This year alone four museums and two galleries are featuring work by artist David Hartt of the Stuart Weitzman School of Design, including currently at the Philadelphia Museum of Art.
Patient preferences do not explain racial disparities in opioid prescribing
Black patients are less likely to get opioids for acute pain.
In the News
Penn scientists win $3 million Breakthrough Prize for RNA research that enabled COVID-19 vaccines
Katalin Karikó and Drew Weissman of the Perelman School of Medicine have been awarded a $3 million Breakthrough Prize for research that paved the way for COVID-19 vaccines. “It’s been very wonderful,” said Weissman. “I never thought it was possible.”
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These obese mice lost weight by ‘sweating’ their fat, Penn team finds
Taku Kambayashi and med student Ruth Chao of the Perelman School of Medicine found that they could stimulate fat loss in obese mice by treating the animals with a type of cytokine.
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