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Engineers sharpen gene-editing tools to target cystic fibrosis
Engineering researchers at a whiteboard in the Gao lab.

Beyond cystic fibrosis, the refined base editor could help researchers tackle a wide range of genetic diseases caused by single-letter DNA changes.

(Image: Bella Ciervo)

Engineers sharpen gene-editing tools to target cystic fibrosis

Researchers at Penn Engineering have developed a modified base-pair editor that offers improved accuracy and could help treat diseases like cystic fibrosis.

Ian Scheffler

2 min. read

Who, What, Why: Katelyn Candido on improving surgical procedures and keeping health care human-first
Katelyn Candido standing next to a wall, smiling and facing forward with arms crossed, wearing a white coat and blue scrubs in the Perelman School of Medicine

Katelyn Candido, a second-year medical student at PSOM and aspiring neurosurgeon, researches a novel tool’s utility for improving surgical precision. Informed by experiences as a first-generation Hispanic student, Candido also deeply values the human-centered side of medicine, helping drive equitable care in Philadelphia and beyond.

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Who, What, Why: Katelyn Candido on improving surgical procedures and keeping health care human-first

Second-year medical student Katelyn Candido shares insight into her research project on a promising tool for improving surgical precision and efficiency, and why she aims to drive equitable patient care through a career in neurosurgery.
David Meaney on Penn’s research enterprise
David Meaney leaning against a door in Penn's College Hall.

David Meaney, Penn’s vice provost for research.

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  • Q&A

    • David Meaney on Penn’s research enterprise

    Penn Today spoke with David Meaney, vice provost for research, about research at Penn—its current focus and plans for its growth and evolution in the continued quest to help make lives better.

    4 min. read

    Novel plant-based approach to a better, cheaper GLP-1 delivery system
    Three researchers in a greenhouse full of lettuce heads.

    Researchers, including Rahul Singh (left), in the Daniell lab’s greenhouse where the production of clinical grade transgenic lettuce occurs.

    (Image: Henry Daniell)

    Novel plant-based approach to a better, cheaper GLP-1 delivery system

    Research led by Penn Dental’s Henry Daniell investigates the use of a lettuce-based, plant-encapsulated delivery platform as a new oral delivery of two GLP-1 drugs previously approved by the FDA in injectable form.

    3 min. read

    How confidence changes consumer loyalty

    How confidence changes consumer loyalty

    New research from Wharton marketing professor Jonah Berger explores how experience in a category shapes how confident consumers feel, which has important consequences for brands.

    Exploring Black America: A historian’s unique path of inquiry
    Marcia Chatelain

    Marcia Chatelain’s next book, coming out this fall, is a narrative history of the women who played roles in the 1963 March on Washington.

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    Exploring Black America: A historian’s unique path of inquiry

    Pulitzer Prize-winning author Marcia Chatelain, a Penn Presidential Compact Professor of Africana Studies, takes a unique approach to history, from the impact of fast food to the leadership of the Civil Rights Movement.

    4 min. read

    Anthropomorphizing AI

    Anthropomorphizing AI

    Artificial intelligence doesn’t make decisions like a human, but according to research from Arts & Sciences economics professor Kevin He, people seem to think it does.

    From Omnia

    2 min. read

    How ancient attraction shaped the human genome
    Human X chromosomes, karyotype, structure, division in genetic biological study

    Why do modern humans carry small amounts of Neanderthal DNA almost everywhere in their genome except on the X chromosome? A new study by Alexander Platt and Daniel Harris in the lab of geneticist Sarah Tishkoff suggests the answer lies in ancient attraction. (Pictured) An illustration of a normal karyotype, the full complement of chromosomes arranged in homologous pairs.

    (Image: quantic69 via Getty Images)

    How ancient attraction shaped the human genome

    Research led by geneticist Sarah Tishkoff’s finds that prehistoric mating preferences is a likely explanation for why modern humans have small amounts of Neanderthal genetic elements on their X chromosomes, challenging the idea that human evolution was driven solely by survival of the fittest.

    3 min. read

    Understanding GLP-1 signaling: A path to better therapies
    A person holding their stomach.

    Image: seb_ra via Getty Images

    Understanding GLP-1 signaling: A path to better therapies

    A collaborative study led by an interdisciplinary team of researchers from Penn’s School of Nursing and Perelman School of Medicine found that a novel GLP-1 drug shows promise for reducing nausea and vomiting while maintaining blood sugar.

    2 min. read